Mean platelet volume is decreased in adults with active lupus disease
Background: Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adul...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/27794/7/27794.pdf |
| _version_ | 1824420825307021312 |
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| author | Delgado García, Guillermo Rubén Galarza Delgado, Dionicio Ángel Colunga Pedraza, Iris Jazmín Borjas Almaguer, Omar David Mandujano Cruz, Ilse Benavides Salgado, Daniel Eduardo Martínez Granados, Rolando Jacob Atilano Díaz, Alexandro |
| author_facet | Delgado García, Guillermo Rubén Galarza Delgado, Dionicio Ángel Colunga Pedraza, Iris Jazmín Borjas Almaguer, Omar David Mandujano Cruz, Ilse Benavides Salgado, Daniel Eduardo Martínez Granados, Rolando Jacob Atilano Díaz, Alexandro |
| author_sort | Delgado García, Guillermo Rubén |
| collection | Repositorio Institucional |
| description | Background: Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE.
Objective: We investigated the association between MPV and disease activity in adult patients with SLE.
Methods: In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched.
Results: MPV was significantly decreased with respect to those of inactive patients (7.16 ± 1.39 vs. 8.16 ± 1.50, p = 0.005). At a cutoff level of 8.32 fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r = 0.407, p = 0.001), which in turn is inversely associated with disease activity.
Conclusions: In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker. |
| format | Article |
| id | eprints-27794 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | eprints-277942024-07-30T17:35:37Z http://eprints.uanl.mx/27794/ Mean platelet volume is decreased in adults with active lupus disease Delgado García, Guillermo Rubén Galarza Delgado, Dionicio Ángel Colunga Pedraza, Iris Jazmín Borjas Almaguer, Omar David Mandujano Cruz, Ilse Benavides Salgado, Daniel Eduardo Martínez Granados, Rolando Jacob Atilano Díaz, Alexandro RC Medicina Interna, Psiquiatría, Neurología Background: Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE. Objective: We investigated the association between MPV and disease activity in adult patients with SLE. Methods: In this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched. Results: MPV was significantly decreased with respect to those of inactive patients (7.16 ± 1.39 vs. 8.16 ± 1.50, p = 0.005). At a cutoff level of 8.32 fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r = 0.407, p = 0.001), which in turn is inversely associated with disease activity. Conclusions: In summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker. Elsevier 2016-11 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/27794/7/27794.pdf http://eprints.uanl.mx/27794/7.haspreviewThumbnailVersion/27794.pdf Delgado García, Guillermo Rubén y Galarza Delgado, Dionicio Ángel y Colunga Pedraza, Iris Jazmín y Borjas Almaguer, Omar David y Mandujano Cruz, Ilse y Benavides Salgado, Daniel Eduardo y Martínez Granados, Rolando Jacob y Atilano Díaz, Alexandro (2016) Mean platelet volume is decreased in adults with active lupus disease. Revista Brasileira de Reumatologia, 56 (6). pp. 504-508. ISSN 22555021 https://www.sciencedirect.com/science/article/pii/S2255502116000389?via%3Dihub doi:10.1016/j.rbre.2016.03.003 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Delgado García, Guillermo Rubén Galarza Delgado, Dionicio Ángel Colunga Pedraza, Iris Jazmín Borjas Almaguer, Omar David Mandujano Cruz, Ilse Benavides Salgado, Daniel Eduardo Martínez Granados, Rolando Jacob Atilano Díaz, Alexandro Mean platelet volume is decreased in adults with active lupus disease |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Mean platelet volume is decreased in adults with active lupus disease |
| title_full | Mean platelet volume is decreased in adults with active lupus disease |
| title_fullStr | Mean platelet volume is decreased in adults with active lupus disease |
| title_full_unstemmed | Mean platelet volume is decreased in adults with active lupus disease |
| title_short | Mean platelet volume is decreased in adults with active lupus disease |
| title_sort | mean platelet volume is decreased in adults with active lupus disease |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/27794/7/27794.pdf |
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