Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey
Introduction: Intrathecal chemotherapy is a mainstay component of acute lymphoblastic leukemia treatment. In Mexico, there is a considerable practice variability in aspects, such as the manner of preparation and the administration technique. Objective: Our objective was to describe the different t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Inc.
2021
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| Online Access: | http://eprints.uanl.mx/27710/1/27710.pdf |
| _version_ | 1824420799205867520 |
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| author | Colunga Pedraza, Julia Esther Colunga Pedraza, Perla Rocío Benavides López, Hilda Valeria Mares Gil, José Eduardo Jiménez Antolínez, Yajaira Valentine Mancías Guerra, Consuelo Velasco Ruiz, Ileana Yazmín González Llano, Óscar |
| author_facet | Colunga Pedraza, Julia Esther Colunga Pedraza, Perla Rocío Benavides López, Hilda Valeria Mares Gil, José Eduardo Jiménez Antolínez, Yajaira Valentine Mancías Guerra, Consuelo Velasco Ruiz, Ileana Yazmín González Llano, Óscar |
| author_sort | Colunga Pedraza, Julia Esther |
| collection | Repositorio Institucional |
| description | Introduction: Intrathecal chemotherapy is a mainstay component of acute lymphoblastic leukemia treatment. In Mexico, there is a considerable practice variability in aspects, such as the manner of preparation and the administration technique.
Objective: Our objective was to describe the different techniques used for the application of ITC and review the existing recommendations in the literature.
Method: A cross-sectional, nationwide survey study was conducted by an electronic questionnaire sent to hematologists and oncologists in Mexico. We collected demographic data, personal experience, intrathecal chemotherapy techniques, drug preparation and postprocedural conduct.
Results: We received 173 responses. Twenty percent had an anesthesiologist administering sedation and pain management. The platelet count considered safe was 50 £ 109 /L in 48% of the participants. In 77% (n = 133) of the cases, the conventional needle with stylet used was, 49% did not receive any added diluent in the intrathecal chemotherapy and only 42% were recommended to rest in a horizontal position for more than 30 min.
Conclusion: We identified a considerable variation in the administration of intrathecal chemotherapy across the hematologists in Mexico. We
discuss the implications and opportunities in reducing the variation in our setting, highlighting the unmet need to establish guidelines that should be evaluated by the Mexican professional society to produce a position paper regarding practice standardization. |
| format | Article |
| id | eprints-27710 |
| institution | UANL |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier Inc. |
| record_format | eprints |
| spelling | eprints-277102024-07-23T21:39:38Z http://eprints.uanl.mx/27710/ Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey Colunga Pedraza, Julia Esther Colunga Pedraza, Perla Rocío Benavides López, Hilda Valeria Mares Gil, José Eduardo Jiménez Antolínez, Yajaira Valentine Mancías Guerra, Consuelo Velasco Ruiz, Ileana Yazmín González Llano, Óscar RC Medicina Interna, Psiquiatría, Neurología Introduction: Intrathecal chemotherapy is a mainstay component of acute lymphoblastic leukemia treatment. In Mexico, there is a considerable practice variability in aspects, such as the manner of preparation and the administration technique. Objective: Our objective was to describe the different techniques used for the application of ITC and review the existing recommendations in the literature. Method: A cross-sectional, nationwide survey study was conducted by an electronic questionnaire sent to hematologists and oncologists in Mexico. We collected demographic data, personal experience, intrathecal chemotherapy techniques, drug preparation and postprocedural conduct. Results: We received 173 responses. Twenty percent had an anesthesiologist administering sedation and pain management. The platelet count considered safe was 50 £ 109 /L in 48% of the participants. In 77% (n = 133) of the cases, the conventional needle with stylet used was, 49% did not receive any added diluent in the intrathecal chemotherapy and only 42% were recommended to rest in a horizontal position for more than 30 min. Conclusion: We identified a considerable variation in the administration of intrathecal chemotherapy across the hematologists in Mexico. We discuss the implications and opportunities in reducing the variation in our setting, highlighting the unmet need to establish guidelines that should be evaluated by the Mexican professional society to produce a position paper regarding practice standardization. Elsevier Inc. 2021-12-22 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/27710/1/27710.pdf http://eprints.uanl.mx/27710/1.haspreviewThumbnailVersion/27710.pdf Colunga Pedraza, Julia Esther y Colunga Pedraza, Perla Rocío y Benavides López, Hilda Valeria y Mares Gil, José Eduardo y Jiménez Antolínez, Yajaira Valentine y Mancías Guerra, Consuelo y Velasco Ruiz, Ileana Yazmín y González Llano, Óscar (2021) Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey. Hematology, Transfusion and Cell Therapy, 45 (2). S25-S29. ISSN 2531-1379 https://www.sciencedirect.com/science/article/pii/S2531137921013365?via%3Dihub doi:10.1016/j.htct.2021.09.018 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Colunga Pedraza, Julia Esther Colunga Pedraza, Perla Rocío Benavides López, Hilda Valeria Mares Gil, José Eduardo Jiménez Antolínez, Yajaira Valentine Mancías Guerra, Consuelo Velasco Ruiz, Ileana Yazmín González Llano, Óscar Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey |
| title_full | Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey |
| title_fullStr | Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey |
| title_full_unstemmed | Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey |
| title_short | Real-world practice of acute leukemia intrathecal chemotherapy administration: a mexican nationwide survey |
| title_sort | real world practice of acute leukemia intrathecal chemotherapy administration a mexican nationwide survey |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/27710/1/27710.pdf |
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