Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents
Abstract: Foeniculum vulgare is used for the treatment of diarrhea in Mexican traditional medicine. Hexane extract showed 94 % inhibition of Giardia duodenalis trophozoites at 300 µg/mL. Therefore, 20 constituents of hexane extract were evaluated to determine their antigiardial activity. Interestin...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
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Multidisciplinary Digital Publishing Institute
2022
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/27186/7/27186.pdf.crdownload |
| _version_ | 1824420678424592384 |
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| author | Domínguez Vigil, Irma Guadalupe Mata Cárdenas, Benito David Esquivel Ferriño, Patricia Cristina Avalos Alanís, Francisco Guadalupe Vargas Villarreal, Javier Camacho Corona, María del Rayo |
| author_facet | Domínguez Vigil, Irma Guadalupe Mata Cárdenas, Benito David Esquivel Ferriño, Patricia Cristina Avalos Alanís, Francisco Guadalupe Vargas Villarreal, Javier Camacho Corona, María del Rayo |
| author_sort | Domínguez Vigil, Irma Guadalupe |
| collection | Repositorio Institucional |
| description | Abstract: Foeniculum vulgare is used for the treatment of diarrhea in Mexican traditional medicine.
Hexane extract showed 94 % inhibition of Giardia duodenalis trophozoites at 300 µg/mL. Therefore, 20 constituents of hexane extract were evaluated to determine their antigiardial activity. Interestingly, six compounds showed good activity toward the parasite. These compounds were (1R,4S) (+)-Camphene (61%), (R)(−)-Carvone (66%), estragole (49%), p-anisaldehyde (67%), 1,3-benzenediol (56%), and trans, trans-2,4-undecadienal (97%). The aldehyde trans, trans-2,4-undecadienal was the most active compound with an IC50 value of 72.11 µg/mL against G. duodenalistrophozoites. This aldehyde was less toxic (IC50 588.8 µg/mL) than positive control metronidazole (IC50 83.5 µg/mL) against
Vero cells. The above results could support the use of F. vulgare in Mexican traditional medicine. |
| format | Article |
| id | eprints-27186 |
| institution | UANL |
| language | English |
| publishDate | 2022 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | eprints |
| spelling | eprints-271862024-12-09T18:08:20Z http://eprints.uanl.mx/27186/ Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents Domínguez Vigil, Irma Guadalupe Mata Cárdenas, Benito David Esquivel Ferriño, Patricia Cristina Avalos Alanís, Francisco Guadalupe Vargas Villarreal, Javier Camacho Corona, María del Rayo QD Química Abstract: Foeniculum vulgare is used for the treatment of diarrhea in Mexican traditional medicine. Hexane extract showed 94 % inhibition of Giardia duodenalis trophozoites at 300 µg/mL. Therefore, 20 constituents of hexane extract were evaluated to determine their antigiardial activity. Interestingly, six compounds showed good activity toward the parasite. These compounds were (1R,4S) (+)-Camphene (61%), (R)(−)-Carvone (66%), estragole (49%), p-anisaldehyde (67%), 1,3-benzenediol (56%), and trans, trans-2,4-undecadienal (97%). The aldehyde trans, trans-2,4-undecadienal was the most active compound with an IC50 value of 72.11 µg/mL against G. duodenalistrophozoites. This aldehyde was less toxic (IC50 588.8 µg/mL) than positive control metronidazole (IC50 83.5 µg/mL) against Vero cells. The above results could support the use of F. vulgare in Mexican traditional medicine. Multidisciplinary Digital Publishing Institute 2022 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/27186/7/27186.pdf.crdownload http://eprints.uanl.mx Domínguez Vigil, Irma Guadalupe y Mata Cárdenas, Benito David y Esquivel Ferriño, Patricia Cristina y Avalos Alanís, Francisco Guadalupe y Vargas Villarreal, Javier y Camacho Corona, María del Rayo (2022) Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents. Plants, 11 (17). pp. 1-7. ISSN 2223-7747 http://doi.org/10.3390/plants11172212 |
| spellingShingle | QD Química Domínguez Vigil, Irma Guadalupe Mata Cárdenas, Benito David Esquivel Ferriño, Patricia Cristina Avalos Alanís, Francisco Guadalupe Vargas Villarreal, Javier Camacho Corona, María del Rayo Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents |
| title_full | Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents |
| title_fullStr | Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents |
| title_full_unstemmed | Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents |
| title_short | Antigiardial Activity of Foeniculum vulgare Hexane Extract and Some of Its Constituents |
| title_sort | antigiardial activity of foeniculum vulgare hexane extract and some of its constituents |
| topic | QD Química |
| url | http://eprints.uanl.mx/27186/7/27186.pdf.crdownload |
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