In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants
Cancer is a major health problem with significant morbidity and mortality. In addition, plants are a source of metabolites with diverse biological properties, including antitumor potential. In this study, we investigated the in vitro murine lymphoma L5178Y-R cell growth inhibition, human peripheral...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/27005/7/27005.pdf |
| _version_ | 1824420633065291776 |
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| author | Rodríguez Garza, Nancy Edith Quintanilla Licea, Ramiro Romo Sáenz, César Iván Tamez Guerra, Patricia Rodríguez Padilla, Cristina Gómez Flores, Ricardo Alberto |
| author_facet | Rodríguez Garza, Nancy Edith Quintanilla Licea, Ramiro Romo Sáenz, César Iván Tamez Guerra, Patricia Rodríguez Padilla, Cristina Gómez Flores, Ricardo Alberto |
| author_sort | Rodríguez Garza, Nancy Edith |
| collection | Repositorio Institucional |
| description | Cancer is a major health problem with significant morbidity and mortality. In addition, plants are a source of metabolites with diverse biological properties, including antitumor potential. In this study, we investigated the in vitro murine lymphoma L5178Y-R cell growth inhibition, human peripheral blood mononuclear cells (PBMC) toxicity and proliferation, and antioxidant, hemolytic, and anti-hemolytic activities of methanol extracts from 15 plants of traditional use in Mexico. Justicia spicigera caused the highest tumor cell growth inhibition with a half maximal inhibitory concentration (IC50) of 29.10 ug/mL and a selectivity index >34.36 compared with those of PBMC, whereas Mimosa tenuiflora showed the highest lymphoproliferative activity from 200 ug/mL compared with that induced by concanavalin A. In addition, M. tenuiflora showed an antioxidant effect (IC50 = 2.86 ug/mL) higher than that of ascorbic acid. Regarding the hemolytic and anti-hemolytic activity, all extracts presented significant anti-hemolytic activity. The extract of J. spicigera is emerging as a possible source of effective antineoplastic compounds. |
| format | Article |
| id | eprints-27005 |
| institution | UANL |
| language | English |
| publishDate | 2023 |
| record_format | eprints |
| spelling | eprints-270052024-04-15T17:19:25Z http://eprints.uanl.mx/27005/ In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants Rodríguez Garza, Nancy Edith Quintanilla Licea, Ramiro Romo Sáenz, César Iván Tamez Guerra, Patricia Rodríguez Padilla, Cristina Gómez Flores, Ricardo Alberto QH Historia Natural, Biología Cancer is a major health problem with significant morbidity and mortality. In addition, plants are a source of metabolites with diverse biological properties, including antitumor potential. In this study, we investigated the in vitro murine lymphoma L5178Y-R cell growth inhibition, human peripheral blood mononuclear cells (PBMC) toxicity and proliferation, and antioxidant, hemolytic, and anti-hemolytic activities of methanol extracts from 15 plants of traditional use in Mexico. Justicia spicigera caused the highest tumor cell growth inhibition with a half maximal inhibitory concentration (IC50) of 29.10 ug/mL and a selectivity index >34.36 compared with those of PBMC, whereas Mimosa tenuiflora showed the highest lymphoproliferative activity from 200 ug/mL compared with that induced by concanavalin A. In addition, M. tenuiflora showed an antioxidant effect (IC50 = 2.86 ug/mL) higher than that of ascorbic acid. Regarding the hemolytic and anti-hemolytic activity, all extracts presented significant anti-hemolytic activity. The extract of J. spicigera is emerging as a possible source of effective antineoplastic compounds. 2023 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/27005/7/27005.pdf http://eprints.uanl.mx/27005/7.haspreviewThumbnailVersion/27005.pdf Rodríguez Garza, Nancy Edith y Quintanilla Licea, Ramiro y Romo Sáenz, César Iván y Tamez Guerra, Patricia y Rodríguez Padilla, Cristina y Gómez Flores, Ricardo Alberto (2023) In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants. Life. https://www.mdpi.com/2075-1729/13/4/958 |
| spellingShingle | QH Historia Natural, Biología Rodríguez Garza, Nancy Edith Quintanilla Licea, Ramiro Romo Sáenz, César Iván Tamez Guerra, Patricia Rodríguez Padilla, Cristina Gómez Flores, Ricardo Alberto In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants |
| title_full | In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants |
| title_fullStr | In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants |
| title_full_unstemmed | In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants |
| title_short | In Vitro Biological Activity and Lymphoma Cell Growth Inhibition by Selected Mexican Medicinal Plants |
| title_sort | in vitro biological activity and lymphoma cell growth inhibition by selected mexican medicinal plants |
| topic | QH Historia Natural, Biología |
| url | http://eprints.uanl.mx/27005/7/27005.pdf |
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