Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity
Riolozatrione (RZ) is a diterpenoid compound isolated from a dichloromethane extract of the Jatropha dioica root. This compound has been shown to possess moderate antiherpetic activity in vitro. However, because of the poor solubility of this compound in aqueous vehicles, generating a stable formula...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Croatian Pharmaceutical Society
2023
|
| Subjects: | |
| Online Access: | http://eprints.uanl.mx/26921/7/26921.pdf |
| _version_ | 1828850518512893952 |
|---|---|
| author | Solís Cruz, Guadalupe Yazmín Alvarez Román, Rocío Rivas Galindo, Verónica Mayela Galindo Rodríguez, Sergio Arturo Silva Mares, David Arturo Marino Martínez, Iván Alberto Escobar Saucedo, Magdalena Pérez López, Luis Alejandro |
| author_facet | Solís Cruz, Guadalupe Yazmín Alvarez Román, Rocío Rivas Galindo, Verónica Mayela Galindo Rodríguez, Sergio Arturo Silva Mares, David Arturo Marino Martínez, Iván Alberto Escobar Saucedo, Magdalena Pérez López, Luis Alejandro |
| author_sort | Solís Cruz, Guadalupe Yazmín |
| collection | Repositorio Institucional |
| description | Riolozatrione (RZ) is a diterpenoid compound isolated from a dichloromethane extract of the Jatropha dioica root. This compound has been shown to possess moderate antiherpetic activity in vitro. However, because of the poor solubility of this compound in aqueous vehicles, generating a stable formulation for potential use in the treatment of infection is challenging. The aim of this work was to optimize and physiochemically characterize Eudragit® L100-55-based polymeric nanoparticles (NPs) loaded with RZ (NPR) for in vitro antiherpetic application. The NPs formulation was initially optimized using the dichloromethane extract of J. dioica, the major component of which was RZ. The optimized NPR formulation was stable, with a size of 263 nm, polydispersity index < 0.2, the zeta potential of –37 mV, and RZ encapsulation efficiency of 89 %. The NPR showed sustained release of RZ for 48 h with release percentages of 95 and 97 % at neutral and slightly acidic pH, respectively. Regarding in vitro antiherpetic activity, the optimized NPR showed a selectivity index for HSV-1 of ≈16 and for HSV-2 of 13. |
| format | Article |
| id | eprints-26921 |
| institution | UANL |
| language | English |
| publishDate | 2023 |
| publisher | Croatian Pharmaceutical Society |
| record_format | eprints |
| spelling | eprints-269212025-04-07T20:16:41Z http://eprints.uanl.mx/26921/ Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity Solís Cruz, Guadalupe Yazmín Alvarez Román, Rocío Rivas Galindo, Verónica Mayela Galindo Rodríguez, Sergio Arturo Silva Mares, David Arturo Marino Martínez, Iván Alberto Escobar Saucedo, Magdalena Pérez López, Luis Alejandro QD Química Riolozatrione (RZ) is a diterpenoid compound isolated from a dichloromethane extract of the Jatropha dioica root. This compound has been shown to possess moderate antiherpetic activity in vitro. However, because of the poor solubility of this compound in aqueous vehicles, generating a stable formulation for potential use in the treatment of infection is challenging. The aim of this work was to optimize and physiochemically characterize Eudragit® L100-55-based polymeric nanoparticles (NPs) loaded with RZ (NPR) for in vitro antiherpetic application. The NPs formulation was initially optimized using the dichloromethane extract of J. dioica, the major component of which was RZ. The optimized NPR formulation was stable, with a size of 263 nm, polydispersity index < 0.2, the zeta potential of –37 mV, and RZ encapsulation efficiency of 89 %. The NPR showed sustained release of RZ for 48 h with release percentages of 95 and 97 % at neutral and slightly acidic pH, respectively. Regarding in vitro antiherpetic activity, the optimized NPR showed a selectivity index for HSV-1 of ≈16 and for HSV-2 of 13. Croatian Pharmaceutical Society 2023 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/26921/7/26921.pdf http://eprints.uanl.mx/26921/7.haspreviewThumbnailVersion/26921.pdf Solís Cruz, Guadalupe Yazmín y Alvarez Román, Rocío y Rivas Galindo, Verónica Mayela y Galindo Rodríguez, Sergio Arturo y Silva Mares, David Arturo y Marino Martínez, Iván Alberto y Escobar Saucedo, Magdalena y Pérez López, Luis Alejandro (2023) Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity. Acta Pharmaceutica, 73 (3). pp. 457-473. ISSN 1846-9558 http://doi.org/10.2478/acph-2023-0028 doi:10.2478/acph-2023-0028 |
| spellingShingle | QD Química Solís Cruz, Guadalupe Yazmín Alvarez Román, Rocío Rivas Galindo, Verónica Mayela Galindo Rodríguez, Sergio Arturo Silva Mares, David Arturo Marino Martínez, Iván Alberto Escobar Saucedo, Magdalena Pérez López, Luis Alejandro Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity |
| title_full | Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity |
| title_fullStr | Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity |
| title_full_unstemmed | Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity |
| title_short | Formulation and optimization of polymeric nanoparticles loaded with riolozatrione: a promising nanoformulation with potential antiherpetic activity |
| title_sort | formulation and optimization of polymeric nanoparticles loaded with riolozatrione a promising nanoformulation with potential antiherpetic activity |
| topic | QD Química |
| url | http://eprints.uanl.mx/26921/7/26921.pdf |
| work_keys_str_mv | AT soliscruzguadalupeyazmin formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT alvarezromanrocio formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT rivasgalindoveronicamayela formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT galindorodriguezsergioarturo formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT silvamaresdavidarturo formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT marinomartinezivanalberto formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT escobarsaucedomagdalena formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity AT perezlopezluisalejandro formulationandoptimizationofpolymericnanoparticlesloadedwithriolozatrioneapromisingnanoformulationwithpotentialantiherpeticactivity |