Changes in desmin and vimentin contenst after clofibrate treatment on rats
We analyzed in vivo effects of clofibrate and clofibric acid on vimentin and desmin content in rat myocardiocytes. Fifteen Sprague Dawley rats were divided in three groups of five animals each: clofibric acid, clofibrate, and untreated. After 30 days, the rats were sacrificed, the hearts excised, a...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2007
|
| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/25766/7/25766.pdf.crdownload |
| _version_ | 1824420303661432832 |
|---|---|
| author | Sampayo Reyes, Adriana Cortés Gutiérrez, Elva Irene Said Fernández, Salvador Luis Martínez Rodríguez, Herminia Guadalupe Narro Juárez, José Antonio Lozano Garza, Héctor Gerardo González Garza, María Teresa Mata Cárdenas, Benito David Vargas Villarreal, Javier Lazcano Martínez, Sigifredo González Martínez, Blanca Edelia Morales Aguilera, Antonio |
| author_facet | Sampayo Reyes, Adriana Cortés Gutiérrez, Elva Irene Said Fernández, Salvador Luis Martínez Rodríguez, Herminia Guadalupe Narro Juárez, José Antonio Lozano Garza, Héctor Gerardo González Garza, María Teresa Mata Cárdenas, Benito David Vargas Villarreal, Javier Lazcano Martínez, Sigifredo González Martínez, Blanca Edelia Morales Aguilera, Antonio |
| author_sort | Sampayo Reyes, Adriana |
| collection | Repositorio Institucional |
| description | We analyzed in vivo effects of clofibrate and clofibric acid on vimentin and desmin content in rat myocardiocytes. Fifteen Sprague Dawley rats were divided in three groups of five animals each: clofibric acid, clofibrate, and untreated. After 30 days, the rats were sacrificed, the
hearts excised, and the vimentin and desmin content was measured by Western blotting and densitometry. Clofibric acid treatment caused a 27.4% decrease in the amount of vimentin and a 49% decrease in desmin. With clofibrate, vimentin decreased 29.5% and desmin
decreased 48.7%. Moreover, we observed alterations in the cellular organization of the filaments of desmin and vimentin in all treated animals. Intermediate filaments are known to play a role in the anchoring and cellular organization of myocardiocytes. The adverse effects
of clofibrate and clofibric acid on patients may be partially due to decreased desmin and vimentin levels |
| format | Article |
| id | eprints-25766 |
| institution | UANL |
| language | English |
| publishDate | 2007 |
| record_format | eprints |
| spelling | eprints-257662024-12-11T15:16:43Z http://eprints.uanl.mx/25766/ Changes in desmin and vimentin contenst after clofibrate treatment on rats Sampayo Reyes, Adriana Cortés Gutiérrez, Elva Irene Said Fernández, Salvador Luis Martínez Rodríguez, Herminia Guadalupe Narro Juárez, José Antonio Lozano Garza, Héctor Gerardo González Garza, María Teresa Mata Cárdenas, Benito David Vargas Villarreal, Javier Lazcano Martínez, Sigifredo González Martínez, Blanca Edelia Morales Aguilera, Antonio QR Microbiología We analyzed in vivo effects of clofibrate and clofibric acid on vimentin and desmin content in rat myocardiocytes. Fifteen Sprague Dawley rats were divided in three groups of five animals each: clofibric acid, clofibrate, and untreated. After 30 days, the rats were sacrificed, the hearts excised, and the vimentin and desmin content was measured by Western blotting and densitometry. Clofibric acid treatment caused a 27.4% decrease in the amount of vimentin and a 49% decrease in desmin. With clofibrate, vimentin decreased 29.5% and desmin decreased 48.7%. Moreover, we observed alterations in the cellular organization of the filaments of desmin and vimentin in all treated animals. Intermediate filaments are known to play a role in the anchoring and cellular organization of myocardiocytes. The adverse effects of clofibrate and clofibric acid on patients may be partially due to decreased desmin and vimentin levels 2007 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/25766/7/25766.pdf.crdownload http://eprints.uanl.mx Sampayo Reyes, Adriana y Cortés Gutiérrez, Elva Irene y Said Fernández, Salvador Luis y Martínez Rodríguez, Herminia Guadalupe y Narro Juárez, José Antonio y Lozano Garza, Héctor Gerardo y González Garza, María Teresa y Mata Cárdenas, Benito David y Vargas Villarreal, Javier y Lazcano Martínez, Sigifredo y González Martínez, Blanca Edelia y Morales Aguilera, Antonio (2007) Changes in desmin and vimentin contenst after clofibrate treatment on rats. Pharmacologyonline, 3. pp. 255-268. ISSN 18278620 |
| spellingShingle | QR Microbiología Sampayo Reyes, Adriana Cortés Gutiérrez, Elva Irene Said Fernández, Salvador Luis Martínez Rodríguez, Herminia Guadalupe Narro Juárez, José Antonio Lozano Garza, Héctor Gerardo González Garza, María Teresa Mata Cárdenas, Benito David Vargas Villarreal, Javier Lazcano Martínez, Sigifredo González Martínez, Blanca Edelia Morales Aguilera, Antonio Changes in desmin and vimentin contenst after clofibrate treatment on rats |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Changes in desmin and vimentin contenst after clofibrate treatment on rats |
| title_full | Changes in desmin and vimentin contenst after clofibrate treatment on rats |
| title_fullStr | Changes in desmin and vimentin contenst after clofibrate treatment on rats |
| title_full_unstemmed | Changes in desmin and vimentin contenst after clofibrate treatment on rats |
| title_short | Changes in desmin and vimentin contenst after clofibrate treatment on rats |
| title_sort | changes in desmin and vimentin contenst after clofibrate treatment on rats |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/25766/7/25766.pdf.crdownload |
| work_keys_str_mv | AT sampayoreyesadriana changesindesminandvimentincontenstafterclofibratetreatmentonrats AT cortesgutierrezelvairene changesindesminandvimentincontenstafterclofibratetreatmentonrats AT saidfernandezsalvadorluis changesindesminandvimentincontenstafterclofibratetreatmentonrats AT martinezrodriguezherminiaguadalupe changesindesminandvimentincontenstafterclofibratetreatmentonrats AT narrojuarezjoseantonio changesindesminandvimentincontenstafterclofibratetreatmentonrats AT lozanogarzahectorgerardo changesindesminandvimentincontenstafterclofibratetreatmentonrats AT gonzalezgarzamariateresa changesindesminandvimentincontenstafterclofibratetreatmentonrats AT matacardenasbenitodavid changesindesminandvimentincontenstafterclofibratetreatmentonrats AT vargasvillarrealjavier changesindesminandvimentincontenstafterclofibratetreatmentonrats AT lazcanomartinezsigifredo changesindesminandvimentincontenstafterclofibratetreatmentonrats AT gonzalezmartinezblancaedelia changesindesminandvimentincontenstafterclofibratetreatmentonrats AT moralesaguileraantonio changesindesminandvimentincontenstafterclofibratetreatmentonrats |