Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration
Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4- related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Anatomical Pathology and Cytopathology Department
2020
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| Subjects: | |
| Online Access: | http://eprints.uanl.mx/25193/1/107.pdf |
| Summary: | Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the
upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4-
related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of the
relationship between EAF and IgG4-RD. Case Report: We report the case of a 37-year-old woman
with nasal deformity and facial pain. The lesion was surgically excised. Histological examination
revealed features of EAF with an IgG4/IgG plasma cell ratio >73% and 31 IgG4 stained cells per
high power field. No clinical or radiological recurrence was detected during follow-up. Serum
IgG4 quantification one year after surgery was within normal limits. Discussion: The relationship
between both entities may have therapeutic impact because IgG4-RD of the head and neck has a
high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this
infrequent disease are necessary to elucidate appropriate treatment and prognosis. |
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