Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration
Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4- related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Anatomical Pathology and Cytopathology Department
2020
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| Online Access: | http://eprints.uanl.mx/25193/1/107.pdf |
| _version_ | 1824420137399222272 |
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| author | Sáenz Ibarra, Bárbara Ceceñas Falcón, Luis Ángel Cárdenas de la Garza, J. A. Garza Elizondo, Mario Alberto De Hoyos R, Dieste Barboza Quintana, Oralia |
| author_facet | Sáenz Ibarra, Bárbara Ceceñas Falcón, Luis Ángel Cárdenas de la Garza, J. A. Garza Elizondo, Mario Alberto De Hoyos R, Dieste Barboza Quintana, Oralia |
| author_sort | Sáenz Ibarra, Bárbara |
| collection | Repositorio Institucional |
| description | Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the
upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4-
related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of the
relationship between EAF and IgG4-RD. Case Report: We report the case of a 37-year-old woman
with nasal deformity and facial pain. The lesion was surgically excised. Histological examination
revealed features of EAF with an IgG4/IgG plasma cell ratio >73% and 31 IgG4 stained cells per
high power field. No clinical or radiological recurrence was detected during follow-up. Serum
IgG4 quantification one year after surgery was within normal limits. Discussion: The relationship
between both entities may have therapeutic impact because IgG4-RD of the head and neck has a
high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this
infrequent disease are necessary to elucidate appropriate treatment and prognosis. |
| format | Article |
| id | eprints-25193 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| publisher | Anatomical Pathology and Cytopathology Department |
| record_format | eprints |
| spelling | eprints-251932023-03-16T15:07:00Z http://eprints.uanl.mx/25193/ Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration Sáenz Ibarra, Bárbara Ceceñas Falcón, Luis Ángel Cárdenas de la Garza, J. A. Garza Elizondo, Mario Alberto De Hoyos R, Dieste Barboza Quintana, Oralia R Medicina en General Introduction: Eosinophilic angiocentric fibrosis (EAF) is a rare lesion that predominantly affects the upper respiratory tract. Its etiology is unknown and it has been recently associated with the IgG4- related disease (IgG4-RD) spectrum. To the author’s knowledge, this is the sixth case report of the relationship between EAF and IgG4-RD. Case Report: We report the case of a 37-year-old woman with nasal deformity and facial pain. The lesion was surgically excised. Histological examination revealed features of EAF with an IgG4/IgG plasma cell ratio >73% and 31 IgG4 stained cells per high power field. No clinical or radiological recurrence was detected during follow-up. Serum IgG4 quantification one year after surgery was within normal limits. Discussion: The relationship between both entities may have therapeutic impact because IgG4-RD of the head and neck has a high remission rate with corticosteroids and immunosuppressive therapy. Additional reports of this infrequent disease are necessary to elucidate appropriate treatment and prognosis. Anatomical Pathology and Cytopathology Department 2020-04 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/25193/1/107.pdf http://eprints.uanl.mx/25193/1.haspreviewThumbnailVersion/107.pdf Sáenz Ibarra, Bárbara y Ceceñas Falcón, Luis Ángel y Cárdenas de la Garza, J. A. y Garza Elizondo, Mario Alberto y De Hoyos R, Dieste y Barboza Quintana, Oralia (2020) Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration. Malaysian J Pathol, 42 (1). pp. 137-141. |
| spellingShingle | R Medicina en General Sáenz Ibarra, Bárbara Ceceñas Falcón, Luis Ángel Cárdenas de la Garza, J. A. Garza Elizondo, Mario Alberto De Hoyos R, Dieste Barboza Quintana, Oralia Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration |
| title_full | Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration |
| title_fullStr | Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration |
| title_full_unstemmed | Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration |
| title_short | Nasal eosinophilic angiocentric fibrosis with IgG4-positive plasma cell infiltration |
| title_sort | nasal eosinophilic angiocentric fibrosis with igg4 positive plasma cell infiltration |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/25193/1/107.pdf |
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