Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method
Introduction: Urinalysis is one of the most important clinical laboratory tests because numerous pathologies can manifest or be suspected through this test. Although the previous reports mention that urinary microscopy is a fundamental part of urinalysis for diagnostic support of various conditions,...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/24680/7/24680.pdf |
| _version_ | 1824419637900607488 |
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| author | San Miguel Garay, Erik Alejandro Llaca Díaz, Jorge M. Robles Espino, Diana G Díaz Chuc, Erik A. Luna Falcón, Claudio Fabrizio Ayala de la Cruz, Sergio |
| author_facet | San Miguel Garay, Erik Alejandro Llaca Díaz, Jorge M. Robles Espino, Diana G Díaz Chuc, Erik A. Luna Falcón, Claudio Fabrizio Ayala de la Cruz, Sergio |
| author_sort | San Miguel Garay, Erik Alejandro |
| collection | Repositorio Institucional |
| description | Introduction: Urinalysis is one of the most important clinical laboratory tests because numerous pathologies can manifest or be suspected through this test. Although the previous reports mention that urinary microscopy is a fundamental part of urinalysis for diagnostic support of various conditions, there is a debate about the utility of this test section in a certain patient population. The aim of this study was to determine the diagnostic performance of the urinary dipstick analysis and the potential risks of false-negative (FN) results.
Material and methods: This is a retrospective and observational study, and urinalysis information was obtained from non-hospitalized patients. The dipstick and microscopic analyses were performed using the Clinitek-ATLAS (index test) and iQ200-SPRINT (reference standard) devices. Dipstick or microscopy analyses were positive if ≥ 1 parameters were abnormal. A Bayesian hierarchal beta-binomial model was carried out for each performance parameter. Risk analysis was performed as proposed in the literature.
Results: Five hundred and fifty-two patients were included in the study. The posterior median at group level was 94% (credible interval 95% [CrI 95%] 89.9-97%) for sensitivity (Se), 57.1% (CrI 95%, 50.1-64.1%) for specificity, and 5.8% (CrI 95%, 2.59-9.64%) for FN rate (FNR). The posterior probability Se > 90% was 95.9% at a group level. The risk analysis found only low-risk false-negative events.
Conclusions: The performance of the dipstick analysis was appropriate, with a good certainty of Se > 90% and a FNR < 10% at the operator level. Omission of microscopic analysis can be a safe action in a patient with a negative dipstick since FNs with a clinical impact are not expected. |
| format | Article |
| id | eprints-24680 |
| institution | UANL |
| language | English |
| publishDate | 2023 |
| record_format | eprints |
| spelling | eprints-246802023-01-31T21:49:43Z http://eprints.uanl.mx/24680/ Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method San Miguel Garay, Erik Alejandro Llaca Díaz, Jorge M. Robles Espino, Diana G Díaz Chuc, Erik A. Luna Falcón, Claudio Fabrizio Ayala de la Cruz, Sergio RB Patología Introduction: Urinalysis is one of the most important clinical laboratory tests because numerous pathologies can manifest or be suspected through this test. Although the previous reports mention that urinary microscopy is a fundamental part of urinalysis for diagnostic support of various conditions, there is a debate about the utility of this test section in a certain patient population. The aim of this study was to determine the diagnostic performance of the urinary dipstick analysis and the potential risks of false-negative (FN) results. Material and methods: This is a retrospective and observational study, and urinalysis information was obtained from non-hospitalized patients. The dipstick and microscopic analyses were performed using the Clinitek-ATLAS (index test) and iQ200-SPRINT (reference standard) devices. Dipstick or microscopy analyses were positive if ≥ 1 parameters were abnormal. A Bayesian hierarchal beta-binomial model was carried out for each performance parameter. Risk analysis was performed as proposed in the literature. Results: Five hundred and fifty-two patients were included in the study. The posterior median at group level was 94% (credible interval 95% [CrI 95%] 89.9-97%) for sensitivity (Se), 57.1% (CrI 95%, 50.1-64.1%) for specificity, and 5.8% (CrI 95%, 2.59-9.64%) for FN rate (FNR). The posterior probability Se > 90% was 95.9% at a group level. The risk analysis found only low-risk false-negative events. Conclusions: The performance of the dipstick analysis was appropriate, with a good certainty of Se > 90% and a FNR < 10% at the operator level. Omission of microscopic analysis can be a safe action in a patient with a negative dipstick since FNs with a clinical impact are not expected. 2023-01-05 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/24680/7/24680.pdf http://eprints.uanl.mx/24680/7.haspreviewThumbnailVersion/24680.pdf San Miguel Garay, Erik Alejandro y Llaca Díaz, Jorge M. y Robles Espino, Diana G y Díaz Chuc, Erik A. y Luna Falcón, Claudio Fabrizio y Ayala de la Cruz, Sergio (2023) Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method. Medicina universitaria, 24 (4). pp. 177-183. ISSN 1665-5796 https://www.medicinauniversitaria.org 10.24875/RMU.22000063 |
| spellingShingle | RB Patología San Miguel Garay, Erik Alejandro Llaca Díaz, Jorge M. Robles Espino, Diana G Díaz Chuc, Erik A. Luna Falcón, Claudio Fabrizio Ayala de la Cruz, Sergio Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method |
| title_full | Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method |
| title_fullStr | Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method |
| title_full_unstemmed | Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method |
| title_short | Urinalysis: diagnostic performance of urine dipstick compared to an automated microscopic method |
| title_sort | urinalysis diagnostic performance of urine dipstick compared to an automated microscopic method |
| topic | RB Patología |
| url | http://eprints.uanl.mx/24680/7/24680.pdf |
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