Probability of a successful platelet dose according to the number of platelet concentrates

Introduction: Platelet transfusion for prophylactic or therapeutic purposes is a common practice. The outcome evaluated in using platelets for prophylactic purposes has been preventing clinically significant bleeding. Transfusion guidelines recommend using platelet transfusion for prophylactic purpo...

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Autores principales: Llaca Díaz, Jorge Martín, Robles Espino, Diana Guadalupe, Díaz Chuc, Erik A., De la Rosa López, Alejandro, Ayala de la Cruz, Sergio
Formato: Artículo
Lenguaje:inglés
Publicado: 2022
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Acceso en línea:http://eprints.uanl.mx/24679/9/24679.pdf
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author Llaca Díaz, Jorge Martín
Robles Espino, Diana Guadalupe
Díaz Chuc, Erik A.
De la Rosa López, Alejandro
Ayala de la Cruz, Sergio
author_facet Llaca Díaz, Jorge Martín
Robles Espino, Diana Guadalupe
Díaz Chuc, Erik A.
De la Rosa López, Alejandro
Ayala de la Cruz, Sergio
author_sort Llaca Díaz, Jorge Martín
collection Repositorio Institucional
description Introduction: Platelet transfusion for prophylactic or therapeutic purposes is a common practice. The outcome evaluated in using platelets for prophylactic purposes has been preventing clinically significant bleeding. Transfusion guidelines recommend using platelet transfusion for prophylactic purposes based on the clinical scenario and a peripheral blood platelet threshold. Methods: A retrospective study was carried out, with the platelet count of the registry of quality control of platelet concentrates (PC), obtaining a total of 100. Age, sex, blood group, and peripheral blood platelets were compared with donors not included in quality control. The sum of the platelet count of all possible combinations of the 100 PCs was obtained for the 2-3 PCs scenarios and the 4-8 PCs scenarios, a simulation of 1,000,000 iterations with random sampling without replacement and the sum of the platelet count of the combinations obtained was performed. The proportion of successful doses in the distribution was obtained according to the number of PCs. Results: No statistically significant difference was found between donors included in quality control and those not included. The probability of administering a dose of ≥ 1.5 × 10^11 platelets is 97.33% and 99.99% for 3-4 PCs, respectively. Conclusions: This study may be useful for the physician who indicates PC for prophylactic purposes, using an appropriate number of PCs, and optimizing the available inventory.
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spelling eprints-246792024-03-07T18:39:49Z http://eprints.uanl.mx/24679/ Probability of a successful platelet dose according to the number of platelet concentrates Llaca Díaz, Jorge Martín Robles Espino, Diana Guadalupe Díaz Chuc, Erik A. De la Rosa López, Alejandro Ayala de la Cruz, Sergio RB Patología Introduction: Platelet transfusion for prophylactic or therapeutic purposes is a common practice. The outcome evaluated in using platelets for prophylactic purposes has been preventing clinically significant bleeding. Transfusion guidelines recommend using platelet transfusion for prophylactic purposes based on the clinical scenario and a peripheral blood platelet threshold. Methods: A retrospective study was carried out, with the platelet count of the registry of quality control of platelet concentrates (PC), obtaining a total of 100. Age, sex, blood group, and peripheral blood platelets were compared with donors not included in quality control. The sum of the platelet count of all possible combinations of the 100 PCs was obtained for the 2-3 PCs scenarios and the 4-8 PCs scenarios, a simulation of 1,000,000 iterations with random sampling without replacement and the sum of the platelet count of the combinations obtained was performed. The proportion of successful doses in the distribution was obtained according to the number of PCs. Results: No statistically significant difference was found between donors included in quality control and those not included. The probability of administering a dose of ≥ 1.5 × 10^11 platelets is 97.33% and 99.99% for 3-4 PCs, respectively. Conclusions: This study may be useful for the physician who indicates PC for prophylactic purposes, using an appropriate number of PCs, and optimizing the available inventory. 2022-10-20 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/24679/9/24679.pdf http://eprints.uanl.mx/24679/9.haspreviewThumbnailVersion/24679.pdf Llaca Díaz, Jorge Martín y Robles Espino, Diana Guadalupe y Díaz Chuc, Erik A. y De la Rosa López, Alejandro y Ayala de la Cruz, Sergio (2022) Probability of a successful platelet dose according to the number of platelet concentrates. Medicina universitaria, 24 (3). pp. 107-113. ISSN 1665-5796 https://www.medicinauniversitaria.org/index.php 10.24875/RMU.22000038
spellingShingle RB Patología
Llaca Díaz, Jorge Martín
Robles Espino, Diana Guadalupe
Díaz Chuc, Erik A.
De la Rosa López, Alejandro
Ayala de la Cruz, Sergio
Probability of a successful platelet dose according to the number of platelet concentrates
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Probability of a successful platelet dose according to the number of platelet concentrates
title_full Probability of a successful platelet dose according to the number of platelet concentrates
title_fullStr Probability of a successful platelet dose according to the number of platelet concentrates
title_full_unstemmed Probability of a successful platelet dose according to the number of platelet concentrates
title_short Probability of a successful platelet dose according to the number of platelet concentrates
title_sort probability of a successful platelet dose according to the number of platelet concentrates
topic RB Patología
url http://eprints.uanl.mx/24679/9/24679.pdf
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