Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models
Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability o...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/24017/1/24017.pdf |
| _version_ | 1824417091231416320 |
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| author | Wibetoe, Grunde Sexton, Joseph Ikdahl, Eirik Rollefstad, Silvia Kitas, George D. Riel, Piet van Gabriel, Sherine Kvien, Tore K. Douglas, Karen Sandoo, Aamer Arts, Elke E. Wållberg Jonsson, Solveig Rantapää Dahlqvist, Solbritt Karpouzas, George Dessein, Patrick H. Tsang, Linda El Gabalawy, Hani Hitchon, Carol A. Pascual Ramos, Virginia Contreas Yañes, Irazu Sfikakis, Petros P. González Gay, Miguel A. Colunga Pedraza, Iris Jazmín Galarza Delgado, Dionicio Ángel Azpiri López, José Ramón Crowson, Cynthia S. Grete Semb, Anne |
| author_facet | Wibetoe, Grunde Sexton, Joseph Ikdahl, Eirik Rollefstad, Silvia Kitas, George D. Riel, Piet van Gabriel, Sherine Kvien, Tore K. Douglas, Karen Sandoo, Aamer Arts, Elke E. Wållberg Jonsson, Solveig Rantapää Dahlqvist, Solbritt Karpouzas, George Dessein, Patrick H. Tsang, Linda El Gabalawy, Hani Hitchon, Carol A. Pascual Ramos, Virginia Contreas Yañes, Irazu Sfikakis, Petros P. González Gay, Miguel A. Colunga Pedraza, Iris Jazmín Galarza Delgado, Dionicio Ángel Azpiri López, José Ramón Crowson, Cynthia S. Grete Semb, Anne |
| author_sort | Wibetoe, Grunde |
| collection | Repositorio Institucional |
| description | Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive. |
| format | Article |
| id | eprints-24017 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| publisher | BioMed Central |
| record_format | eprints |
| spelling | eprints-240172024-12-09T18:08:56Z http://eprints.uanl.mx/24017/ Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models Wibetoe, Grunde Sexton, Joseph Ikdahl, Eirik Rollefstad, Silvia Kitas, George D. Riel, Piet van Gabriel, Sherine Kvien, Tore K. Douglas, Karen Sandoo, Aamer Arts, Elke E. Wållberg Jonsson, Solveig Rantapää Dahlqvist, Solbritt Karpouzas, George Dessein, Patrick H. Tsang, Linda El Gabalawy, Hani Hitchon, Carol A. Pascual Ramos, Virginia Contreas Yañes, Irazu Sfikakis, Petros P. González Gay, Miguel A. Colunga Pedraza, Iris Jazmín Galarza Delgado, Dionicio Ángel Azpiri López, José Ramón Crowson, Cynthia S. Grete Semb, Anne RC Medicina Interna, Psiquiatría, Neurología Background In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Secondly, we also evaluated the performance of risk age models in subgroups based on RA disease characteristics. Methods RA patients aged 30–70 years were included from an international consortium named A Trans-Atlantic Cardiovascular Consortium for Rheumatoid Arthritis (ATACC-RA). Prior CVD and diabetes mellitus were exclusion criteria. The discriminatory ability of specific risk age models was evaluated using c-statistics and their standard errors after calculating time until fatal or non-fatal CVD or last follow-up. Results A total of 1974 patients were included in the main analyses, and 144 events were observed during follow-up, the median follow-up being 5.0 years. The risk age models gave highly correlated results, demonstrating R 2 values ranging from 0.87 to 0.97. However, risk age estimations differed > 5 years in 15–32% of patients. C-statistics ranged 0.68–0.72 with standard errors of approximately 0.03. Despite certain RA characteristics being associated with low c-indices, standard errors were high. Restricting analysis to European RA patients yielded similar results. Conclusions The cardiovascular risk age and vascular age models have comparable performance in predicting CVD in RA patients. The influence of RA disease characteristics on the predictive ability of these prediction models remains inconclusive. BioMed Central 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/24017/1/24017.pdf http://eprints.uanl.mx/24017/1.haspreviewThumbnailVersion/24017.pdf Wibetoe, Grunde y Sexton, Joseph y Ikdahl, Eirik y Rollefstad, Silvia y Kitas, George D. y Riel, Piet van y Gabriel, Sherine y Kvien, Tore K. y Douglas, Karen y Sandoo, Aamer y Arts, Elke E. y Wållberg Jonsson, Solveig y Rantapää Dahlqvist, Solbritt y Karpouzas, George y Dessein, Patrick H. y Tsang, Linda y El Gabalawy, Hani y Hitchon, Carol A. y Pascual Ramos, Virginia y Contreas Yañes, Irazu y Sfikakis, Petros P. y González Gay, Miguel A. y Colunga Pedraza, Iris Jazmín y Galarza Delgado, Dionicio Ángel y Azpiri López, José Ramón y Crowson, Cynthia S. y Grete Semb, Anne (2020) Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models. Arthritis research & therapy, 22 (1). pp. 1-10. ISSN 1478-6354 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Wibetoe, Grunde Sexton, Joseph Ikdahl, Eirik Rollefstad, Silvia Kitas, George D. Riel, Piet van Gabriel, Sherine Kvien, Tore K. Douglas, Karen Sandoo, Aamer Arts, Elke E. Wållberg Jonsson, Solveig Rantapää Dahlqvist, Solbritt Karpouzas, George Dessein, Patrick H. Tsang, Linda El Gabalawy, Hani Hitchon, Carol A. Pascual Ramos, Virginia Contreas Yañes, Irazu Sfikakis, Petros P. González Gay, Miguel A. Colunga Pedraza, Iris Jazmín Galarza Delgado, Dionicio Ángel Azpiri López, José Ramón Crowson, Cynthia S. Grete Semb, Anne Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models |
| title_full | Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models |
| title_fullStr | Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models |
| title_full_unstemmed | Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models |
| title_short | Prediction of cardiovascular events in rheumatoid arthritis using risk age calculations: evaluation of concordance across risk age models |
| title_sort | prediction of cardiovascular events in rheumatoid arthritis using risk age calculations evaluation of concordance across risk age models |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/24017/1/24017.pdf |
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