In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity
Colloidal silver (AgC) is currently used by humans and it can be internalized through inhalation, injection, ingestion, and dermal contact. However, there is limited information about immunological activity; more investigations using colloidal silver are needed. In the present study, the effects of...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2016
|
| Subjects: | |
| Online Access: | http://eprints.uanl.mx/23570/1/23570.pdf |
| _version_ | 1838551005546938368 |
|---|---|
| author | Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Zárate Triviño, Diana Ginette Coronado Cerda, Erika Evangelina Alcocer González, Juan Manuel Reséndez Pérez, Diana Rodríguez Salazar, María del Carmen Rivera Morales, Lydia Guadalupe Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina |
| author_facet | Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Zárate Triviño, Diana Ginette Coronado Cerda, Erika Evangelina Alcocer González, Juan Manuel Reséndez Pérez, Diana Rodríguez Salazar, María del Carmen Rivera Morales, Lydia Guadalupe Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina |
| author_sort | Franco Molina, Moisés Armides |
| collection | Repositorio Institucional |
| description | Colloidal silver (AgC) is currently used by humans and it can be internalized through inhalation, injection, ingestion, and dermal contact. However, there is limited information about immunological activity; more investigations using colloidal silver are needed. In the present study, the effects of AgC (17.5 ng/mL) on immunological parameters (proliferation and immunophenotyping) using human peripheral blood mononuclear cells (PBMC) and macrophages (phagocytosis) and cytotoxicity on leukemia and lymphoma cancer cell lines (1.75 to 17.5 ng/mL) were investigated. AgC was observed to significantly (p<0.05) decrease interleukin-2 (IL-2) production and proliferation induced by phytohemagglutinin or concanavalin A in PBMC without affecting its cell viability but with cytotoxic effect on cancer cells. IL-2, IL-4, IL-6, IL-10, INF-γ, and IL-17A cytokines production and CD3+, CD3−CD19+, CD3+CD4+, CD3+CD8+, and CD16+CD56+ PBMC phenotypes were not affected by AgC. The present study demonstrates that colloidal silver is harmless and nontoxic to the immune system cells and its ability to interfere with the immune response by decreasing cell proliferation when stimulated with mitogens demonstrated the antilymphoproliferative potential of AgC. |
| format | Article |
| id | eprints-23570 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| record_format | eprints |
| spelling | eprints-235702025-07-18T17:19:45Z http://eprints.uanl.mx/23570/ In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Zárate Triviño, Diana Ginette Coronado Cerda, Erika Evangelina Alcocer González, Juan Manuel Reséndez Pérez, Diana Rodríguez Salazar, María del Carmen Rivera Morales, Lydia Guadalupe Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina R Medicina en General Colloidal silver (AgC) is currently used by humans and it can be internalized through inhalation, injection, ingestion, and dermal contact. However, there is limited information about immunological activity; more investigations using colloidal silver are needed. In the present study, the effects of AgC (17.5 ng/mL) on immunological parameters (proliferation and immunophenotyping) using human peripheral blood mononuclear cells (PBMC) and macrophages (phagocytosis) and cytotoxicity on leukemia and lymphoma cancer cell lines (1.75 to 17.5 ng/mL) were investigated. AgC was observed to significantly (p<0.05) decrease interleukin-2 (IL-2) production and proliferation induced by phytohemagglutinin or concanavalin A in PBMC without affecting its cell viability but with cytotoxic effect on cancer cells. IL-2, IL-4, IL-6, IL-10, INF-γ, and IL-17A cytokines production and CD3+, CD3−CD19+, CD3+CD4+, CD3+CD8+, and CD16+CD56+ PBMC phenotypes were not affected by AgC. The present study demonstrates that colloidal silver is harmless and nontoxic to the immune system cells and its ability to interfere with the immune response by decreasing cell proliferation when stimulated with mitogens demonstrated the antilymphoproliferative potential of AgC. Hindawi Publishing Corporation 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23570/1/23570.pdf http://eprints.uanl.mx/23570/1.haspreviewThumbnailVersion/23570.pdf Franco Molina, Moisés Armides y Mendoza Gamboa, Edgar y Zárate Triviño, Diana Ginette y Coronado Cerda, Erika Evangelina y Alcocer González, Juan Manuel y Reséndez Pérez, Diana y Rodríguez Salazar, María del Carmen y Rivera Morales, Lydia Guadalupe y Tamez Guerra, Reyes Silvestre y Rodríguez Padilla, Cristina (2016) In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity. Journal of Nanomaterials, 2016. pp. 1-8. ISSN 1687-4110 http://doi.org/10.1155/2016/4176212 doi:10.1155/2016/4176212 |
| spellingShingle | R Medicina en General Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Zárate Triviño, Diana Ginette Coronado Cerda, Erika Evangelina Alcocer González, Juan Manuel Reséndez Pérez, Diana Rodríguez Salazar, María del Carmen Rivera Morales, Lydia Guadalupe Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity |
| title_full | In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity |
| title_fullStr | In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity |
| title_full_unstemmed | In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity |
| title_short | In Vitro Evaluation of Colloidal Silver on Immune Function: Antilymphoproliferative Activity |
| title_sort | in vitro evaluation of colloidal silver on immune function antilymphoproliferative activity |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/23570/1/23570.pdf |
| work_keys_str_mv | AT francomolinamoisesarmides invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT mendozagamboaedgar invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT zaratetrivinodianaginette invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT coronadocerdaerikaevangelina invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT alcocergonzalezjuanmanuel invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT resendezperezdiana invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT rodriguezsalazarmariadelcarmen invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT riveramoraleslydiaguadalupe invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT tamezguerrareyessilvestre invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity AT rodriguezpadillacristina invitroevaluationofcolloidalsilveronimmunefunctionantilymphoproliferativeactivity |