Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discover...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Molecular Diversity Preservation International
2020
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/23563/1/23563.pdf |
| _version_ | 1824416929785315328 |
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| author | García Davis, Sara Leal López, Karla Ivette Molina Torres, Carmen Amelia Vera Cabrera, Lucio Díaz Marrero, Ana R. Fernández, José J. Carranza Rosales, Pilar Viveros Valdez, José Ezequiel |
| author_facet | García Davis, Sara Leal López, Karla Ivette Molina Torres, Carmen Amelia Vera Cabrera, Lucio Díaz Marrero, Ana R. Fernández, José J. Carranza Rosales, Pilar Viveros Valdez, José Ezequiel |
| author_sort | García Davis, Sara |
| collection | Repositorio Institucional |
| description | Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections. |
| format | Article |
| id | eprints-23563 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-235632024-03-05T18:02:31Z http://eprints.uanl.mx/23563/ Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii García Davis, Sara Leal López, Karla Ivette Molina Torres, Carmen Amelia Vera Cabrera, Lucio Díaz Marrero, Ana R. Fernández, José J. Carranza Rosales, Pilar Viveros Valdez, José Ezequiel QR Microbiología Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the identification of novel drugs based not only on newly discovered bioactive metabolites but also on already known compounds not yet thoroughly investigated. Since drug resistance has caused an increase in infections by Mycobacterium tuberculosis and nontuberculous mycobacteria, the re-evaluation of known bioactive metabolites has been suggested as a good approach to addressing this problem. In this sense, this study presents an evaluation of the in vitro effect of laurinterol and aplysin, two brominated sesquiterpenes isolated from Laurencia johnstonii, against nine M. tuberculosis strains and six nontuberculous mycobacteria (NTM). Laurinterol exhibited good antimycobacterial activity, especially against nontuberculous mycobacteria, being remarkable its effect against Mycobacterium abscessus, with minimum inhibitory concentration (MIC) values lower than those of the reference drug imipenem. This study provides further evidence for the antimycobacterial activity of some sesquiterpenes from L. johnstonii, which can be considered interesting lead compounds for the discovery of novel molecules to treat NTM infections. Molecular Diversity Preservation International 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23563/1/23563.pdf http://eprints.uanl.mx/23563/1.haspreviewThumbnailVersion/23563.pdf García Davis, Sara y Leal López, Karla Ivette y Molina Torres, Carmen Amelia y Vera Cabrera, Lucio y Díaz Marrero, Ana R. y Fernández, José J. y Carranza Rosales, Pilar y Viveros Valdez, José Ezequiel (2020) Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii. Marine drugs, 18. pp. 1-9. ISSN 1660-3397 http://doi.org/10.3390/md18060287 doi:10.3390/md18060287 |
| spellingShingle | QR Microbiología García Davis, Sara Leal López, Karla Ivette Molina Torres, Carmen Amelia Vera Cabrera, Lucio Díaz Marrero, Ana R. Fernández, José J. Carranza Rosales, Pilar Viveros Valdez, José Ezequiel Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii |
| title_full | Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii |
| title_fullStr | Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii |
| title_full_unstemmed | Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii |
| title_short | Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii |
| title_sort | antimycobacterial activity of laurinterol and aplysin from laurencia johnstonii |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/23563/1/23563.pdf |
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