Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults
We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine resear...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Molecular Diversity Preservation International
2021
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/23501/1/23501.pdf |
| _version_ | 1824416906761732096 |
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| author | Gallegos Cabriales, Esther Carlota Rodríguez Ayala, Ernesto Laviada Molina, Hugo A. Nava González, Edna Judith Salinas Osornio, Rocío A. Orozco, Lorena Leal Berumen, Irene Castillo Pineda, Juan Carlos González López, Laura Escudero Lourdes, Claudia Cornejo Barrera, Judith Escalante Araiza, Fabiola Huerta Ávila, Eira E. Buenfil Rello, Fatima A. Peschard, Vanessa Giselle Silva, Eliud Veloz Garza, Rosa A. Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Gonzalez Ramirez, Lucia Arjona Villicaña, Ruy D. Hernandez Escalante, Victor M. Gaytan Saucedo, Janeth F. Vaquera, Zoila Acebo Martinez, Mónica Lucía Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno Valencia Rendón, Melesio E. Garzon Zamora, Rafael Viveros Paredes, Juan Manuel Valdovinos Chávez, Salvador B. Comuzzie, Anthony G. Haack, Karin Thorsell, Ashley A. Han, Xianlin Cole, Shelley A. Bastarrachea, Raúl A. |
| author_facet | Gallegos Cabriales, Esther Carlota Rodríguez Ayala, Ernesto Laviada Molina, Hugo A. Nava González, Edna Judith Salinas Osornio, Rocío A. Orozco, Lorena Leal Berumen, Irene Castillo Pineda, Juan Carlos González López, Laura Escudero Lourdes, Claudia Cornejo Barrera, Judith Escalante Araiza, Fabiola Huerta Ávila, Eira E. Buenfil Rello, Fatima A. Peschard, Vanessa Giselle Silva, Eliud Veloz Garza, Rosa A. Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Gonzalez Ramirez, Lucia Arjona Villicaña, Ruy D. Hernandez Escalante, Victor M. Gaytan Saucedo, Janeth F. Vaquera, Zoila Acebo Martinez, Mónica Lucía Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno Valencia Rendón, Melesio E. Garzon Zamora, Rafael Viveros Paredes, Juan Manuel Valdovinos Chávez, Salvador B. Comuzzie, Anthony G. Haack, Karin Thorsell, Ashley A. Han, Xianlin Cole, Shelley A. Bastarrachea, Raúl A. |
| author_sort | Gallegos Cabriales, Esther Carlota |
| collection | Repositorio Institucional |
| description | We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine research project. Here we present integrative data replication of previous findings from an increased number of GEMM symptom-free (SF) adults (N = 124) to improve characterization of early biomarkers for cardiovascular (CV)/immunometabolic risk in SF adults with AT dysfunction. We achieved this goal by taking advantage of the rich set of GEMM F/P 5 h time course data and three tissue samples collected at the same time and frequency on each adult participant (F/P blood, biopsies of SQAT and skeletal muscle (SKM)). We classified them with the presence/absence of AT dysfunction: low (1) ALR. We also examined the presence of metabolically healthy (MH)/unhealthy (MUH) individuals through low-grade chronic subclinical inflammation (high sensitivity C-reactive protein (hsCRP)), whole body insulin sensitivity (Matsuda Index) and Metabolic Syndrome criteria in people with/without AT dysfunction. Molecular data directly measured from three tissues in a subset of participants allowed fine-scale multi-OMIC profiling of individual postprandial responses (RNA-seq in SKM and SQAT, miRNA from plasma exosomes and shotgun lipidomics in blood). Dynamic postprandial immunometabolic molecular endophenotypes were obtained to move towards a personalized, patient-defined medicine. This study offers an example of integrative translational research, which applies bench-to-bedside research to clinical medicine. Our F/P study design has the potential to characterize CV/immunometabolic early risk detection in support of precision medicine and discovery in SF individuals. |
| format | Article |
| id | eprints-23501 |
| institution | UANL |
| language | English |
| publishDate | 2021 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-235012024-03-04T16:08:57Z http://eprints.uanl.mx/23501/ Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults Gallegos Cabriales, Esther Carlota Rodríguez Ayala, Ernesto Laviada Molina, Hugo A. Nava González, Edna Judith Salinas Osornio, Rocío A. Orozco, Lorena Leal Berumen, Irene Castillo Pineda, Juan Carlos González López, Laura Escudero Lourdes, Claudia Cornejo Barrera, Judith Escalante Araiza, Fabiola Huerta Ávila, Eira E. Buenfil Rello, Fatima A. Peschard, Vanessa Giselle Silva, Eliud Veloz Garza, Rosa A. Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Gonzalez Ramirez, Lucia Arjona Villicaña, Ruy D. Hernandez Escalante, Victor M. Gaytan Saucedo, Janeth F. Vaquera, Zoila Acebo Martinez, Mónica Lucía Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno Valencia Rendón, Melesio E. Garzon Zamora, Rafael Viveros Paredes, Juan Manuel Valdovinos Chávez, Salvador B. Comuzzie, Anthony G. Haack, Karin Thorsell, Ashley A. Han, Xianlin Cole, Shelley A. Bastarrachea, Raúl A. QH Historia Natural, Biología We previously reported preliminary characterization of adipose tissue (AT) dysfunction through the adiponectin/leptin ratio (ALR) and fasting/postprandial (F/P) gene expression in subcutaneous (SQ) adipose tissue (AT) biopsies obtained from participants in the GEMM study, a precision medicine research project. Here we present integrative data replication of previous findings from an increased number of GEMM symptom-free (SF) adults (N = 124) to improve characterization of early biomarkers for cardiovascular (CV)/immunometabolic risk in SF adults with AT dysfunction. We achieved this goal by taking advantage of the rich set of GEMM F/P 5 h time course data and three tissue samples collected at the same time and frequency on each adult participant (F/P blood, biopsies of SQAT and skeletal muscle (SKM)). We classified them with the presence/absence of AT dysfunction: low (1) ALR. We also examined the presence of metabolically healthy (MH)/unhealthy (MUH) individuals through low-grade chronic subclinical inflammation (high sensitivity C-reactive protein (hsCRP)), whole body insulin sensitivity (Matsuda Index) and Metabolic Syndrome criteria in people with/without AT dysfunction. Molecular data directly measured from three tissues in a subset of participants allowed fine-scale multi-OMIC profiling of individual postprandial responses (RNA-seq in SKM and SQAT, miRNA from plasma exosomes and shotgun lipidomics in blood). Dynamic postprandial immunometabolic molecular endophenotypes were obtained to move towards a personalized, patient-defined medicine. This study offers an example of integrative translational research, which applies bench-to-bedside research to clinical medicine. Our F/P study design has the potential to characterize CV/immunometabolic early risk detection in support of precision medicine and discovery in SF individuals. Molecular Diversity Preservation International 2021 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23501/1/23501.pdf http://eprints.uanl.mx/23501/1.haspreviewThumbnailVersion/23501.pdf Gallegos Cabriales, Esther Carlota y Rodríguez Ayala, Ernesto y Laviada Molina, Hugo A. y Nava González, Edna Judith y Salinas Osornio, Rocío A. y Orozco, Lorena y Leal Berumen, Irene y Castillo Pineda, Juan Carlos y González López, Laura y Escudero Lourdes, Claudia y Cornejo Barrera, Judith y Escalante Araiza, Fabiola y Huerta Ávila, Eira E. y Buenfil Rello, Fatima A. y Peschard, Vanessa Giselle y Silva, Eliud y Veloz Garza, Rosa A. y Martínez Hernández, Angélica y Barajas Olmos, Francisco M. y Molina Segui, Fernanda y Gonzalez Ramirez, Lucia y Arjona Villicaña, Ruy D. y Hernandez Escalante, Victor M. y Gaytan Saucedo, Janeth F. y Vaquera, Zoila y Acebo Martinez, Mónica Lucía y Murillo Ramirez, Areli y Diaz Tena, Sara P. y Figueroa Nuñez, Benigno y Valencia Rendón, Melesio E. y Garzon Zamora, Rafael y Viveros Paredes, Juan Manuel y Valdovinos Chávez, Salvador B. y Comuzzie, Anthony G. y Haack, Karin y Thorsell, Ashley A. y Han, Xianlin y Cole, Shelley A. y Bastarrachea, Raúl A. (2021) Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults. Biology, 10 (12). pp. 1-20. ISSN 2079-7737 http://doi.org/10.3390/biology10121342 doi:10.3390/biology10121342 |
| spellingShingle | QH Historia Natural, Biología Gallegos Cabriales, Esther Carlota Rodríguez Ayala, Ernesto Laviada Molina, Hugo A. Nava González, Edna Judith Salinas Osornio, Rocío A. Orozco, Lorena Leal Berumen, Irene Castillo Pineda, Juan Carlos González López, Laura Escudero Lourdes, Claudia Cornejo Barrera, Judith Escalante Araiza, Fabiola Huerta Ávila, Eira E. Buenfil Rello, Fatima A. Peschard, Vanessa Giselle Silva, Eliud Veloz Garza, Rosa A. Martínez Hernández, Angélica Barajas Olmos, Francisco M. Molina Segui, Fernanda Gonzalez Ramirez, Lucia Arjona Villicaña, Ruy D. Hernandez Escalante, Victor M. Gaytan Saucedo, Janeth F. Vaquera, Zoila Acebo Martinez, Mónica Lucía Murillo Ramirez, Areli Diaz Tena, Sara P. Figueroa Nuñez, Benigno Valencia Rendón, Melesio E. Garzon Zamora, Rafael Viveros Paredes, Juan Manuel Valdovinos Chávez, Salvador B. Comuzzie, Anthony G. Haack, Karin Thorsell, Ashley A. Han, Xianlin Cole, Shelley A. Bastarrachea, Raúl A. Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults |
| title_full | Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults |
| title_fullStr | Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults |
| title_full_unstemmed | Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults |
| title_short | Replication of Integrative Data Analysis for Adipose Tissue Dysfunction, Low-Grade Inflammation, Postprandial Responses and OMICs Signatures in Symptom-Free Adults |
| title_sort | replication of integrative data analysis for adipose tissue dysfunction low grade inflammation postprandial responses and omics signatures in symptom free adults |
| topic | QH Historia Natural, Biología |
| url | http://eprints.uanl.mx/23501/1/23501.pdf |
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