Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold
This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology,...
| Autores principales: | , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Molecular Diversity Preservation International
2021
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/23496/1/23496.pdf |
| _version_ | 1824416905100787712 |
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| author | Campos Becerra, Luis Humberto Torres Castro, Alejandro |
| author_facet | Campos Becerra, Luis Humberto Torres Castro, Alejandro |
| author_sort | Campos Becerra, Luis Humberto |
| collection | Repositorio Institucional |
| description | This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in addition to possible applications in osteosynthesis, through contrib-uting to osseointegration and infection control through the release of drugs. Finally, another pos-sible attribute of this alloy could be its use as a complementary treatment for osteosarcoma; this is due to the basification produced by oxidative degradation (attack on cancer cells). The evaluation of cell viability of an alloy of Mg - 25 wt% Ca - 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considera-tions on the preparation of an alloy of Mg - 25 wt% Ca - 5 wt% Zn and its morphological charac-terization will help researchers understand its applicability for the development of new surgical techniques and lead to a deeper investigation of alternative treatments. However, it is very im-portant to bear in mind the mechanical effect of elements such as Ca and Zn on the degradation of the alloy matrix; the best alternative to predict the biological-mechanical potential starts with the selection of the essential-nutritional elements and their mechanical evaluation by mi-cro-indentation due to the fragility of the matrix. Therefore, the morphological evaluation of the specimens of Mg - 25 wt% Ca - 5 wt% Zn will show the crystallinity of the alloy; these results to-gether contribute to the design of biomedical alloys for use in treatments for various medical spe-cialties. The results indicated that cell viability is not affected, and there are no morphological changes in the cells. |
| format | Article |
| id | eprints-23496 |
| institution | UANL |
| language | English |
| publishDate | 2021 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-234962022-06-28T20:41:26Z http://eprints.uanl.mx/23496/ Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold Campos Becerra, Luis Humberto Torres Castro, Alejandro QD Química This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in addition to possible applications in osteosynthesis, through contrib-uting to osseointegration and infection control through the release of drugs. Finally, another pos-sible attribute of this alloy could be its use as a complementary treatment for osteosarcoma; this is due to the basification produced by oxidative degradation (attack on cancer cells). The evaluation of cell viability of an alloy of Mg - 25 wt% Ca - 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considera-tions on the preparation of an alloy of Mg - 25 wt% Ca - 5 wt% Zn and its morphological charac-terization will help researchers understand its applicability for the development of new surgical techniques and lead to a deeper investigation of alternative treatments. However, it is very im-portant to bear in mind the mechanical effect of elements such as Ca and Zn on the degradation of the alloy matrix; the best alternative to predict the biological-mechanical potential starts with the selection of the essential-nutritional elements and their mechanical evaluation by mi-cro-indentation due to the fragility of the matrix. Therefore, the morphological evaluation of the specimens of Mg - 25 wt% Ca - 5 wt% Zn will show the crystallinity of the alloy; these results to-gether contribute to the design of biomedical alloys for use in treatments for various medical spe-cialties. The results indicated that cell viability is not affected, and there are no morphological changes in the cells. Molecular Diversity Preservation International 2021 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23496/1/23496.pdf http://eprints.uanl.mx/23496/1.haspreviewThumbnailVersion/23496.pdf Campos Becerra, Luis Humberto y Torres Castro, Alejandro (2021) Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold. Crystals, 11. pp. 1-24. ISSN 2073-4352 http://doi.org/10.3390/cryst11111416 doi:10.3390/cryst11111416 |
| spellingShingle | QD Química Campos Becerra, Luis Humberto Torres Castro, Alejandro Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold |
| title_full | Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold |
| title_fullStr | Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold |
| title_full_unstemmed | Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold |
| title_short | Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold |
| title_sort | bio fabrication and experimental validation of an mg 25ca 5zn alloy proposed for a porous metallic scaffold |
| topic | QD Química |
| url | http://eprints.uanl.mx/23496/1/23496.pdf |
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