Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests
The COVID-19 pandemic has challenged healthcare systems worldwide. Efforts in low-to-middle-income countries (LMICs) cannot keep stride with infection rates, especially during peaks. A strong international collaboration between Arizona State University (ASU), Tec de Monterrey (TEC), and Servicios de...
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| Format: | Article |
| Language: | English |
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Molecular Diversity Preservation International
2022
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| Online Access: | http://eprints.uanl.mx/23474/1/23474.pdf |
| _version_ | 1824416897709375488 |
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| author | Sosa Hernández, Juan Eduardo Oyervides Muñoz, Mariel Araceli Melchor Martínez, Elda Madai Driver, Erin M. Bowes, Devin A. Kraberger, Simona Lucero Saucedo, Sofia Liliana Fontenele, Rafaela S. Parra Arroyo, Lizeth Holland, LaRinda A. Peña Benavides, Samantha Ayde Newell, Melanie Engstrom Martínez Ruiz, Manuel Adhikari, Sangeet Rodas Zuluaga, Laura Isabel Kumar, Rahul López Pacheco, Itzel Y. Castillo Zacarías, Carlos Jesús Iqbal, Hafiz M.N. Lim, Efrem S. Salas Limón, Daniel Varsani, Arvind Halden, Rolf U. Parra Saldívar, Roberto |
| author_facet | Sosa Hernández, Juan Eduardo Oyervides Muñoz, Mariel Araceli Melchor Martínez, Elda Madai Driver, Erin M. Bowes, Devin A. Kraberger, Simona Lucero Saucedo, Sofia Liliana Fontenele, Rafaela S. Parra Arroyo, Lizeth Holland, LaRinda A. Peña Benavides, Samantha Ayde Newell, Melanie Engstrom Martínez Ruiz, Manuel Adhikari, Sangeet Rodas Zuluaga, Laura Isabel Kumar, Rahul López Pacheco, Itzel Y. Castillo Zacarías, Carlos Jesús Iqbal, Hafiz M.N. Lim, Efrem S. Salas Limón, Daniel Varsani, Arvind Halden, Rolf U. Parra Saldívar, Roberto |
| author_sort | Sosa Hernández, Juan Eduardo |
| collection | Repositorio Institucional |
| description | The COVID-19 pandemic has challenged healthcare systems worldwide. Efforts in low-to-middle-income countries (LMICs) cannot keep stride with infection rates, especially during peaks. A strong international collaboration between Arizona State University (ASU), Tec de Monterrey (TEC), and Servicios de Agua y Drenaje de Monterrey (Local Water Utilities) is acting to integrate wastewater-based epidemiology (WBE) of SARS-CoV-2 in the region as a complementary approach to aid the healthcare system. Wastewater was collected from four sewer catchments in the Monterrey Metropolitan area in Mexico (pop. 4,643,232) from mid-April 2020 to February 2021 (44 weeks, n = 644). Raw wastewater was filtered and filter-concentrated, the RNA was extracted using columns, and the Charité/Berlin protocol was used for the RT-qPCR. The viral loads obtained between the first (June 2020) and second waves (February 2021) of the pandemic were similar; in contrast, the clinical cases were fewer during the first wave, indicating poor coverage. During the second wave of the pandemic, the SARS-CoV-2 quantification in wastewater increased 14 days earlier than the COVID-19 clinical cases reported. This is the first long-term WBE study in Mexico and demonstrates its value in pandemic management. |
| format | Article |
| id | eprints-23474 |
| institution | UANL |
| language | English |
| publishDate | 2022 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-234742024-03-05T16:46:50Z http://eprints.uanl.mx/23474/ Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests Sosa Hernández, Juan Eduardo Oyervides Muñoz, Mariel Araceli Melchor Martínez, Elda Madai Driver, Erin M. Bowes, Devin A. Kraberger, Simona Lucero Saucedo, Sofia Liliana Fontenele, Rafaela S. Parra Arroyo, Lizeth Holland, LaRinda A. Peña Benavides, Samantha Ayde Newell, Melanie Engstrom Martínez Ruiz, Manuel Adhikari, Sangeet Rodas Zuluaga, Laura Isabel Kumar, Rahul López Pacheco, Itzel Y. Castillo Zacarías, Carlos Jesús Iqbal, Hafiz M.N. Lim, Efrem S. Salas Limón, Daniel Varsani, Arvind Halden, Rolf U. Parra Saldívar, Roberto RA Aspectos Públicos de la Medicina The COVID-19 pandemic has challenged healthcare systems worldwide. Efforts in low-to-middle-income countries (LMICs) cannot keep stride with infection rates, especially during peaks. A strong international collaboration between Arizona State University (ASU), Tec de Monterrey (TEC), and Servicios de Agua y Drenaje de Monterrey (Local Water Utilities) is acting to integrate wastewater-based epidemiology (WBE) of SARS-CoV-2 in the region as a complementary approach to aid the healthcare system. Wastewater was collected from four sewer catchments in the Monterrey Metropolitan area in Mexico (pop. 4,643,232) from mid-April 2020 to February 2021 (44 weeks, n = 644). Raw wastewater was filtered and filter-concentrated, the RNA was extracted using columns, and the Charité/Berlin protocol was used for the RT-qPCR. The viral loads obtained between the first (June 2020) and second waves (February 2021) of the pandemic were similar; in contrast, the clinical cases were fewer during the first wave, indicating poor coverage. During the second wave of the pandemic, the SARS-CoV-2 quantification in wastewater increased 14 days earlier than the COVID-19 clinical cases reported. This is the first long-term WBE study in Mexico and demonstrates its value in pandemic management. Molecular Diversity Preservation International 2022 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23474/1/23474.pdf http://eprints.uanl.mx/23474/1.haspreviewThumbnailVersion/23474.pdf Sosa Hernández, Juan Eduardo y Oyervides Muñoz, Mariel Araceli y Melchor Martínez, Elda Madai y Driver, Erin M. y Bowes, Devin A. y Kraberger, Simona y Lucero Saucedo, Sofia Liliana y Fontenele, Rafaela S. y Parra Arroyo, Lizeth y Holland, LaRinda A. y Peña Benavides, Samantha Ayde y Newell, Melanie Engstrom y Martínez Ruiz, Manuel y Adhikari, Sangeet y Rodas Zuluaga, Laura Isabel y Kumar, Rahul y López Pacheco, Itzel Y. y Castillo Zacarías, Carlos Jesús y Iqbal, Hafiz M.N. y Lim, Efrem S. y Salas Limón, Daniel y Varsani, Arvind y Halden, Rolf U. y Parra Saldívar, Roberto (2022) Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests. Water, 14 (12). pp. 1-12. ISSN 2073-4441 http://doi.org/10.3390/w14121842 doi:10.3390/w14121842 |
| spellingShingle | RA Aspectos Públicos de la Medicina Sosa Hernández, Juan Eduardo Oyervides Muñoz, Mariel Araceli Melchor Martínez, Elda Madai Driver, Erin M. Bowes, Devin A. Kraberger, Simona Lucero Saucedo, Sofia Liliana Fontenele, Rafaela S. Parra Arroyo, Lizeth Holland, LaRinda A. Peña Benavides, Samantha Ayde Newell, Melanie Engstrom Martínez Ruiz, Manuel Adhikari, Sangeet Rodas Zuluaga, Laura Isabel Kumar, Rahul López Pacheco, Itzel Y. Castillo Zacarías, Carlos Jesús Iqbal, Hafiz M.N. Lim, Efrem S. Salas Limón, Daniel Varsani, Arvind Halden, Rolf U. Parra Saldívar, Roberto Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests |
| title_full | Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests |
| title_fullStr | Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests |
| title_full_unstemmed | Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests |
| title_short | Extensive Wastewater-Based Epidemiology as a Resourceful Tool for SARS-CoV-2 Surveillance in a Low-to-Middle-Income Country through a Successful Collaborative Quest: WBE, Mobility, and Clinical Tests |
| title_sort | extensive wastewater based epidemiology as a resourceful tool for sars cov 2 surveillance in a low to middle income country through a successful collaborative quest wbe mobility and clinical tests |
| topic | RA Aspectos Públicos de la Medicina |
| url | http://eprints.uanl.mx/23474/1/23474.pdf |
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