Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma
The objective of this study was to compare the antitumor activity of lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine (CHX) on human squamous cell carcinoma. BisBAL NPs were synthesized by colloidal method and characterized by energy dispersive X-ray spectroscopy in conjunction with s...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Hindawi Publishing Corporation
2019
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/23471/1/23471.pdf |
| _version_ | 1824416896413335552 |
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| author | Martínez Pérez, Fernando García Cuellar, Claudia María Hernández Delgadillo, René Zaragoza Magaña, Valentín Sánchez Pérez, Yesennia Meester, Irene Nakagoshi Cepeda, Sergio Eduardo Solís Soto, Juan Manuel Nakagoshi Cepeda, María Argelia Akemi Chellam, Shankararaman Cabral Romero, Claudio |
| author_facet | Martínez Pérez, Fernando García Cuellar, Claudia María Hernández Delgadillo, René Zaragoza Magaña, Valentín Sánchez Pérez, Yesennia Meester, Irene Nakagoshi Cepeda, Sergio Eduardo Solís Soto, Juan Manuel Nakagoshi Cepeda, María Argelia Akemi Chellam, Shankararaman Cabral Romero, Claudio |
| author_sort | Martínez Pérez, Fernando |
| collection | Repositorio Institucional |
| description | The objective of this study was to compare the antitumor activity of lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine (CHX) on human squamous cell carcinoma. BisBAL NPs were synthesized by colloidal method and characterized by energy dispersive X-ray spectroscopy in conjunction with scanning electron microscopy (EDS-SEM). The effect of BisBAL NPs and CHX on oral cancer cell line (CAL-27) and nontumor control cell human gingival fibroblasts (HGFs) was determined by MTT cell viability assay. The obtained results showed selective inhibition of CAL-27 cell growth by BisBAL nanoclusters. A 24 h exposition to 25 μM BisBAL NP decreased 91% of CAL-27 cell growth, while nontumor HGFs cells were unaffected by BisBAL NPs showing 90% of cell viability. In contrast, CHX kills both CAL-27 and HGFs with the same efficacy. 25 μM of CHX decreased 97% and 80% of tumor and nontumoral cell growth. BisBAL NP and CHX alter cell permeability suggesting that action mechanism may include loss of cell membrane integrity. Also, CHX and not BisBAL NP presented genotoxicity on genomic DNA of tumor cells. As conclusion, BisBAL NPs have a selective antitumor activity on human squamous cell carcinoma, unlike CHX which was cytotoxic for both tumoral and nontumoral control cells. |
| format | Article |
| id | eprints-23471 |
| institution | UANL |
| language | English |
| publishDate | 2019 |
| publisher | Hindawi Publishing Corporation |
| record_format | eprints |
| spelling | eprints-234712022-06-24T20:19:19Z http://eprints.uanl.mx/23471/ Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma Martínez Pérez, Fernando García Cuellar, Claudia María Hernández Delgadillo, René Zaragoza Magaña, Valentín Sánchez Pérez, Yesennia Meester, Irene Nakagoshi Cepeda, Sergio Eduardo Solís Soto, Juan Manuel Nakagoshi Cepeda, María Argelia Akemi Chellam, Shankararaman Cabral Romero, Claudio RK Odontología The objective of this study was to compare the antitumor activity of lipophilic bismuth nanoparticles (BisBAL NPs) and chlorhexidine (CHX) on human squamous cell carcinoma. BisBAL NPs were synthesized by colloidal method and characterized by energy dispersive X-ray spectroscopy in conjunction with scanning electron microscopy (EDS-SEM). The effect of BisBAL NPs and CHX on oral cancer cell line (CAL-27) and nontumor control cell human gingival fibroblasts (HGFs) was determined by MTT cell viability assay. The obtained results showed selective inhibition of CAL-27 cell growth by BisBAL nanoclusters. A 24 h exposition to 25 μM BisBAL NP decreased 91% of CAL-27 cell growth, while nontumor HGFs cells were unaffected by BisBAL NPs showing 90% of cell viability. In contrast, CHX kills both CAL-27 and HGFs with the same efficacy. 25 μM of CHX decreased 97% and 80% of tumor and nontumoral cell growth. BisBAL NP and CHX alter cell permeability suggesting that action mechanism may include loss of cell membrane integrity. Also, CHX and not BisBAL NP presented genotoxicity on genomic DNA of tumor cells. As conclusion, BisBAL NPs have a selective antitumor activity on human squamous cell carcinoma, unlike CHX which was cytotoxic for both tumoral and nontumoral control cells. Hindawi Publishing Corporation 2019 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23471/1/23471.pdf http://eprints.uanl.mx/23471/1.haspreviewThumbnailVersion/23471.pdf Martínez Pérez, Fernando y García Cuellar, Claudia María y Hernández Delgadillo, René y Zaragoza Magaña, Valentín y Sánchez Pérez, Yesennia y Meester, Irene y Nakagoshi Cepeda, Sergio Eduardo y Solís Soto, Juan Manuel y Nakagoshi Cepeda, María Argelia Akemi y Chellam, Shankararaman y Cabral Romero, Claudio (2019) Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma. Journal of Nanomaterials, 2019. pp. 1-8. ISSN 1687-4110 http://doi.org/10.1155/2019/8148219 doi:10.1155/2019/8148219 |
| spellingShingle | RK Odontología Martínez Pérez, Fernando García Cuellar, Claudia María Hernández Delgadillo, René Zaragoza Magaña, Valentín Sánchez Pérez, Yesennia Meester, Irene Nakagoshi Cepeda, Sergio Eduardo Solís Soto, Juan Manuel Nakagoshi Cepeda, María Argelia Akemi Chellam, Shankararaman Cabral Romero, Claudio Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma |
| title_full | Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma |
| title_fullStr | Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma |
| title_full_unstemmed | Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma |
| title_short | Comparative Study of Antitumor Activity between Lipophilic Bismuth Nanoparticles (BisBAL NPs) and Chlorhexidine on Human Squamous Cell Carcinoma |
| title_sort | comparative study of antitumor activity between lipophilic bismuth nanoparticles bisbal nps and chlorhexidine on human squamous cell carcinoma |
| topic | RK Odontología |
| url | http://eprints.uanl.mx/23471/1/23471.pdf |
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