Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione
The title compound, C21H24N4O2, is a potent serotonin 5-HT2 and α1-adrenoceptor antagonist. The n-propyl chain links the quinazolinedione heterocycle and the phenylpiperazine group in which the benzene ring is equatorially located and the piperazine ring has the expected chair conformation. The dihe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley-Blackwell
2014
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| Subjects: | |
| Online Access: | http://eprints.uanl.mx/23369/1/23369.pdf |
| _version_ | 1824416856422744064 |
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| author | Aguirre Hernández, Gerardo Somanathan, Ratnasamy Bernès, Sylvain |
| author_facet | Aguirre Hernández, Gerardo Somanathan, Ratnasamy Bernès, Sylvain |
| author_sort | Aguirre Hernández, Gerardo |
| collection | Repositorio Institucional |
| description | The title compound, C21H24N4O2, is a potent serotonin 5-HT2 and α1-adrenoceptor antagonist. The n-propyl chain links the quinazolinedione heterocycle and the phenylpiperazine group in which the benzene ring is equatorially located and the piperazine ring has the expected chair conformation. The dihedral angle between the planes of the benzene ring and the quinazolinedione ring system is 74.1 (1)°. In the crystal, molecules form centrosymmetric dimers through R22(8) hydrogen-bonded rings involving the amine and one carbonyl group of the quinazolinedione moiety. These dimers are extended into chains extending along the a-axis direction through expanded centrosymmetric cyclic C—H...O associations involving the second carbonyl group, giving R22(20) and R12(7) motifs. |
| format | Article |
| id | eprints-23369 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| publisher | Wiley-Blackwell |
| record_format | eprints |
| spelling | eprints-233692022-06-07T20:44:51Z http://eprints.uanl.mx/23369/ Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione Aguirre Hernández, Gerardo Somanathan, Ratnasamy Bernès, Sylvain QD Química The title compound, C21H24N4O2, is a potent serotonin 5-HT2 and α1-adrenoceptor antagonist. The n-propyl chain links the quinazolinedione heterocycle and the phenylpiperazine group in which the benzene ring is equatorially located and the piperazine ring has the expected chair conformation. The dihedral angle between the planes of the benzene ring and the quinazolinedione ring system is 74.1 (1)°. In the crystal, molecules form centrosymmetric dimers through R22(8) hydrogen-bonded rings involving the amine and one carbonyl group of the quinazolinedione moiety. These dimers are extended into chains extending along the a-axis direction through expanded centrosymmetric cyclic C—H...O associations involving the second carbonyl group, giving R22(20) and R12(7) motifs. Wiley-Blackwell 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23369/1/23369.pdf http://eprints.uanl.mx/23369/1.haspreviewThumbnailVersion/23369.pdf Aguirre Hernández, Gerardo y Somanathan, Ratnasamy y Bernès, Sylvain (2014) Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione. Acta crystallographica. Section E, 70 (8). o878-o878. ISSN 1600-5368 http://doi.org/10.1107/S160053681401602X doi:10.1107/S160053681401602X |
| spellingShingle | QD Química Aguirre Hernández, Gerardo Somanathan, Ratnasamy Bernès, Sylvain Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione |
| title_full | Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione |
| title_fullStr | Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione |
| title_full_unstemmed | Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione |
| title_short | Pelanserin: 3-[3-(4-phenylpiperazin-1-yl)propyl]quinazoline-2,4(1H,3H)-dione |
| title_sort | pelanserin 3 3 4 phenylpiperazin 1 yl propyl quinazoline 2 4 1h 3h dione |
| topic | QD Química |
| url | http://eprints.uanl.mx/23369/1/23369.pdf |
| work_keys_str_mv | AT aguirrehernandezgerardo pelanserin334phenylpiperazin1ylpropylquinazoline241h3hdione AT somanathanratnasamy pelanserin334phenylpiperazin1ylpropylquinazoline241h3hdione AT bernessylvain pelanserin334phenylpiperazin1ylpropylquinazoline241h3hdione |