Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study
Introduction Observational studies constitute an important evidence base for hypoglycemia in diabetes management. This requires consistent and reliable ascertainment and reporting methodology, particularly in studies of type 2 diabetes where hypoglycemia risk is heterogeneous. Therefore, we aimed to...
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| Formato: | Artículo |
| Lenguaje: | inglés |
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BMJ Publishing Group
2021
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| Acceso en línea: | http://eprints.uanl.mx/23366/1/23366.pdf |
| _version_ | 1824416855606951936 |
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| author | Rodríguez Gutiérrez, René Salcido Montenegro, Alejandro González González, José Gerardo McCoy, Rozalina G |
| author_facet | Rodríguez Gutiérrez, René Salcido Montenegro, Alejandro González González, José Gerardo McCoy, Rozalina G |
| author_sort | Rodríguez Gutiérrez, René |
| collection | Repositorio Institucional |
| description | Introduction Observational studies constitute an important evidence base for hypoglycemia in diabetes management. This requires consistent and reliable ascertainment and reporting methodology, particularly in studies of type 2 diabetes where hypoglycemia risk is heterogeneous. Therefore, we aimed to examine the definitions of hypoglycemia used by observational studies of patients with type 2 diabetes. Research design and methods We conducted a meta-epidemiological review of observational studies reporting on hypoglycemia or evaluating glucose-lowering medications in adults with type 2 diabetes. MEDLINE and Google Scholar were searched from January 1970 to May 2018. The definitions of non-severe, severe and nocturnal hypoglycemia were examined.Results We reviewed 243 studies: 47.7% reported on non-severe hypoglycemia, 77.8% on severe hypoglycemia and 16.9% on nocturnal hypoglycemia; 5.8% did not specify. Among 116 studies reporting non-severe hypoglycemia, 18.1% provided no definition, 23.3% used glucose values, 38.8% relied on patient-reported symptoms, 17.2% accepted either glucose values or patient-reported symptoms and 2.6% relied on International Classification of Disease (ICD) codes. Among 189 studies reporting severe hypoglycemia, 11.1% provided no definition, 53.4% required symptoms needing assistance, 3.7% relied on glucose values, 14.8% relied on ICD codes, 2.6% relied on ICD codes or glucose values and 15.9% required both symptoms needing assistance and glucose values. Overall, 38.2% of non-severe and 67.7% of severe hypoglycemia definitions were consistent with the International Hypoglycemia Study Group.Conclusions The marked heterogeneity in how hypoglycemia is defined in observational studies may contribute to the inadequate understanding and correction of hypoglycemia risk factors among patients with type 2 diabetes. |
| format | Article |
| id | eprints-23366 |
| institution | UANL |
| language | English |
| publishDate | 2021 |
| publisher | BMJ Publishing Group |
| record_format | eprints |
| spelling | eprints-233662024-12-11T14:33:14Z http://eprints.uanl.mx/23366/ Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study Rodríguez Gutiérrez, René Salcido Montenegro, Alejandro González González, José Gerardo McCoy, Rozalina G RC Medicina Interna, Psiquiatría, Neurología Introduction Observational studies constitute an important evidence base for hypoglycemia in diabetes management. This requires consistent and reliable ascertainment and reporting methodology, particularly in studies of type 2 diabetes where hypoglycemia risk is heterogeneous. Therefore, we aimed to examine the definitions of hypoglycemia used by observational studies of patients with type 2 diabetes. Research design and methods We conducted a meta-epidemiological review of observational studies reporting on hypoglycemia or evaluating glucose-lowering medications in adults with type 2 diabetes. MEDLINE and Google Scholar were searched from January 1970 to May 2018. The definitions of non-severe, severe and nocturnal hypoglycemia were examined.Results We reviewed 243 studies: 47.7% reported on non-severe hypoglycemia, 77.8% on severe hypoglycemia and 16.9% on nocturnal hypoglycemia; 5.8% did not specify. Among 116 studies reporting non-severe hypoglycemia, 18.1% provided no definition, 23.3% used glucose values, 38.8% relied on patient-reported symptoms, 17.2% accepted either glucose values or patient-reported symptoms and 2.6% relied on International Classification of Disease (ICD) codes. Among 189 studies reporting severe hypoglycemia, 11.1% provided no definition, 53.4% required symptoms needing assistance, 3.7% relied on glucose values, 14.8% relied on ICD codes, 2.6% relied on ICD codes or glucose values and 15.9% required both symptoms needing assistance and glucose values. Overall, 38.2% of non-severe and 67.7% of severe hypoglycemia definitions were consistent with the International Hypoglycemia Study Group.Conclusions The marked heterogeneity in how hypoglycemia is defined in observational studies may contribute to the inadequate understanding and correction of hypoglycemia risk factors among patients with type 2 diabetes. BMJ Publishing Group 2021 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23366/1/23366.pdf http://eprints.uanl.mx/23366/1.haspreviewThumbnailVersion/23366.pdf Rodríguez Gutiérrez, René y Salcido Montenegro, Alejandro y González González, José Gerardo y McCoy, Rozalina G (2021) Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study. BMJ Open Diabetes Research & Care, 9 (1). pp. 1-7. ISSN 2052-4897 http://doi.org/10.1136/bmjdrc-2020-001906 doi:10.1136/bmjdrc-2020-001906 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Rodríguez Gutiérrez, René Salcido Montenegro, Alejandro González González, José Gerardo McCoy, Rozalina G Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study |
| title_full | Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study |
| title_fullStr | Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study |
| title_full_unstemmed | Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study |
| title_short | Variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies: a meta-epidemiological study |
| title_sort | variation in hypoglycemia ascertainment and report in type 2 diabetes observational studies a meta epidemiological study |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/23366/1/23366.pdf |
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