Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing
Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the e...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Molecular Diversity Preservation International
2020
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/23324/1/23324.pdf |
| _version_ | 1824416841660891136 |
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| author | López Calderón, Héctor Daniel Avilés Arnaut, Hamlet Galán Wong, Luis Jesús Almaguer Cantú, Verónica Laguna Camacho, J. R. Calderón Ramón, C. Escalante Martínez, J. E. Arévalo Niño, Katiushka |
| author_facet | López Calderón, Héctor Daniel Avilés Arnaut, Hamlet Galán Wong, Luis Jesús Almaguer Cantú, Verónica Laguna Camacho, J. R. Calderón Ramón, C. Escalante Martínez, J. E. Arévalo Niño, Katiushka |
| author_sort | López Calderón, Héctor Daniel |
| collection | Repositorio Institucional |
| description | Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the electrospinning process were standardized for voltage parameters, feed flow and the distance from the injector to the collector. Once the values of the main variables for the electrospinning were optimized, a three-hour processing time was established to allow the separation of the material from the collector. The obtained material was characterized by observations on scanning electron microscopy, Fourier transform infrared spectroscopy and thermal analysis; contact angle measurement was performed to evaluate wettability properties, and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated using the Kirby–Bauer test. The obtained fibers that form the bi-layer scaffold present diameters from 100 to 300 nm. The scaffold presents chemical composition, thermal stability, wettability characteristics and antibacterial activity that fulfill the proposal from this study, based on obtaining a scaffold that could be used as a drug delivery vehicle and a wound dressing material. |
| format | Article |
| id | eprints-23324 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-233242024-03-05T16:33:53Z http://eprints.uanl.mx/23324/ Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing López Calderón, Héctor Daniel Avilés Arnaut, Hamlet Galán Wong, Luis Jesús Almaguer Cantú, Verónica Laguna Camacho, J. R. Calderón Ramón, C. Escalante Martínez, J. E. Arévalo Niño, Katiushka TP Tecnología Química Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the electrospinning process were standardized for voltage parameters, feed flow and the distance from the injector to the collector. Once the values of the main variables for the electrospinning were optimized, a three-hour processing time was established to allow the separation of the material from the collector. The obtained material was characterized by observations on scanning electron microscopy, Fourier transform infrared spectroscopy and thermal analysis; contact angle measurement was performed to evaluate wettability properties, and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated using the Kirby–Bauer test. The obtained fibers that form the bi-layer scaffold present diameters from 100 to 300 nm. The scaffold presents chemical composition, thermal stability, wettability characteristics and antibacterial activity that fulfill the proposal from this study, based on obtaining a scaffold that could be used as a drug delivery vehicle and a wound dressing material. Molecular Diversity Preservation International 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23324/1/23324.pdf http://eprints.uanl.mx/23324/1.haspreviewThumbnailVersion/23324.pdf López Calderón, Héctor Daniel y Avilés Arnaut, Hamlet y Galán Wong, Luis Jesús y Almaguer Cantú, Verónica y Laguna Camacho, J. R. y Calderón Ramón, C. y Escalante Martínez, J. E. y Arévalo Niño, Katiushka (2020) Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing. Polymers, 12 (10). pp. 1-12. ISSN 2073-4360 http://doi.org/10.3390/polym12102311 doi:10.3390/polym12102311 |
| spellingShingle | TP Tecnología Química López Calderón, Héctor Daniel Avilés Arnaut, Hamlet Galán Wong, Luis Jesús Almaguer Cantú, Verónica Laguna Camacho, J. R. Calderón Ramón, C. Escalante Martínez, J. E. Arévalo Niño, Katiushka Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing |
| title_full | Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing |
| title_fullStr | Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing |
| title_full_unstemmed | Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing |
| title_short | Electrospun Polyvinylpyrrolidone-Gelatin and Cellulose Acetate Bi-Layer Scaffold Loaded with Gentamicin as Possible Wound Dressing |
| title_sort | electrospun polyvinylpyrrolidone gelatin and cellulose acetate bi layer scaffold loaded with gentamicin as possible wound dressing |
| topic | TP Tecnología Química |
| url | http://eprints.uanl.mx/23324/1/23324.pdf |
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