Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis
Over the last years, invasive infections caused by filamentous fungi have constituted a serious threat to public health worldwide. Aspergillus, Coccidioides, Mucorales (the most common filamentous fungi), and Candida auris (non-filamentous fungus) can cause infections in humans. They are able to cau...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
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Molecular Diversity Preservation International
2021
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/23321/1/23321.pdf |
| _version_ | 1824416840446640128 |
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| author | León Buitimea, Angel Garza Cervantes, Javier Alberto Gallegos Alvarado, Diana Y. Osorio Concepción, Macario Morones Ramírez, José Rubén |
| author_facet | León Buitimea, Angel Garza Cervantes, Javier Alberto Gallegos Alvarado, Diana Y. Osorio Concepción, Macario Morones Ramírez, José Rubén |
| author_sort | León Buitimea, Angel |
| collection | Repositorio Institucional |
| description | Over the last years, invasive infections caused by filamentous fungi have constituted a serious threat to public health worldwide. Aspergillus, Coccidioides, Mucorales (the most common filamentous fungi), and Candida auris (non-filamentous fungus) can cause infections in humans. They are able to cause critical life-threatening illnesses in immunosuppressed individuals, patients with HIV/AIDS, uncontrolled diabetes, hematological diseases, transplantation, and chemotherapy. In this review, we describe the available nanoformulations (both metallic and polymers-based nanoparticles) developed to increase efficacy and reduce the number of adverse effects after the administration of conventional antifungals. To treat aspergillosis and infections caused by Candida, multiple strategies have been used to develop new therapeutic alternatives, such as incorporating coating materials, complexes synthesized by green chemistry, or coupled with polymers. However, the therapeutic options for coccidioidomycosis and mucormycosis are limited; most of them are in the early stages of development. Therefore, more research needs to be performed to develop new therapeutic alternatives that contribute to the progress of this field. |
| format | Article |
| id | eprints-23321 |
| institution | UANL |
| language | English |
| publishDate | 2021 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-233212024-03-04T17:56:06Z http://eprints.uanl.mx/23321/ Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis León Buitimea, Angel Garza Cervantes, Javier Alberto Gallegos Alvarado, Diana Y. Osorio Concepción, Macario Morones Ramírez, José Rubén QR Microbiología Over the last years, invasive infections caused by filamentous fungi have constituted a serious threat to public health worldwide. Aspergillus, Coccidioides, Mucorales (the most common filamentous fungi), and Candida auris (non-filamentous fungus) can cause infections in humans. They are able to cause critical life-threatening illnesses in immunosuppressed individuals, patients with HIV/AIDS, uncontrolled diabetes, hematological diseases, transplantation, and chemotherapy. In this review, we describe the available nanoformulations (both metallic and polymers-based nanoparticles) developed to increase efficacy and reduce the number of adverse effects after the administration of conventional antifungals. To treat aspergillosis and infections caused by Candida, multiple strategies have been used to develop new therapeutic alternatives, such as incorporating coating materials, complexes synthesized by green chemistry, or coupled with polymers. However, the therapeutic options for coccidioidomycosis and mucormycosis are limited; most of them are in the early stages of development. Therefore, more research needs to be performed to develop new therapeutic alternatives that contribute to the progress of this field. Molecular Diversity Preservation International 2021 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23321/1/23321.pdf http://eprints.uanl.mx/23321/1.haspreviewThumbnailVersion/23321.pdf León Buitimea, Angel y Garza Cervantes, Javier Alberto y Gallegos Alvarado, Diana Y. y Osorio Concepción, Macario y Morones Ramírez, José Rubén (2021) Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis. Pathogens, 10. pp. 1-22. ISSN 2076-0817 http://doi.org/10.3390/pathogens10101303 doi:10.3390/pathogens10101303 |
| spellingShingle | QR Microbiología León Buitimea, Angel Garza Cervantes, Javier Alberto Gallegos Alvarado, Diana Y. Osorio Concepción, Macario Morones Ramírez, José Rubén Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis |
| title_full | Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis |
| title_fullStr | Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis |
| title_full_unstemmed | Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis |
| title_short | Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis |
| title_sort | nanomaterial based antifungal therapies to combat fungal diseases aspergillosis coccidioidomycosis mucormycosis and candidiasis |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/23321/1/23321.pdf |
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