Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid
A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H2O]Cl·3H2O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surro...
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| Format: | Article |
| Language: | English |
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2009
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| Online Access: | http://eprints.uanl.mx/23315/1/23315.pdf |
| _version_ | 1824416837496995840 |
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| author | Bivián Castro, Egla Yareth López, Mercedes G. Pedraza Reyes, Mario Bernès, Sylvain Mendoza Díaz, Guillermo |
| author_facet | Bivián Castro, Egla Yareth López, Mercedes G. Pedraza Reyes, Mario Bernès, Sylvain Mendoza Díaz, Guillermo |
| author_sort | Bivián Castro, Egla Yareth |
| collection | Repositorio Institucional |
| description | A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H2O]Cl·3H2O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen. Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)H2O]Cl·3H2O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis strain. Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. In vivo and in vitro biological activities of the chn complex were compared with the chemical nuclease [Cu(phen)(nal)H2O]NO3·3H2O (cpn) where phen is phenanthroline. |
| format | Article |
| id | eprints-23315 |
| institution | UANL |
| language | English |
| publishDate | 2009 |
| record_format | eprints |
| spelling | eprints-233152022-11-19T23:04:32Z http://eprints.uanl.mx/23315/ Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid Bivián Castro, Egla Yareth López, Mercedes G. Pedraza Reyes, Mario Bernès, Sylvain Mendoza Díaz, Guillermo QD Química A mixed copper complex with deprotonated nalidixic acid (nal) and histamine (hsm) was synthesized and characterized by FTIR, UV-Vis, elemental analysis, and conductivity. The crystal structure of [Cu(hsm)(nal)H2O]Cl·3H2O (chn) showed a pentacoordinated cooper(II) in a square pyramidal geometry surrounded by two N atoms from hsm, two O atoms from the quinolone, and one apical water oxygen. Alteration of bacterial DNA structure and/or associated functions in vivo by [Cu(hsm)(nal)H2O]Cl·3H2O was demonstrated by the induction of a recA-lacZ fusion integrated at the amyE locus of a recombinant Bacillus subtilis strain. Results from circular dichroism and denaturation of calf thymus DNA (CT-DNA) suggested that increased amounts of copper complex were able to stabilize the double helix of DNA in vitro mainly by formation of hydrogen bonds between chn and the sugars of DNA minor groove. In vivo and in vitro biological activities of the chn complex were compared with the chemical nuclease [Cu(phen)(nal)H2O]NO3·3H2O (cpn) where phen is phenanthroline. 2009 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/23315/1/23315.pdf http://eprints.uanl.mx/23315/1.haspreviewThumbnailVersion/23315.pdf Bivián Castro, Egla Yareth y López, Mercedes G. y Pedraza Reyes, Mario y Bernès, Sylvain y Mendoza Díaz, Guillermo (2009) Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid. Bioinorganic chemistry and applications, 2009. pp. 1-8. ISSN 1565-3633 http://doi.org/10.1155/2009/603651 doi:10.1155/2009/603651 |
| spellingShingle | QD Química Bivián Castro, Egla Yareth López, Mercedes G. Pedraza Reyes, Mario Bernès, Sylvain Mendoza Díaz, Guillermo Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
| title_full | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
| title_fullStr | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
| title_full_unstemmed | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
| title_short | Synthesis, Characterization, and Biological Activity Studies of Copper(II) Mixed Compound with Histamine and Nalidixic Acid |
| title_sort | synthesis characterization and biological activity studies of copper ii mixed compound with histamine and nalidixic acid |
| topic | QD Química |
| url | http://eprints.uanl.mx/23315/1/23315.pdf |
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