Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy?
Objectives: We report the successful treatment of a bloodstream infection caused by Klebsiella pneumoniae harbouring NDM-1 using aztreonam-ceftazidime-avibactam in a neutropenic patient in whom colistin and meropenem therapy had previously failed. Methods: A clinical isolate was evaluated to dete...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/22453/1/22453.pdf |
| _version_ | 1824416532168441856 |
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| author | Bocanegra Ibarias, Paola Camacho Ortiz, Adrián Garza González, Elvira Flores Treviño, Samantha Maribel Kim, Hyojin Pérez Alba, Eduardo |
| author_facet | Bocanegra Ibarias, Paola Camacho Ortiz, Adrián Garza González, Elvira Flores Treviño, Samantha Maribel Kim, Hyojin Pérez Alba, Eduardo |
| author_sort | Bocanegra Ibarias, Paola |
| collection | Repositorio Institucional |
| description | Objectives: We report the successful treatment of a bloodstream infection caused by Klebsiella pneumoniae harbouring NDM-1 using aztreonam-ceftazidime-avibactam in a neutropenic patient in whom colistin and meropenem therapy had previously failed.
Methods: A clinical isolate was evaluated to determine the presence of NDM, TEM, SHV, CTX, and CMY, and the killing kinetics of aztreonam (ATM; 4 mg/mL), aztreonam-avibactam (ATM-AVI; 4/4 mg/mL), and colistin (2 and 4 mg/mL) were tested.
Results: ATM-AVI showed in vitro activity against the Klebsiella pneumoniae harbouring NDM-1, whereas
colistin allowed re-growth.
Conclusions: This report supports reconsideration of use of colistin for treatment of infections caused by
K. pneumoniae harbouring NDM. CZA/ATM use should be kept in mind as a treatment option, perhaps earlier than colistin. |
| format | Article |
| id | eprints-22453 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | eprints |
| spelling | eprints-224532021-11-11T21:53:11Z http://eprints.uanl.mx/22453/ Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? Bocanegra Ibarias, Paola Camacho Ortiz, Adrián Garza González, Elvira Flores Treviño, Samantha Maribel Kim, Hyojin Pérez Alba, Eduardo QR Microbiología Objectives: We report the successful treatment of a bloodstream infection caused by Klebsiella pneumoniae harbouring NDM-1 using aztreonam-ceftazidime-avibactam in a neutropenic patient in whom colistin and meropenem therapy had previously failed. Methods: A clinical isolate was evaluated to determine the presence of NDM, TEM, SHV, CTX, and CMY, and the killing kinetics of aztreonam (ATM; 4 mg/mL), aztreonam-avibactam (ATM-AVI; 4/4 mg/mL), and colistin (2 and 4 mg/mL) were tested. Results: ATM-AVI showed in vitro activity against the Klebsiella pneumoniae harbouring NDM-1, whereas colistin allowed re-growth. Conclusions: This report supports reconsideration of use of colistin for treatment of infections caused by K. pneumoniae harbouring NDM. CZA/ATM use should be kept in mind as a treatment option, perhaps earlier than colistin. Elsevier 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/22453/1/22453.pdf http://eprints.uanl.mx/22453/1.haspreviewThumbnailVersion/22453.pdf Bocanegra Ibarias, Paola y Camacho Ortiz, Adrián y Garza González, Elvira y Flores Treviño, Samantha Maribel y Kim, Hyojin y Pérez Alba, Eduardo (2020) Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? Journal of Global Antimicrobial Resistance, 23. pp. 417-419. ISSN 22137165 http://doi.org/10.1016/j.jgar.2020.10.019 doi:10.1016/j.jgar.2020.10.019 |
| spellingShingle | QR Microbiología Bocanegra Ibarias, Paola Camacho Ortiz, Adrián Garza González, Elvira Flores Treviño, Samantha Maribel Kim, Hyojin Pérez Alba, Eduardo Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? |
| title_full | Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? |
| title_fullStr | Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? |
| title_full_unstemmed | Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? |
| title_short | Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? |
| title_sort | aztreonam plus ceftazidime avibactam as treatment of ndm 1 producing klebsiella pneumoniae bacteraemia in a neutropenic patient last resort therapy |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/22453/1/22453.pdf |
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