Origin of personalized medicine in pioneering, passionate, genomic research
Personalized medicine, one of the main promises of the Human Genome Project (HGP) that began three decades ago, is now a new therapeutic paradigm. With its arrival the era of developing drugs to suit all patients, yet often having to withdraw a promising new one because a minority of patients was...
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2020
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| Acceso en línea: | http://eprints.uanl.mx/20119/1/1-s2.0-S0888754319300692-main.pdf |
| _version_ | 1824415756015632384 |
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| author | Barrera Saldaña, Hugo Alberto |
| author_facet | Barrera Saldaña, Hugo Alberto |
| author_sort | Barrera Saldaña, Hugo Alberto |
| collection | Repositorio Institucional |
| description | Personalized medicine, one of the main promises of the Human Genome Project (HGP) that began three decades
ago, is now a new therapeutic paradigm. With its arrival the era of developing drugs to suit all patients, yet often
having to withdraw a promising new one because a minority of patients was at risk, even though it had proved
valuable for the majority was consigned to history as were trial-and-error strategies being the predominant
means of tailoring therapy. But how did it originate and the earliest examples emerge? Is it true that the first
personalized diagnostic test was the companion test for Herceptin®? This account of a remarkable journey from
genomic and translational research to therapeutic and diagnostic innovations, describes how sequencing the
human growth hormone (hGH) locus provided proof of principle for HGP-inspired personalized medicine.
Sequencing this locus and the resultant biomanufacture of HGH and the development of a test capable of detecting which patients would benefit from its administration helped silence the skeptics who questioned the
validity of such an approach. The associated companion diagnostic was created four years before the invention
of the HercepTest® (registered as the first companion diagnostics ever developed). By cultivating genomic research with passion and pursuing its applications, we and many others contributed to the emergence of a new
diagnostics industry, the discovery of better actionable gene-targets and to a revitalized pharmaceutical industry
capable of developing safer and more effective therapies. In combination, these developments are beginning to
fulfill the promise of the HGP, offering each patient the opportunity to adopt the right treatment at the correct
dosage in an opportune manner. |
| format | Article |
| id | eprints-20119 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| record_format | eprints |
| spelling | eprints-201192024-12-09T17:43:20Z http://eprints.uanl.mx/20119/ Origin of personalized medicine in pioneering, passionate, genomic research Barrera Saldaña, Hugo Alberto QH Historia Natural, Biología Personalized medicine, one of the main promises of the Human Genome Project (HGP) that began three decades ago, is now a new therapeutic paradigm. With its arrival the era of developing drugs to suit all patients, yet often having to withdraw a promising new one because a minority of patients was at risk, even though it had proved valuable for the majority was consigned to history as were trial-and-error strategies being the predominant means of tailoring therapy. But how did it originate and the earliest examples emerge? Is it true that the first personalized diagnostic test was the companion test for Herceptin®? This account of a remarkable journey from genomic and translational research to therapeutic and diagnostic innovations, describes how sequencing the human growth hormone (hGH) locus provided proof of principle for HGP-inspired personalized medicine. Sequencing this locus and the resultant biomanufacture of HGH and the development of a test capable of detecting which patients would benefit from its administration helped silence the skeptics who questioned the validity of such an approach. The associated companion diagnostic was created four years before the invention of the HercepTest® (registered as the first companion diagnostics ever developed). By cultivating genomic research with passion and pursuing its applications, we and many others contributed to the emergence of a new diagnostics industry, the discovery of better actionable gene-targets and to a revitalized pharmaceutical industry capable of developing safer and more effective therapies. In combination, these developments are beginning to fulfill the promise of the HGP, offering each patient the opportunity to adopt the right treatment at the correct dosage in an opportune manner. 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/20119/1/1-s2.0-S0888754319300692-main.pdf http://eprints.uanl.mx/20119/1.haspreviewThumbnailVersion/1-s2.0-S0888754319300692-main.pdf Barrera Saldaña, Hugo Alberto (2020) Origin of personalized medicine in pioneering, passionate, genomic research. Genomics, 112 (1). pp. 721-728. ISSN 0888-7543 http://doi.org/10.1016/J.YGENO.2019.05.006 doi:10.1016/J.YGENO.2019.05.006 |
| spellingShingle | QH Historia Natural, Biología Barrera Saldaña, Hugo Alberto Origin of personalized medicine in pioneering, passionate, genomic research |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Origin of personalized medicine in pioneering, passionate, genomic research |
| title_full | Origin of personalized medicine in pioneering, passionate, genomic research |
| title_fullStr | Origin of personalized medicine in pioneering, passionate, genomic research |
| title_full_unstemmed | Origin of personalized medicine in pioneering, passionate, genomic research |
| title_short | Origin of personalized medicine in pioneering, passionate, genomic research |
| title_sort | origin of personalized medicine in pioneering passionate genomic research |
| topic | QH Historia Natural, Biología |
| url | http://eprints.uanl.mx/20119/1/1-s2.0-S0888754319300692-main.pdf |
| work_keys_str_mv | AT barrerasaldanahugoalberto originofpersonalizedmedicineinpioneeringpassionategenomicresearch |