Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival
Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children representsa high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanicpopulations, in which it is a rare malignancy. We report the characteristics and results oftreatment for childhood T-c...
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| Formato: | Artículo |
| Lenguaje: | inglés |
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2019
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| Acceso en línea: | http://eprints.uanl.mx/20117/1/1-s2.0-S2531137919301646-main.pdf |
| _version_ | 1824415755114905600 |
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| author | Jaime Pérez, José Carlos Hernández de los Santos, José Antonio Gómez Almaguer, David |
| author_facet | Jaime Pérez, José Carlos Hernández de los Santos, José Antonio Gómez Almaguer, David |
| author_sort | Jaime Pérez, José Carlos |
| collection | Repositorio Institucional |
| description | Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children representsa high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanicpopulations, in which it is a rare malignancy. We report the characteristics and results oftreatment for childhood T-cell ALL in children over 14 years at a Latin American referencecenter.Material and methods: From January 2005 to December 2018, there occurred the analysisof twenty patients ≤ 16 years of age from a low-income open population diagnosed ata university hospital in Northeast Mexico. Clinical and laboratory characteristics, treat-ment regimens and outcomes were assessed by scrutinizing clinical records and electronicdatabases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method.Results: There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p = .074), themedian age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children,with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival(OS) was 44.3 % (95 % CI 41.96–46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32–24.51)vs. 53.1 % (95 % CI 50.30–55.82), (p = .035) in boys; there was no sex difference in the event-freesurvival (EFS) (p = .215). The survival was significantly higher after 2010 (p = .034).Conclusion: The T-cell ALL was more frequent in boys, had a higher mortality in girls and thesurvival has increased over the last decade with improved chemotherapy and supportivecare. |
| format | Article |
| id | eprints-20117 |
| institution | UANL |
| language | English |
| publishDate | 2019 |
| record_format | eprints |
| spelling | eprints-201172020-10-16T15:04:06Z http://eprints.uanl.mx/20117/ Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival Jaime Pérez, José Carlos Hernández de los Santos, José Antonio Gómez Almaguer, David RC Medicina Interna, Psiquiatría, Neurología Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children representsa high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanicpopulations, in which it is a rare malignancy. We report the characteristics and results oftreatment for childhood T-cell ALL in children over 14 years at a Latin American referencecenter.Material and methods: From January 2005 to December 2018, there occurred the analysisof twenty patients ≤ 16 years of age from a low-income open population diagnosed ata university hospital in Northeast Mexico. Clinical and laboratory characteristics, treat-ment regimens and outcomes were assessed by scrutinizing clinical records and electronicdatabases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method.Results: There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p = .074), themedian age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children,with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival(OS) was 44.3 % (95 % CI 41.96–46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32–24.51)vs. 53.1 % (95 % CI 50.30–55.82), (p = .035) in boys; there was no sex difference in the event-freesurvival (EFS) (p = .215). The survival was significantly higher after 2010 (p = .034).Conclusion: The T-cell ALL was more frequent in boys, had a higher mortality in girls and thesurvival has increased over the last decade with improved chemotherapy and supportivecare. 2019 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/20117/1/1-s2.0-S2531137919301646-main.pdf http://eprints.uanl.mx/20117/1.haspreviewThumbnailVersion/1-s2.0-S2531137919301646-main.pdf Jaime Pérez, José Carlos y Hernández de los Santos, José Antonio y Gómez Almaguer, David (2019) Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival. Hematology, Transfusion and Cell Therapy. ISSN 2531-1379 http://doi.org/10.1016/j.htct.2019.09.005 doi:10.1016/j.htct.2019.09.005 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Jaime Pérez, José Carlos Hernández de los Santos, José Antonio Gómez Almaguer, David Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
| title_full | Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
| title_fullStr | Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
| title_full_unstemmed | Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
| title_short | Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
| title_sort | childhood t cell acute lymphoblastic leukemia in a single latin american center impact of improved treatment scheme and support therapy on survival |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/20117/1/1-s2.0-S2531137919301646-main.pdf |
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