Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis
Objectives: Linezolid is a synthetic oxazolidinone antibiotic frequently used to treat vancomycin-resistant enterococcal infections. Vancomycin-susceptible Enterococcus faecalis can develop resistance to linezolid in environments with excessive linezolid use. The aim of this study was to define ri...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/20099/1/1-s2.0-S2213716520300114-main.pdf |
| _version_ | 1824415748891607040 |
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| author | Rodríguez Noriega, Eduardo Hernández Morfin, Natalia Garza González, Elvira Bocanegra Ibarias, Paola Flores Treviño, Samantha Maribel Esparza Ahumada, Sergio Gonzalez Diaz, Esteban E. Pérez Gómez, Héctor Raúl Mendoza Mujica, Christian León Garnica, Gerardo Morfín Otero, Rayo |
| author_facet | Rodríguez Noriega, Eduardo Hernández Morfin, Natalia Garza González, Elvira Bocanegra Ibarias, Paola Flores Treviño, Samantha Maribel Esparza Ahumada, Sergio Gonzalez Diaz, Esteban E. Pérez Gómez, Héctor Raúl Mendoza Mujica, Christian León Garnica, Gerardo Morfín Otero, Rayo |
| author_sort | Rodríguez Noriega, Eduardo |
| collection | Repositorio Institucional |
| description | Objectives: Linezolid is a synthetic oxazolidinone antibiotic frequently used to treat vancomycin-resistant
enterococcal infections. Vancomycin-susceptible Enterococcus faecalis can develop resistance to linezolid
in environments with excessive linezolid use. The aim of this study was to define risk factors and outcome
associated with the acquisition of linezolid-resistant E. faecalis (LREfs).
Methods: A retrospective case–control study was designed including patients hospitalised from January
2014 to October 2017 at Hospital Civil de Guadalajara ‘Fray Antonio Alcalde’ in Guadalajara, Mexico. A
total of 50 patients culture-positive for LREfs and 100 control patients hospitalised in the same room and
time as the cases were included. Clinical and demographic data were collected and analysed.
Results: Risk factors for the presence of LREfs included prior linezolid use [odds ratio (OR) = 6.74], prior
clindamycin use (OR = 6.72) and previous surgery (OR = 5.79). The mortality rate was 18% for LREfs cases
versus 9% for controls.
Conclusion: LREfs has emerged and spread in our hospital, an environment in which linezolid use is
considerable. Risk factors for LREfs are prior antibiotic use, including linezolid, and previous surgery. |
| format | Article |
| id | eprints-20099 |
| institution | UANL |
| language | English |
| publishDate | 2020 |
| record_format | eprints |
| spelling | eprints-200992020-10-15T12:33:44Z http://eprints.uanl.mx/20099/ Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis Rodríguez Noriega, Eduardo Hernández Morfin, Natalia Garza González, Elvira Bocanegra Ibarias, Paola Flores Treviño, Samantha Maribel Esparza Ahumada, Sergio Gonzalez Diaz, Esteban E. Pérez Gómez, Héctor Raúl Mendoza Mujica, Christian León Garnica, Gerardo Morfín Otero, Rayo QR Microbiología Objectives: Linezolid is a synthetic oxazolidinone antibiotic frequently used to treat vancomycin-resistant enterococcal infections. Vancomycin-susceptible Enterococcus faecalis can develop resistance to linezolid in environments with excessive linezolid use. The aim of this study was to define risk factors and outcome associated with the acquisition of linezolid-resistant E. faecalis (LREfs). Methods: A retrospective case–control study was designed including patients hospitalised from January 2014 to October 2017 at Hospital Civil de Guadalajara ‘Fray Antonio Alcalde’ in Guadalajara, Mexico. A total of 50 patients culture-positive for LREfs and 100 control patients hospitalised in the same room and time as the cases were included. Clinical and demographic data were collected and analysed. Results: Risk factors for the presence of LREfs included prior linezolid use [odds ratio (OR) = 6.74], prior clindamycin use (OR = 6.72) and previous surgery (OR = 5.79). The mortality rate was 18% for LREfs cases versus 9% for controls. Conclusion: LREfs has emerged and spread in our hospital, an environment in which linezolid use is considerable. Risk factors for LREfs are prior antibiotic use, including linezolid, and previous surgery. 2020 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/20099/1/1-s2.0-S2213716520300114-main.pdf http://eprints.uanl.mx/20099/1.haspreviewThumbnailVersion/1-s2.0-S2213716520300114-main.pdf Rodríguez Noriega, Eduardo y Hernández Morfin, Natalia y Garza González, Elvira y Bocanegra Ibarias, Paola y Flores Treviño, Samantha Maribel y Esparza Ahumada, Sergio y Gonzalez Diaz, Esteban E. y Pérez Gómez, Héctor Raúl y Mendoza Mujica, Christian y León Garnica, Gerardo y Morfín Otero, Rayo (2020) Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis. Journal of Global Antimicrobial Resistance, 21. pp. 405-409. ISSN 2213-7165 http://doi.org/10.1016/J.JGAR.2020.01.010 doi:10.1016/J.JGAR.2020.01.010 |
| spellingShingle | QR Microbiología Rodríguez Noriega, Eduardo Hernández Morfin, Natalia Garza González, Elvira Bocanegra Ibarias, Paola Flores Treviño, Samantha Maribel Esparza Ahumada, Sergio Gonzalez Diaz, Esteban E. Pérez Gómez, Héctor Raúl Mendoza Mujica, Christian León Garnica, Gerardo Morfín Otero, Rayo Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis |
| title_full | Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis |
| title_fullStr | Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis |
| title_full_unstemmed | Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis |
| title_short | Risk factors and outcome associated with the acquisition of linezolid-resistant Enterococcus faecalis |
| title_sort | risk factors and outcome associated with the acquisition of linezolid resistant enterococcus faecalis |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/20099/1/1-s2.0-S2213716520300114-main.pdf |
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