Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis
Background: Breast cancer is one of the most common malignancies affecting women. Recent investigations have revealed a major role of ion channels in cancer. The transient receptor potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel with important roles in cell migration and...
| Autores principales: | , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Hospital Infantil de México
2016
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/20041/1/1-s2.0-S1665114616301009-main.pdf |
| _version_ | 1824415730739707904 |
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| author | Sumoza Toledo, Adriana Espinoza Gabriel, Mario Iván Montiel Condado, Dvorak |
| author_facet | Sumoza Toledo, Adriana Espinoza Gabriel, Mario Iván Montiel Condado, Dvorak |
| author_sort | Sumoza Toledo, Adriana |
| collection | Repositorio Institucional |
| description | Background: Breast cancer is one of the most common malignancies affecting women. Recent
investigations have revealed a major role of ion channels in cancer. The transient receptor
potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel with important
roles in cell migration and cell death in immune cells and tumor cells.
Methods: In this study, we investigated the prognostic value of TRPM2 channel in breast cancer,
analyzing public databases compiled in OncomineTM (Thermo Fisher, Ann Arbor, MI) and online
Kaplan-Meier Plotter platforms.
Results: The results revealed that TRPM2 mRNA overexpression is significant in situ and invasive
breast carcinoma compared to normal breast tissue. Furthermore, multi-gene validation using
OncomineTM showed that this channel is coexpressed with proteins related to cellular migration,
transformation, and apoptosis. On the other hand, Kaplan-Meier analysis exhibited that low
expression of TRPM2 could be used to predict poor outcome in ER- and HER2+ breast carcinoma
patients.
Conclusions: TRPM2 is a promising biomarker for aggressiveness of breast cancer, and a potential
target for the development of new therapies. |
| format | Article |
| id | eprints-20041 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| publisher | Hospital Infantil de México |
| record_format | eprints |
| spelling | eprints-200412020-10-13T00:09:33Z http://eprints.uanl.mx/20041/ Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis Sumoza Toledo, Adriana Espinoza Gabriel, Mario Iván Montiel Condado, Dvorak QH Historia Natural, Biología Background: Breast cancer is one of the most common malignancies affecting women. Recent investigations have revealed a major role of ion channels in cancer. The transient receptor potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel with important roles in cell migration and cell death in immune cells and tumor cells. Methods: In this study, we investigated the prognostic value of TRPM2 channel in breast cancer, analyzing public databases compiled in OncomineTM (Thermo Fisher, Ann Arbor, MI) and online Kaplan-Meier Plotter platforms. Results: The results revealed that TRPM2 mRNA overexpression is significant in situ and invasive breast carcinoma compared to normal breast tissue. Furthermore, multi-gene validation using OncomineTM showed that this channel is coexpressed with proteins related to cellular migration, transformation, and apoptosis. On the other hand, Kaplan-Meier analysis exhibited that low expression of TRPM2 could be used to predict poor outcome in ER- and HER2+ breast carcinoma patients. Conclusions: TRPM2 is a promising biomarker for aggressiveness of breast cancer, and a potential target for the development of new therapies. Hospital Infantil de México 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/20041/1/1-s2.0-S1665114616301009-main.pdf http://eprints.uanl.mx/20041/1.haspreviewThumbnailVersion/1-s2.0-S1665114616301009-main.pdf Sumoza Toledo, Adriana y Espinoza Gabriel, Mario Iván y Montiel Condado, Dvorak (2016) Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis. Boletín médico del Hospital Infantil de México, 73 (6). pp. 397-404. ISSN 1665-1146 http://doi.org/10.1016/j.bmhimx.2016.10.001 doi:10.1016/j.bmhimx.2016.10.001 |
| spellingShingle | QH Historia Natural, Biología Sumoza Toledo, Adriana Espinoza Gabriel, Mario Iván Montiel Condado, Dvorak Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis |
| title_full | Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis |
| title_fullStr | Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis |
| title_full_unstemmed | Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis |
| title_short | Evaluation of the TRPM2 channel as a biomarker in breast cancer using public databases analysis |
| title_sort | evaluation of the trpm2 channel as a biomarker in breast cancer using public databases analysis |
| topic | QH Historia Natural, Biología |
| url | http://eprints.uanl.mx/20041/1/1-s2.0-S1665114616301009-main.pdf |
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