| Summary: | Background: Breast cancer is one of the most common malignancies affecting women. Recent
investigations have revealed a major role of ion channels in cancer. The transient receptor
potential melastatin-2 (TRPM2) is a plasma membrane and lysosomal channel with important
roles in cell migration and cell death in immune cells and tumor cells.
Methods: In this study, we investigated the prognostic value of TRPM2 channel in breast cancer,
analyzing public databases compiled in OncomineTM (Thermo Fisher, Ann Arbor, MI) and online
Kaplan-Meier Plotter platforms.
Results: The results revealed that TRPM2 mRNA overexpression is significant in situ and invasive
breast carcinoma compared to normal breast tissue. Furthermore, multi-gene validation using
OncomineTM showed that this channel is coexpressed with proteins related to cellular migration,
transformation, and apoptosis. On the other hand, Kaplan-Meier analysis exhibited that low
expression of TRPM2 could be used to predict poor outcome in ER- and HER2+ breast carcinoma
patients.
Conclusions: TRPM2 is a promising biomarker for aggressiveness of breast cancer, and a potential
target for the development of new therapies.
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