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Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model

Background Non-human primate (NHP) diabetic models using chemical ablation of b-cells with STZ have been achieved by several research groups. Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and mortality. Methods We implemented a comprehensive t...

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Detalles Bibliográficos
Autores principales: Frost, Patrice A., Chen, Shuyuan, Mezzles, Marguerite J., Voruganti, Venkata Saroja, Nava González, Edna Judith, Arriaga Cazares, Hector E., Freed, Katy A., Comuzzie, Anthony G., DeFronzo, Ralph A., Kent, Jack W., Grayburn, Paul A., Bastarrachea, Raúl A.
Formato: Artículo
Lenguaje:inglés
Publicado: 2015
Materias:
RA Aspectos Públicos de la Medicina
Acceso en línea:http://eprints.uanl.mx/18861/1/3.pdf

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