Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model
Background Non-human primate (NHP) diabetic models using chemical ablation of b-cells with STZ have been achieved by several research groups. Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and mortality. Methods We implemented a comprehensive t...
Main Authors: | Frost, Patrice A., Chen, Shuyuan, Mezzles, Marguerite J., Voruganti, Venkata Saroja, Nava González, Edna Judith, Arriaga Cazares, Hector E., Freed, Katy A., Comuzzie, Anthony G., DeFronzo, Ralph A., Kent, Jack W., Grayburn, Paul A., Bastarrachea, Raúl A. |
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Format: | Article |
Language: | English |
Published: |
2015
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Subjects: | |
Online Access: | http://eprints.uanl.mx/18861/1/3.pdf |
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