Successful pharmaceutical-grade streptozotocin (STZ)-induced hyperglycemia in a conscious tethered baboon (Papio hamadryas) model

Background Non-human primate (NHP) diabetic models using chemical ablation of b-cells with STZ have been achieved by several research groups. Chemotherapeutic STZ could lead to serious adverse events including nephrotoxicity, hepatotoxicity, and mortality. Methods We implemented a comprehensive t...

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Bibliographic Details

Main Authors:	Frost, Patrice A., Chen, Shuyuan, Mezzles, Marguerite J., Voruganti, Venkata Saroja, Nava González, Edna Judith, Arriaga Cazares, Hector E., Freed, Katy A., Comuzzie, Anthony G., DeFronzo, Ralph A., Kent, Jack W., Grayburn, Paul A., Bastarrachea, Raúl A.
Format:	Article
Language:	English
Published:	2015
Subjects:	RA Aspectos Públicos de la Medicina
Online Access:	http://eprints.uanl.mx/18861/1/3.pdf