Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design

plasmid cDNA contructs encoding a gene cocktail with BMP7/ PRDM16/PPARGC1A incorporated within microbubbles and intravenously delivered into their left thigh. Controls received UTMD with plasmids driving a DsRed reporter gene. An ultrasound transducer was directed to the thigh to disrupt the mic...

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Bibliographic Details

Main Authors:	Bastarrachea, Raúl A., Chen, Jiaxi, Kent, Jack W., Nava González, Edna Judith, Rodríguez Ayala, Ernesto, Daadi, Marcel M., Jorge, Barbara, Laviada Molina, Hugo A., Comuzzie, Anthony G., Chen, Shuyuan, Grayburn, Paul A.
Format:	Article
Language:	English
Published:	2017
Subjects:	RA Aspectos Públicos de la Medicina
Online Access:	http://eprints.uanl.mx/18859/1/4.pdf