Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design
plasmid cDNA contructs encoding a gene cocktail with BMP7/ PRDM16/PPARGC1A incorporated within microbubbles and intravenously delivered into their left thigh. Controls received UTMD with plasmids driving a DsRed reporter gene. An ultrasound transducer was directed to the thigh to disrupt the mic...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/18859/1/4.pdf |
| _version_ | 1824415368115912704 |
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| author | Bastarrachea, Raúl A. Chen, Jiaxi Kent, Jack W. Nava González, Edna Judith Rodríguez Ayala, Ernesto Daadi, Marcel M. Jorge, Barbara Laviada Molina, Hugo A. Comuzzie, Anthony G. Chen, Shuyuan Grayburn, Paul A. |
| author_facet | Bastarrachea, Raúl A. Chen, Jiaxi Kent, Jack W. Nava González, Edna Judith Rodríguez Ayala, Ernesto Daadi, Marcel M. Jorge, Barbara Laviada Molina, Hugo A. Comuzzie, Anthony G. Chen, Shuyuan Grayburn, Paul A. |
| author_sort | Bastarrachea, Raúl A. |
| collection | Repositorio Institucional |
| description | plasmid cDNA contructs encoding a gene cocktail with BMP7/
PRDM16/PPARGC1A incorporated within microbubbles and
intravenously delivered into their left thigh. Controls received
UTMD with plasmids driving a DsRed reporter gene. An ultrasound transducer was directed to the thigh to disrupt the
microbubbles within the microcirculation. Blood samples were
drawn at baseline, and after treatment to measure glucose,
insulin, and free fatty acids levels |
| format | Article |
| id | eprints-18859 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-188592020-03-05T20:31:18Z http://eprints.uanl.mx/18859/ Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design Bastarrachea, Raúl A. Chen, Jiaxi Kent, Jack W. Nava González, Edna Judith Rodríguez Ayala, Ernesto Daadi, Marcel M. Jorge, Barbara Laviada Molina, Hugo A. Comuzzie, Anthony G. Chen, Shuyuan Grayburn, Paul A. RA Aspectos Públicos de la Medicina plasmid cDNA contructs encoding a gene cocktail with BMP7/ PRDM16/PPARGC1A incorporated within microbubbles and intravenously delivered into their left thigh. Controls received UTMD with plasmids driving a DsRed reporter gene. An ultrasound transducer was directed to the thigh to disrupt the microbubbles within the microcirculation. Blood samples were drawn at baseline, and after treatment to measure glucose, insulin, and free fatty acids levels 2017-07-31 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18859/1/4.pdf http://eprints.uanl.mx/18859/1.haspreviewThumbnailVersion/4.pdf Bastarrachea, Raúl A. y Chen, Jiaxi y Kent, Jack W. y Nava González, Edna Judith y Rodríguez Ayala, Ernesto y Daadi, Marcel M. y Jorge, Barbara y Laviada Molina, Hugo A. y Comuzzie, Anthony G. y Chen, Shuyuan y Grayburn, Paul A. (2017) Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design. IUBMB Life, 69 (9). pp. 745-755. ISSN 15216543 http://doi.org/10.1002/iub.1658 doi:10.1002/iub.1658 |
| spellingShingle | RA Aspectos Públicos de la Medicina Bastarrachea, Raúl A. Chen, Jiaxi Kent, Jack W. Nava González, Edna Judith Rodríguez Ayala, Ernesto Daadi, Marcel M. Jorge, Barbara Laviada Molina, Hugo A. Comuzzie, Anthony G. Chen, Shuyuan Grayburn, Paul A. Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
| title_full | Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
| title_fullStr | Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
| title_full_unstemmed | Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
| title_short | Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design |
| title_sort | engineering brown fat into skeletal muscle using ultrasound targeted microbubble destruction gene delivery in obese zucker rats proof of concept design |
| topic | RA Aspectos Públicos de la Medicina |
| url | http://eprints.uanl.mx/18859/1/4.pdf |
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