Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence of the Identification of causal genes for cardiovascular and metabolic traits related to nutrition in mexicans1–3
Whole-transcriptome expression profiling provides novel phenotypes for analysis of complex traits. Gene expression measurements reflect quantitative variation in transcript-specific messenger RNA levels and represent phenotypes lying close to the action of genes. Understanding the genetic basis of...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Oxford Academic
2012
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/18849/1/17.pdf |
| _version_ | 1835349255722631168 |
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| author | Bastarrachea, Raúl A. Gallegos Cabriales, Esther Carlota Nava González, Edna Judith Haack, Karin Saroja Vorunganti, V. Charlesworth, Jac Laviada Molina, Hugo A. Veloz Garza, Rosa A. Cárdenas Villarreal, Velia Margarita Valdovinos Chávez, Salvador H. Gómez Aguilar, Patricia Isolina del Socorro Meléndez, Guillermo López Alvarenga, Juan Carlos H. Góring, Harald H. Cole, Shelley A. Blangero, John Comuzzie, Anthony G. Kent, Jack W. |
| author_facet | Bastarrachea, Raúl A. Gallegos Cabriales, Esther Carlota Nava González, Edna Judith Haack, Karin Saroja Vorunganti, V. Charlesworth, Jac Laviada Molina, Hugo A. Veloz Garza, Rosa A. Cárdenas Villarreal, Velia Margarita Valdovinos Chávez, Salvador H. Gómez Aguilar, Patricia Isolina del Socorro Meléndez, Guillermo López Alvarenga, Juan Carlos H. Góring, Harald H. Cole, Shelley A. Blangero, John Comuzzie, Anthony G. Kent, Jack W. |
| author_sort | Bastarrachea, Raúl A. |
| collection | Repositorio Institucional |
| description | Whole-transcriptome expression profiling provides novel phenotypes for analysis of complex traits. Gene expression measurements reflect
quantitative variation in transcript-specific messenger RNA levels and represent phenotypes lying close to the action of genes. Understanding the
genetic basis of gene expression will provide insight into the processes that connect genotype to clinically significant traits representing a central
tenet of system biology. Synchronous in vivo expression profiles of lymphocytes, muscle, and subcutaneous fat were obtained from healthy Mexican
men. Most genes were expressed at detectable levels in multiple tissues, and RNA levels were correlated between tissue types. A subset of transcripts
with high reliability of expression across tissues (estimated by intraclass correlation coefficients) was enriched for cis-regulated genes, suggesting that
proximal sequence variants may influence expression similarly in different cellular environments. This integrative global gene expression profiling
approach is proving extremely useful for identifying genes and pathways that contribute to complex clinical traits. Clearly, the coincidence of clinical
trait quantitative trait loci and expression quantitative trait loci can help in the prioritization of positional candidate genes. Such data will be crucial
for the formal integration of positional and transcriptomic information characterized as genetical genomics. A |
| format | Article |
| id | eprints-18849 |
| institution | UANL |
| language | English |
| publishDate | 2012 |
| publisher | Oxford Academic |
| record_format | eprints |
| spelling | eprints-188492025-06-17T19:28:19Z http://eprints.uanl.mx/18849/ Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence of the Identification of causal genes for cardiovascular and metabolic traits related to nutrition in mexicans1–3 Bastarrachea, Raúl A. Gallegos Cabriales, Esther Carlota Nava González, Edna Judith Haack, Karin Saroja Vorunganti, V. Charlesworth, Jac Laviada Molina, Hugo A. Veloz Garza, Rosa A. Cárdenas Villarreal, Velia Margarita Valdovinos Chávez, Salvador H. Gómez Aguilar, Patricia Isolina del Socorro Meléndez, Guillermo López Alvarenga, Juan Carlos H. Góring, Harald H. Cole, Shelley A. Blangero, John Comuzzie, Anthony G. Kent, Jack W. R Medicina en General Whole-transcriptome expression profiling provides novel phenotypes for analysis of complex traits. Gene expression measurements reflect quantitative variation in transcript-specific messenger RNA levels and represent phenotypes lying close to the action of genes. Understanding the genetic basis of gene expression will provide insight into the processes that connect genotype to clinically significant traits representing a central tenet of system biology. Synchronous in vivo expression profiles of lymphocytes, muscle, and subcutaneous fat were obtained from healthy Mexican men. Most genes were expressed at detectable levels in multiple tissues, and RNA levels were correlated between tissue types. A subset of transcripts with high reliability of expression across tissues (estimated by intraclass correlation coefficients) was enriched for cis-regulated genes, suggesting that proximal sequence variants may influence expression similarly in different cellular environments. This integrative global gene expression profiling approach is proving extremely useful for identifying genes and pathways that contribute to complex clinical traits. Clearly, the coincidence of clinical trait quantitative trait loci and expression quantitative trait loci can help in the prioritization of positional candidate genes. Such data will be crucial for the formal integration of positional and transcriptomic information characterized as genetical genomics. A Oxford Academic 2012-07 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18849/1/17.pdf http://eprints.uanl.mx/18849/1.haspreviewThumbnailVersion/17.pdf Bastarrachea, Raúl A. y Gallegos Cabriales, Esther Carlota y Nava González, Edna Judith y Haack, Karin y Saroja Vorunganti, V. y Charlesworth, Jac y Laviada Molina, Hugo A. y Veloz Garza, Rosa A. y Cárdenas Villarreal, Velia Margarita y Valdovinos Chávez, Salvador H. y Gómez Aguilar, Patricia Isolina del Socorro y Meléndez, Guillermo y López Alvarenga, Juan Carlos y H. Góring, Harald H. y Cole, Shelley A. y Blangero, John y Comuzzie, Anthony G. y Kent, Jack W. (2012) Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence of the Identification of causal genes for cardiovascular and metabolic traits related to nutrition in mexicans1–3. Advances in nutrition, 3 (4). 596S-604S. doi:10.3945/an.112.001925. |
| spellingShingle | R Medicina en General Bastarrachea, Raúl A. Gallegos Cabriales, Esther Carlota Nava González, Edna Judith Haack, Karin Saroja Vorunganti, V. Charlesworth, Jac Laviada Molina, Hugo A. Veloz Garza, Rosa A. Cárdenas Villarreal, Velia Margarita Valdovinos Chávez, Salvador H. Gómez Aguilar, Patricia Isolina del Socorro Meléndez, Guillermo López Alvarenga, Juan Carlos H. Góring, Harald H. Cole, Shelley A. Blangero, John Comuzzie, Anthony G. Kent, Jack W. Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence of the Identification of causal genes for cardiovascular and metabolic traits related to nutrition in mexicans1–3 |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence
of the Identification of causal genes for
cardiovascular and metabolic traits related
to nutrition in mexicans1–3 |
| title_full | Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence
of the Identification of causal genes for
cardiovascular and metabolic traits related
to nutrition in mexicans1–3 |
| title_fullStr | Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence
of the Identification of causal genes for
cardiovascular and metabolic traits related
to nutrition in mexicans1–3 |
| title_full_unstemmed | Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence
of the Identification of causal genes for
cardiovascular and metabolic traits related
to nutrition in mexicans1–3 |
| title_short | Integrating genomic analysis with the genetic basis of gene expression: Preliminary Evidence
of the Identification of causal genes for
cardiovascular and metabolic traits related
to nutrition in mexicans1–3 |
| title_sort | integrating genomic analysis with the genetic basis of gene expression preliminary evidence of the identification of causal genes for cardiovascular and metabolic traits related to nutrition in mexicans1 3 |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/18849/1/17.pdf |
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