Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity
Centralnervoussystem(CNS)sensesenergyhomeostasisbyintegratingbothperipheralandautonomicsignalsandrespondingto thembyneurotransmittersandneuropeptidesrelease.Althoughitispreviouslyconsideredanimmunologicallyprivilegedorgan, we now know that this is not so. Cells belonging to the immune system, such a...
| Autores principales: | , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
|
| Acceso en línea: | http://eprints.uanl.mx/18272/1/561.pdf |
| _version_ | 1824415193389596672 |
|---|---|
| author | Maldonado Ruiz, Roger Alexis Fuentes Mera, Lizeth Camacho, Alberto |
| author_facet | Maldonado Ruiz, Roger Alexis Fuentes Mera, Lizeth Camacho, Alberto |
| author_sort | Maldonado Ruiz, Roger Alexis |
| collection | Repositorio Institucional |
| description | Centralnervoussystem(CNS)sensesenergyhomeostasisbyintegratingbothperipheralandautonomicsignalsandrespondingto thembyneurotransmittersandneuropeptidesrelease.Althoughitispreviouslyconsideredanimmunologicallyprivilegedorgan, we now know that this is not so. Cells belonging to the immune system, such as B and T lymphocytes, can be recruited into the CNS to face damage or infection, in addition to possessing resident immunological cells, called microglia. In this way, positive energybalanceduringobesitypromotesaninflammatorystateintheCNS.Saturatedfattyacidsfromthediethavebeenpointed out as powerful candidates to trigger immune response in peripheral system and in the CNS. However, how central immunity communicatestoperipheralimmuneresponseremainstobeclarified.Recentlytherehasbeenagreatinterestintheneuropeptides, POMC derived peptides, ghrelin, and leptin, due to their capacity to suppress or induce inflammatory responses in the brain, respectively. These may be potential candidates to treat different pathologies associated with autoimmunity and inflammation. In this review, we will discuss the role of lipotoxicity associated with positive energy balance during obesity in proinflammatory responseinmicroglia,BandTlymphocytes,anditsmodulationbyneuropeptides. |
| format | Article |
| id | eprints-18272 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-182722021-08-03T14:47:14Z http://eprints.uanl.mx/18272/ Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity Maldonado Ruiz, Roger Alexis Fuentes Mera, Lizeth Camacho, Alberto Centralnervoussystem(CNS)sensesenergyhomeostasisbyintegratingbothperipheralandautonomicsignalsandrespondingto thembyneurotransmittersandneuropeptidesrelease.Althoughitispreviouslyconsideredanimmunologicallyprivilegedorgan, we now know that this is not so. Cells belonging to the immune system, such as B and T lymphocytes, can be recruited into the CNS to face damage or infection, in addition to possessing resident immunological cells, called microglia. In this way, positive energybalanceduringobesitypromotesaninflammatorystateintheCNS.Saturatedfattyacidsfromthediethavebeenpointed out as powerful candidates to trigger immune response in peripheral system and in the CNS. However, how central immunity communicatestoperipheralimmuneresponseremainstobeclarified.Recentlytherehasbeenagreatinterestintheneuropeptides, POMC derived peptides, ghrelin, and leptin, due to their capacity to suppress or induce inflammatory responses in the brain, respectively. These may be potential candidates to treat different pathologies associated with autoimmunity and inflammation. In this review, we will discuss the role of lipotoxicity associated with positive energy balance during obesity in proinflammatory responseinmicroglia,BandTlymphocytes,anditsmodulationbyneuropeptides. 2017-08-23 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18272/1/561.pdf http://eprints.uanl.mx/18272/1.haspreviewThumbnailVersion/561.pdf Maldonado Ruiz, Roger Alexis y Fuentes Mera, Lizeth y Camacho, Alberto (2017) Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity. BioMed Research International, 2017. pp. 1-12. ISSN 2314-6133 http://doi.org/10.1155/2017/7949582 doi:10.1155/2017/7949582 |
| spellingShingle | Maldonado Ruiz, Roger Alexis Fuentes Mera, Lizeth Camacho, Alberto Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity |
| title_full | Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity |
| title_fullStr | Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity |
| title_full_unstemmed | Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity |
| title_short | Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity |
| title_sort | central modulation of neuroinflammation by neuropeptides and energy sensing hormones during obesity |
| url | http://eprints.uanl.mx/18272/1/561.pdf |
| work_keys_str_mv | AT maldonadoruizrogeralexis centralmodulationofneuroinflammationbyneuropeptidesandenergysensinghormonesduringobesity AT fuentesmeralizeth centralmodulationofneuroinflammationbyneuropeptidesandenergysensinghormonesduringobesity AT camachoalberto centralmodulationofneuroinflammationbyneuropeptidesandenergysensinghormonesduringobesity |