Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/18224/1/515.pdf |
| _version_ | 1824415175119208448 |
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| author | Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David |
| author_facet | Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David |
| author_sort | Jaime Pérez, José Carlos |
| collection | Repositorio Institucional |
| description | Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the
result of congenital marrow disease and chemical exposure;
however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an
human leukocyte antigen (HLA)-compatible donor relies on
the evidence that a deregulated immune system drives T
lymphocytes to cytokine-mediated destruction of their own
hematopoietic stem cells.1 The majority of these patients
respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is
successful in around 80%.2 Unfortunately, ATG and CsA can
lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria |
| format | Article |
| id | eprints-18224 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-182242020-03-10T14:54:52Z http://eprints.uanl.mx/18224/ Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David R Medicina en General Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human leukocyte antigen (HLA)-compatible donor relies on the evidence that a deregulated immune system drives T lymphocytes to cytokine-mediated destruction of their own hematopoietic stem cells.1 The majority of these patients respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is successful in around 80%.2 Unfortunately, ATG and CsA can lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria 2016-07-12 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18224/1/515.pdf http://eprints.uanl.mx/18224/1.haspreviewThumbnailVersion/515.pdf Jaime Pérez, José Carlos y Guerra Leal, Liliana Nataly y Cantú Rodríguez, Olga Graciela y Gómez Almaguer, David (2016) Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia. Revista Brasileira de Hematologia e Hemoterapia, 39 (1). pp. 57-59. ISSN 15168484 http://doi.org/10.1016/j.bjhh.2016.06.003 doi:10.1016/j.bjhh.2016.06.003 |
| spellingShingle | R Medicina en General Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
| title_full | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
| title_fullStr | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
| title_full_unstemmed | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
| title_short | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
| title_sort | myelodysplasia and acute myeloid leukemia fifteen years after high dose cyclophosphamide in a child with severe aplastic anemia |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/18224/1/515.pdf |
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