Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human...
Autores principales: | , , , |
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Formato: | Artículo |
Lenguaje: | inglés |
Publicado: |
2016
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Acceso en línea: | http://eprints.uanl.mx/18224/1/515.pdf |
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author | Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David |
author_facet | Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David |
author_sort | Jaime Pérez, José Carlos |
collection | Repositorio Institucional |
description | Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the
result of congenital marrow disease and chemical exposure;
however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an
human leukocyte antigen (HLA)-compatible donor relies on
the evidence that a deregulated immune system drives T
lymphocytes to cytokine-mediated destruction of their own
hematopoietic stem cells.1 The majority of these patients
respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is
successful in around 80%.2 Unfortunately, ATG and CsA can
lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria |
format | Article |
id | eprints-18224 |
institution | UANL |
language | English |
publishDate | 2016 |
record_format | eprints |
spelling | eprints-182242020-03-10T14:54:52Z http://eprints.uanl.mx/18224/ Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David R Medicina en General Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human leukocyte antigen (HLA)-compatible donor relies on the evidence that a deregulated immune system drives T lymphocytes to cytokine-mediated destruction of their own hematopoietic stem cells.1 The majority of these patients respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is successful in around 80%.2 Unfortunately, ATG and CsA can lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria 2016-07-12 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18224/1/515.pdf http://eprints.uanl.mx/18224/1.haspreviewThumbnailVersion/515.pdf Jaime Pérez, José Carlos y Guerra Leal, Liliana Nataly y Cantú Rodríguez, Olga Graciela y Gómez Almaguer, David (2016) Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia. Revista Brasileira de Hematologia e Hemoterapia, 39 (1). pp. 57-59. ISSN 15168484 http://doi.org/10.1016/j.bjhh.2016.06.003 doi:10.1016/j.bjhh.2016.06.003 |
spellingShingle | R Medicina en General Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
title | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
title_full | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
title_fullStr | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
title_full_unstemmed | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
title_short | Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia |
title_sort | myelodysplasia and acute myeloid leukemia fifteen years after high dose cyclophosphamide in a child with severe aplastic anemia |
topic | R Medicina en General |
url | http://eprints.uanl.mx/18224/1/515.pdf |
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