Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia

Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human...

Descripción completa

Detalles Bibliográficos
Autores principales: Jaime Pérez, José Carlos, Guerra Leal, Liliana Nataly, Cantú Rodríguez, Olga Graciela, Gómez Almaguer, David
Formato: Artículo
Lenguaje:inglés
Publicado: 2016
Materias:
Acceso en línea:http://eprints.uanl.mx/18224/1/515.pdf
_version_ 1824415175119208448
author Jaime Pérez, José Carlos
Guerra Leal, Liliana Nataly
Cantú Rodríguez, Olga Graciela
Gómez Almaguer, David
author_facet Jaime Pérez, José Carlos
Guerra Leal, Liliana Nataly
Cantú Rodríguez, Olga Graciela
Gómez Almaguer, David
author_sort Jaime Pérez, José Carlos
collection Repositorio Institucional
description Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human leukocyte antigen (HLA)-compatible donor relies on the evidence that a deregulated immune system drives T lymphocytes to cytokine-mediated destruction of their own hematopoietic stem cells.1 The majority of these patients respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is successful in around 80%.2 Unfortunately, ATG and CsA can lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria
format Article
id eprints-18224
institution UANL
language English
publishDate 2016
record_format eprints
spelling eprints-182242020-03-10T14:54:52Z http://eprints.uanl.mx/18224/ Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia Jaime Pérez, José Carlos Guerra Leal, Liliana Nataly Cantú Rodríguez, Olga Graciela Gómez Almaguer, David R Medicina en General Aplastic anemia (AA) is a rare disorder characterized by suppression of bone marrow function. It can develop as the result of congenital marrow disease and chemical exposure; however, most cases are idiopathic.1 Treatment with immunosuppressive therapy (IST) for patients who do not have an human leukocyte antigen (HLA)-compatible donor relies on the evidence that a deregulated immune system drives T lymphocytes to cytokine-mediated destruction of their own hematopoietic stem cells.1 The majority of these patients respond well to up-front administration of IST, including antithymocyte globulin (ATG) and cyclosporine (CsA), which is successful in around 80%.2 Unfortunately, ATG and CsA can lead to clonal disorders, in particular myelodysplastic syndrome (MDS) and paroxysmal nocturnal hemoglobinuria 2016-07-12 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18224/1/515.pdf http://eprints.uanl.mx/18224/1.haspreviewThumbnailVersion/515.pdf Jaime Pérez, José Carlos y Guerra Leal, Liliana Nataly y Cantú Rodríguez, Olga Graciela y Gómez Almaguer, David (2016) Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia. Revista Brasileira de Hematologia e Hemoterapia, 39 (1). pp. 57-59. ISSN 15168484 http://doi.org/10.1016/j.bjhh.2016.06.003 doi:10.1016/j.bjhh.2016.06.003
spellingShingle R Medicina en General
Jaime Pérez, José Carlos
Guerra Leal, Liliana Nataly
Cantú Rodríguez, Olga Graciela
Gómez Almaguer, David
Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
title_full Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
title_fullStr Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
title_full_unstemmed Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
title_short Myelodysplasia and acute myeloid leukemia fifteen years after high-dose cyclophosphamide in a child with severe aplastic anemia
title_sort myelodysplasia and acute myeloid leukemia fifteen years after high dose cyclophosphamide in a child with severe aplastic anemia
topic R Medicina en General
url http://eprints.uanl.mx/18224/1/515.pdf
work_keys_str_mv AT jaimeperezjosecarlos myelodysplasiaandacutemyeloidleukemiafifteenyearsafterhighdosecyclophosphamideinachildwithsevereaplasticanemia
AT guerralealliliananataly myelodysplasiaandacutemyeloidleukemiafifteenyearsafterhighdosecyclophosphamideinachildwithsevereaplasticanemia
AT canturodriguezolgagraciela myelodysplasiaandacutemyeloidleukemiafifteenyearsafterhighdosecyclophosphamideinachildwithsevereaplasticanemia
AT gomezalmaguerdavid myelodysplasiaandacutemyeloidleukemiafifteenyearsafterhighdosecyclophosphamideinachildwithsevereaplasticanemia