Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study
Abstract Background: Metabolic syndrome (MetS) is a major risk factor for cardiovascular disease and diabetes. Previous studies in obese children demonstrating a positive association between serum uric acid (sUA) and components of MetS are confounded by lack of uniformity in age and pubertal stat...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/18172/1/458.pdf |
| _version_ | 1838551000636456960 |
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| author | Solís Pérez, Elizabeth González Medina, Mario Alberto López Cabanillas Lomelí, Manuel Tijerina González, Verónica Villarreal Pérez, Jesús Zacarías Imrhan, Victorine Juma, Shanil Vijayagopal, Parakat Boonme, Kittipong Prasad, Chandan |
| author_facet | Solís Pérez, Elizabeth González Medina, Mario Alberto López Cabanillas Lomelí, Manuel Tijerina González, Verónica Villarreal Pérez, Jesús Zacarías Imrhan, Victorine Juma, Shanil Vijayagopal, Parakat Boonme, Kittipong Prasad, Chandan |
| author_sort | Solís Pérez, Elizabeth |
| collection | Repositorio Institucional |
| description | Abstract
Background: Metabolic syndrome (MetS) is a major risk factor for cardiovascular disease and diabetes. Previous
studies in obese children demonstrating a positive association between serum uric acid (sUA) and components of
MetS are confounded by lack of uniformity in age and pubertal status of children. Therefore, we have examined the
role of sUA in MetS and its components in pre-pubertal children (Tanner Stage I, age ≤ 9 years).
Methods: Pre-pubertal obese children (32 boys, 27 girls, age 6–9 years) were recruited from Nuevo Leon, Mexico.
For comparison, an equal number of children with normal body mass index (BMI) in the same age range (22 Boys,
39 girls, age 6–9 years) were also recruited from the same community. Presence of MetS and its components was
defined according to the criteria of International Diabetes Federation. Fasting blood was analyzed for lipids, glucose,
insulin, and uric acid.
Results: Among the obese children, sUA was positively associated with insulin resistance and hypertriglyceridemia
and negatively associated with high density lipoprotein-cholesterol (HDLc). Subjects were three times more likely to
have a MetS diagnosis per one unit (md/dL) difference in sUA. Of the 59 obese pre-pubertal children, 20 were
classified as having MetS defined by the presence of abdominal obesity and two or more of other components
described under methods. Of these, 57.1% (20/61) had sUA between 5.1 and 7.1 mg/dl.
Conclusions: The findings of this study clearly indicate a positive relationship between uric acid and MetS and its
components in pre-pubertal obese children with Tanner stage I and ≤9 years of age. |
| format | Article |
| id | eprints-18172 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-181722025-07-10T16:16:15Z http://eprints.uanl.mx/18172/ Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study Solís Pérez, Elizabeth González Medina, Mario Alberto López Cabanillas Lomelí, Manuel Tijerina González, Verónica Villarreal Pérez, Jesús Zacarías Imrhan, Victorine Juma, Shanil Vijayagopal, Parakat Boonme, Kittipong Prasad, Chandan R Medicina en General Abstract Background: Metabolic syndrome (MetS) is a major risk factor for cardiovascular disease and diabetes. Previous studies in obese children demonstrating a positive association between serum uric acid (sUA) and components of MetS are confounded by lack of uniformity in age and pubertal status of children. Therefore, we have examined the role of sUA in MetS and its components in pre-pubertal children (Tanner Stage I, age ≤ 9 years). Methods: Pre-pubertal obese children (32 boys, 27 girls, age 6–9 years) were recruited from Nuevo Leon, Mexico. For comparison, an equal number of children with normal body mass index (BMI) in the same age range (22 Boys, 39 girls, age 6–9 years) were also recruited from the same community. Presence of MetS and its components was defined according to the criteria of International Diabetes Federation. Fasting blood was analyzed for lipids, glucose, insulin, and uric acid. Results: Among the obese children, sUA was positively associated with insulin resistance and hypertriglyceridemia and negatively associated with high density lipoprotein-cholesterol (HDLc). Subjects were three times more likely to have a MetS diagnosis per one unit (md/dL) difference in sUA. Of the 59 obese pre-pubertal children, 20 were classified as having MetS defined by the presence of abdominal obesity and two or more of other components described under methods. Of these, 57.1% (20/61) had sUA between 5.1 and 7.1 mg/dl. Conclusions: The findings of this study clearly indicate a positive relationship between uric acid and MetS and its components in pre-pubertal obese children with Tanner stage I and ≤9 years of age. 2017 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18172/1/458.pdf http://eprints.uanl.mx/18172/1.haspreviewThumbnailVersion/458.pdf Solís Pérez, Elizabeth y González Medina, Mario Alberto y López Cabanillas Lomelí, Manuel y Tijerina González, Verónica y Villarreal Pérez, Jesús Zacarías y Imrhan, Victorine y Juma, Shanil y Vijayagopal, Parakat y Boonme, Kittipong y Prasad, Chandan (2017) Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study. BMC Obesity, 4 (1). pp. 1-7. ISSN 2052-9538 http://doi.org/10.1186/s40608-017-0160-6 doi:10.1186/s40608-017-0160-6 |
| spellingShingle | R Medicina en General Solís Pérez, Elizabeth González Medina, Mario Alberto López Cabanillas Lomelí, Manuel Tijerina González, Verónica Villarreal Pérez, Jesús Zacarías Imrhan, Victorine Juma, Shanil Vijayagopal, Parakat Boonme, Kittipong Prasad, Chandan Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study |
| title_full | Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study |
| title_fullStr | Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study |
| title_full_unstemmed | Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study |
| title_short | Association between serum uric acid and metabolic syndrome components in prepubertal obese children (Tanner Stage I) from Nuevo León, Mexico - a preliminary study |
| title_sort | association between serum uric acid and metabolic syndrome components in prepubertal obese children tanner stage i from nuevo leon mexico a preliminary study |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/18172/1/458.pdf |
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