| Sumario: | ABSTRACT
A controlled, parallel, randomized and comparative trial was carried out to evaluate the antiinflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar
surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated
using the method of Amin and Laskin, and the analysis of cytokine production (IL-2, IL-4, IL-6, IL-10,
TNF-a, INF-g) in saliva was done by flow cytometry. The swelling process after surgery was
significant (p < 0.05) and the treatments with IMMUNEPOTENT CRP or ibuprofen controlled this
process properly; no difference between the groups was found (p < 0.05). Both treatments were
shown to modulate the cytokine production. These results demonstrate the anti-inflammatory
activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical
dental practice.
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