Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study
Abstract. The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 sin...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Acceso en línea: | http://eprints.uanl.mx/18143/1/441.pdf |
| _version_ | 1824415147140055040 |
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| author | Gallardo Blanco, Hugo Leonid Villarreal Pérez, Jesús Zacarías Cerda Flores, Ricardo Martín Figueroa, Andres Sánchez Domínguez, Celia Nohemí Gutiérrez Valverde, Juana Mercedes Torres Muñoz, Iris Carmen Lavalle González, Fernando Javier Gallegos Cabriales, Esther Carlota Martínez Garza, Laura Elia |
| author_facet | Gallardo Blanco, Hugo Leonid Villarreal Pérez, Jesús Zacarías Cerda Flores, Ricardo Martín Figueroa, Andres Sánchez Domínguez, Celia Nohemí Gutiérrez Valverde, Juana Mercedes Torres Muñoz, Iris Carmen Lavalle González, Fernando Javier Gallegos Cabriales, Esther Carlota Martínez Garza, Laura Elia |
| author_sort | Gallardo Blanco, Hugo Leonid |
| collection | Repositorio Institucional |
| description | Abstract. The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 SNP rs5210 was associated with T2DM, the TCF7L2 SNP rs11196175 was associated with BMI and cholesterol and LDL
levels, the TCF7L2 SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the HNF4A SNP rs1885088 was associated with LDL levels (P<0.05). |
| format | Article |
| id | eprints-18143 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-181432024-03-05T15:36:37Z http://eprints.uanl.mx/18143/ Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study Gallardo Blanco, Hugo Leonid Villarreal Pérez, Jesús Zacarías Cerda Flores, Ricardo Martín Figueroa, Andres Sánchez Domínguez, Celia Nohemí Gutiérrez Valverde, Juana Mercedes Torres Muñoz, Iris Carmen Lavalle González, Fernando Javier Gallegos Cabriales, Esther Carlota Martínez Garza, Laura Elia R Medicina en General Abstract. The aim of the present study was to investigate whether genetic markers considered risk factors for metabolic syndromes, including dyslipidemia, obesity and type 2 diabetes mellitus (T2DM), can be applied to a Northeastern Mexican population. A total of 37 families were analyzed for 63 single nucleotide polymorphisms (SNPs), and the age, body mass index (BMI), glucose tolerance values and blood lipid levels, including those of cholesterol, low-density lipoprotein (LDL), very LDL (VLDL), high-density lipoprotein (HDL) and triglycerides were evaluated. Three genetic markers previously associated with metabolic syndromes were identified in the sample population, including KCNJ11, TCF7L2 and HNF4A. The KCNJ11 SNP rs5210 was associated with T2DM, the TCF7L2 SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the TCF7L2 SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the HNF4A SNP rs1885088 was associated with LDL levels (P<0.05). 2016-01-20 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/18143/1/441.pdf http://eprints.uanl.mx/18143/1.haspreviewThumbnailVersion/441.pdf Gallardo Blanco, Hugo Leonid y Villarreal Pérez, Jesús Zacarías y Cerda Flores, Ricardo Martín y Figueroa, Andres y Sánchez Domínguez, Celia Nohemí y Gutiérrez Valverde, Juana Mercedes y Torres Muñoz, Iris Carmen y Lavalle González, Fernando Javier y Gallegos Cabriales, Esther Carlota y Martínez Garza, Laura Elia (2016) Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study. Experimental and Therapeutic Medicine, 13 (2). pp. 523-529. ISSN 1792-0981 http://doi.org/10.3892/etm.2016.3990 doi:10.3892/etm.2016.3990 |
| spellingShingle | R Medicina en General Gallardo Blanco, Hugo Leonid Villarreal Pérez, Jesús Zacarías Cerda Flores, Ricardo Martín Figueroa, Andres Sánchez Domínguez, Celia Nohemí Gutiérrez Valverde, Juana Mercedes Torres Muñoz, Iris Carmen Lavalle González, Fernando Javier Gallegos Cabriales, Esther Carlota Martínez Garza, Laura Elia Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study |
| title_full | Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study |
| title_fullStr | Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study |
| title_full_unstemmed | Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study |
| title_short | Genetic variants in KCNJ11, TCF7L2 and HNF4A are associated with type 2 diabetes, BMI and dyslipidemia in families of Northeastern Mexico: A pilot study |
| title_sort | genetic variants in kcnj11 tcf7l2 and hnf4a are associated with type 2 diabetes bmi and dyslipidemia in families of northeastern mexico a pilot study |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/18143/1/441.pdf |
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