Transancestral mapping and genetic load in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/17573/1/357.pdf |
| _version_ | 1824414939847065600 |
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| author | Langefeld, Carl D. Ainsworth, Hannah C. Cunninghame Graham, Deborah S. Kelly, Jennifer A. Comeau, Mary E. Marion, Miranda C. Howard, Timothy D. Ramos, Paula S. Croker, Jennifer A. Morris, David L. Sandling, Johanna K. Almlöf, Jonas Carlsson Acevedo Vásquez, Eduardo M. Alarcón, Graciela S. Babini, Alejandra M. Baca, Vicente Bengtsson, Anders A. Berbotto, Guillermo A. Bijl, Marc Brown, Elizabeth E. Brunner, Hermine I. Cardiel, Mario H. Catoggio, Luis Cervera, Ricard Cucho Venegas, Jorge M. Dahlqvist, Solbritt Rantapää D’Alfonso, Sandra Da Silva, Berta Martins De la Rúa Figueroa, Iñigo Doria, Andrea Edberg, Jeffrey C. Endreffy, Emőke Esquivel Valerio, Jorge Antonio Fortin, Paul R. Freedman, Barry I. Frostegård, Johan García, Mercedes A. García de la Torre, Ignacio Gilkeson, Gary S. Gladman, Dafna D. Gunnarsson, Iva Guthridge, Joel M. Huggins, Jennifer L. James, Judith A. Kallenberg, Cees G. M. Kamen, Diane L. Karp, David R. Kaufman, Kenneth M. Kottyan, Leah C. Kovács, László Laustrup, Helle Lauwerys, Bernard R. Li, Quan Zhen Maradiaga Ceceña, Marco A. Martín, Javier McCune, Joseph M. McWilliams, David R. Merrill, Joan T. Miranda, Pedro Moctezuma, José F. Nath, Swapan K. Niewold, Timothy B. Orozco, Lorena Ortego Centeno, Norberto Petri, Michelle Pineau, Christian A. Pons Estel, Bernardo A. Pope, Janet Raj, Prithvi Ramsey Goldman, Rosalind Reveille, John D. Russell, Laurie P. Sabio, José M. Aguilar Salinas, Carlos Alberto Scherbarth, Hugo R. Scorza, Raffaella Seldin, Michael F. Sjöwall, Christopher Svenungsson, Elisabet Thompson, Susan D. Toloza, Sergio M. A. Truedsson, Lennart Tusié Luna, Teresa Vasconcelos, Carlos Vilá, Luis M. Wallace, Daniel J. Weisman, Michael H. Wither, Joan E. Bhangale, Tushar Oksenberg, Jorge R. Rioux, John D. Gregersen, Peter K. Syvänen, Ann Christine Rönnblom, Lars Criswell, Lindsey A. Jacob, Chaim O. Sivils, Kathy L. Tsao, Betty P. Schanberg, Laura E. Behrens, Timothy W. Silverman, Earl D. Alarcón Riquelme, Marta E. Kimberly, Robert P. Harley, John B. Wakeland, Edward K. Graham, Robert R. Gaffney, Patrick M. Vyse, Timothy J. |
| author_facet | Langefeld, Carl D. Ainsworth, Hannah C. Cunninghame Graham, Deborah S. Kelly, Jennifer A. Comeau, Mary E. Marion, Miranda C. Howard, Timothy D. Ramos, Paula S. Croker, Jennifer A. Morris, David L. Sandling, Johanna K. Almlöf, Jonas Carlsson Acevedo Vásquez, Eduardo M. Alarcón, Graciela S. Babini, Alejandra M. Baca, Vicente Bengtsson, Anders A. Berbotto, Guillermo A. Bijl, Marc Brown, Elizabeth E. Brunner, Hermine I. Cardiel, Mario H. Catoggio, Luis Cervera, Ricard Cucho Venegas, Jorge M. Dahlqvist, Solbritt Rantapää D’Alfonso, Sandra Da Silva, Berta Martins De la Rúa Figueroa, Iñigo Doria, Andrea Edberg, Jeffrey C. Endreffy, Emőke Esquivel Valerio, Jorge Antonio Fortin, Paul R. Freedman, Barry I. Frostegård, Johan García, Mercedes A. García de la Torre, Ignacio Gilkeson, Gary S. Gladman, Dafna D. Gunnarsson, Iva Guthridge, Joel M. Huggins, Jennifer L. James, Judith A. Kallenberg, Cees G. M. Kamen, Diane L. Karp, David R. Kaufman, Kenneth M. Kottyan, Leah C. Kovács, László Laustrup, Helle Lauwerys, Bernard R. Li, Quan Zhen Maradiaga Ceceña, Marco A. Martín, Javier McCune, Joseph M. McWilliams, David R. Merrill, Joan T. Miranda, Pedro Moctezuma, José F. Nath, Swapan K. Niewold, Timothy B. Orozco, Lorena Ortego Centeno, Norberto Petri, Michelle Pineau, Christian A. Pons Estel, Bernardo A. Pope, Janet Raj, Prithvi Ramsey Goldman, Rosalind Reveille, John D. Russell, Laurie P. Sabio, José M. Aguilar Salinas, Carlos Alberto Scherbarth, Hugo R. Scorza, Raffaella Seldin, Michael F. Sjöwall, Christopher Svenungsson, Elisabet Thompson, Susan D. Toloza, Sergio M. A. Truedsson, Lennart Tusié Luna, Teresa Vasconcelos, Carlos Vilá, Luis M. Wallace, Daniel J. Weisman, Michael H. Wither, Joan E. Bhangale, Tushar Oksenberg, Jorge R. Rioux, John D. Gregersen, Peter K. Syvänen, Ann Christine Rönnblom, Lars Criswell, Lindsey A. Jacob, Chaim O. Sivils, Kathy L. Tsao, Betty P. Schanberg, Laura E. Behrens, Timothy W. Silverman, Earl D. Alarcón Riquelme, Marta E. Kimberly, Robert P. Harley, John B. Wakeland, Edward K. Graham, Robert R. Gaffney, Patrick M. Vyse, Timothy J. |
| author_sort | Langefeld, Carl D. |
| collection | Repositorio Institucional |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (B50% of these regions have multiple independent associations); these include 24 novel SLE regions (Po5 10 8), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE |
| format | Article |
| id | eprints-17573 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | eprints |
| spelling | eprints-175732021-05-04T15:17:33Z http://eprints.uanl.mx/17573/ Transancestral mapping and genetic load in systemic lupus erythematosus Langefeld, Carl D. Ainsworth, Hannah C. Cunninghame Graham, Deborah S. Kelly, Jennifer A. Comeau, Mary E. Marion, Miranda C. Howard, Timothy D. Ramos, Paula S. Croker, Jennifer A. Morris, David L. Sandling, Johanna K. Almlöf, Jonas Carlsson Acevedo Vásquez, Eduardo M. Alarcón, Graciela S. Babini, Alejandra M. Baca, Vicente Bengtsson, Anders A. Berbotto, Guillermo A. Bijl, Marc Brown, Elizabeth E. Brunner, Hermine I. Cardiel, Mario H. Catoggio, Luis Cervera, Ricard Cucho Venegas, Jorge M. Dahlqvist, Solbritt Rantapää D’Alfonso, Sandra Da Silva, Berta Martins De la Rúa Figueroa, Iñigo Doria, Andrea Edberg, Jeffrey C. Endreffy, Emőke Esquivel Valerio, Jorge Antonio Fortin, Paul R. Freedman, Barry I. Frostegård, Johan García, Mercedes A. García de la Torre, Ignacio Gilkeson, Gary S. Gladman, Dafna D. Gunnarsson, Iva Guthridge, Joel M. Huggins, Jennifer L. James, Judith A. Kallenberg, Cees G. M. Kamen, Diane L. Karp, David R. Kaufman, Kenneth M. Kottyan, Leah C. Kovács, László Laustrup, Helle Lauwerys, Bernard R. Li, Quan Zhen Maradiaga Ceceña, Marco A. Martín, Javier McCune, Joseph M. McWilliams, David R. Merrill, Joan T. Miranda, Pedro Moctezuma, José F. Nath, Swapan K. Niewold, Timothy B. Orozco, Lorena Ortego Centeno, Norberto Petri, Michelle Pineau, Christian A. Pons Estel, Bernardo A. Pope, Janet Raj, Prithvi Ramsey Goldman, Rosalind Reveille, John D. Russell, Laurie P. Sabio, José M. Aguilar Salinas, Carlos Alberto Scherbarth, Hugo R. Scorza, Raffaella Seldin, Michael F. Sjöwall, Christopher Svenungsson, Elisabet Thompson, Susan D. Toloza, Sergio M. A. Truedsson, Lennart Tusié Luna, Teresa Vasconcelos, Carlos Vilá, Luis M. Wallace, Daniel J. Weisman, Michael H. Wither, Joan E. Bhangale, Tushar Oksenberg, Jorge R. Rioux, John D. Gregersen, Peter K. Syvänen, Ann Christine Rönnblom, Lars Criswell, Lindsey A. Jacob, Chaim O. Sivils, Kathy L. Tsao, Betty P. Schanberg, Laura E. Behrens, Timothy W. Silverman, Earl D. Alarcón Riquelme, Marta E. Kimberly, Robert P. Harley, John B. Wakeland, Edward K. Graham, Robert R. Gaffney, Patrick M. Vyse, Timothy J. QH Historia Natural, Biología Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (B50% of these regions have multiple independent associations); these include 24 novel SLE regions (Po5 10 8), refined association signals in established regions, extended associations to additional ancestries, and a disentangled complex HLA multigenic effect. The risk allele count (genetic load) exhibits an accelerating pattern of SLE risk, leading us to posit a cumulative hit hypothesis for autoimmune disease. Comparing results across the three ancestries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk. Our results are consistent with the unique and complex histories of the populations sampled, and collectively help clarify the genetic architecture and ethnic disparities in SLE Nature Publishing Group 2017-07 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/17573/1/357.pdf http://eprints.uanl.mx/17573/1.haspreviewThumbnailVersion/357.pdf Langefeld, Carl D. y Ainsworth, Hannah C. y Cunninghame Graham, Deborah S. y Kelly, Jennifer A. y Comeau, Mary E. y Marion, Miranda C. y Howard, Timothy D. y Ramos, Paula S. y Croker, Jennifer A. y Morris, David L. y Sandling, Johanna K. y Almlöf, Jonas Carlsson y Acevedo Vásquez, Eduardo M. y Alarcón, Graciela S. y Babini, Alejandra M. y Baca, Vicente y Bengtsson, Anders A. y Berbotto, Guillermo A. y Bijl, Marc y Brown, Elizabeth E. y Brunner, Hermine I. y Cardiel, Mario H. y Catoggio, Luis y Cervera, Ricard y Cucho Venegas, Jorge M. y Dahlqvist, Solbritt Rantapää y D’Alfonso, Sandra y Da Silva, Berta Martins y De la Rúa Figueroa, Iñigo y Doria, Andrea y Edberg, Jeffrey C. y Endreffy, Emőke y Esquivel Valerio, Jorge Antonio y Fortin, Paul R. y Freedman, Barry I. y Frostegård, Johan y García, Mercedes A. y García de la Torre, Ignacio y Gilkeson, Gary S. y Gladman, Dafna D. y Gunnarsson, Iva y Guthridge, Joel M. y Huggins, Jennifer L. y James, Judith A. y Kallenberg, Cees G. M. y Kamen, Diane L. y Karp, David R. y Kaufman, Kenneth M. y Kottyan, Leah C. y Kovács, László y Laustrup, Helle y Lauwerys, Bernard R. y Li, Quan Zhen y Maradiaga Ceceña, Marco A. y Martín, Javier y McCune, Joseph M. y McWilliams, David R. y Merrill, Joan T. y Miranda, Pedro y Moctezuma, José F. y Nath, Swapan K. y Niewold, Timothy B. y Orozco, Lorena y Ortego Centeno, Norberto y Petri, Michelle y Pineau, Christian A. y Pons Estel, Bernardo A. y Pope, Janet y Raj, Prithvi y Ramsey Goldman, Rosalind y Reveille, John D. y Russell, Laurie P. y Sabio, José M. y Aguilar Salinas, Carlos Alberto y Scherbarth, Hugo R. y Scorza, Raffaella y Seldin, Michael F. y Sjöwall, Christopher y Svenungsson, Elisabet y Thompson, Susan D. y Toloza, Sergio M. A. y Truedsson, Lennart y Tusié Luna, Teresa y Vasconcelos, Carlos y Vilá, Luis M. y Wallace, Daniel J. y Weisman, Michael H. y Wither, Joan E. y Bhangale, Tushar y Oksenberg, Jorge R. y Rioux, John D. y Gregersen, Peter K. y Syvänen, Ann Christine y Rönnblom, Lars y Criswell, Lindsey A. y Jacob, Chaim O. y Sivils, Kathy L. y Tsao, Betty P. y Schanberg, Laura E. y Behrens, Timothy W. y Silverman, Earl D. y Alarcón Riquelme, Marta E. y Kimberly, Robert P. y Harley, John B. y Wakeland, Edward K. y Graham, Robert R. y Gaffney, Patrick M. y Vyse, Timothy J. (2017) Transancestral mapping and genetic load in systemic lupus erythematosus. Nature Communications, 8 (1). pp. 1-18. ISSN 2041-1723 http://doi.org/10.1038/ncomms16021 doi:10.1038/ncomms16021 |
| spellingShingle | QH Historia Natural, Biología Langefeld, Carl D. Ainsworth, Hannah C. Cunninghame Graham, Deborah S. Kelly, Jennifer A. Comeau, Mary E. Marion, Miranda C. Howard, Timothy D. Ramos, Paula S. Croker, Jennifer A. Morris, David L. Sandling, Johanna K. Almlöf, Jonas Carlsson Acevedo Vásquez, Eduardo M. Alarcón, Graciela S. Babini, Alejandra M. Baca, Vicente Bengtsson, Anders A. Berbotto, Guillermo A. Bijl, Marc Brown, Elizabeth E. Brunner, Hermine I. Cardiel, Mario H. Catoggio, Luis Cervera, Ricard Cucho Venegas, Jorge M. Dahlqvist, Solbritt Rantapää D’Alfonso, Sandra Da Silva, Berta Martins De la Rúa Figueroa, Iñigo Doria, Andrea Edberg, Jeffrey C. Endreffy, Emőke Esquivel Valerio, Jorge Antonio Fortin, Paul R. Freedman, Barry I. Frostegård, Johan García, Mercedes A. García de la Torre, Ignacio Gilkeson, Gary S. Gladman, Dafna D. Gunnarsson, Iva Guthridge, Joel M. Huggins, Jennifer L. James, Judith A. Kallenberg, Cees G. M. Kamen, Diane L. Karp, David R. Kaufman, Kenneth M. Kottyan, Leah C. Kovács, László Laustrup, Helle Lauwerys, Bernard R. Li, Quan Zhen Maradiaga Ceceña, Marco A. Martín, Javier McCune, Joseph M. McWilliams, David R. Merrill, Joan T. Miranda, Pedro Moctezuma, José F. Nath, Swapan K. Niewold, Timothy B. Orozco, Lorena Ortego Centeno, Norberto Petri, Michelle Pineau, Christian A. Pons Estel, Bernardo A. Pope, Janet Raj, Prithvi Ramsey Goldman, Rosalind Reveille, John D. Russell, Laurie P. Sabio, José M. Aguilar Salinas, Carlos Alberto Scherbarth, Hugo R. Scorza, Raffaella Seldin, Michael F. Sjöwall, Christopher Svenungsson, Elisabet Thompson, Susan D. Toloza, Sergio M. A. Truedsson, Lennart Tusié Luna, Teresa Vasconcelos, Carlos Vilá, Luis M. Wallace, Daniel J. Weisman, Michael H. Wither, Joan E. Bhangale, Tushar Oksenberg, Jorge R. Rioux, John D. Gregersen, Peter K. Syvänen, Ann Christine Rönnblom, Lars Criswell, Lindsey A. Jacob, Chaim O. Sivils, Kathy L. Tsao, Betty P. Schanberg, Laura E. Behrens, Timothy W. Silverman, Earl D. Alarcón Riquelme, Marta E. Kimberly, Robert P. Harley, John B. Wakeland, Edward K. Graham, Robert R. Gaffney, Patrick M. Vyse, Timothy J. Transancestral mapping and genetic load in systemic lupus erythematosus |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_full | Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_fullStr | Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_full_unstemmed | Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_short | Transancestral mapping and genetic load in systemic lupus erythematosus |
| title_sort | transancestral mapping and genetic load in systemic lupus erythematosus |
| topic | QH Historia Natural, Biología |
| url | http://eprints.uanl.mx/17573/1/357.pdf |
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