The dawn of the liquid biopsy in the fight against cancer
ABSTRACT Cancer is a molecular disease associated with alterations in the genome, which, thanks to the highly improved sensitivity of mutation detection techniques, can be identified in cell-free DNA (cfDNA) circulating in blood, a method also called liquid biopsy. This is a non-invasive alternative...
| Autores principales: | , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Acceso en línea: | http://eprints.uanl.mx/17421/1/280.pdf |
| _version_ | 1824414893489520640 |
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| author | Domínguez Vigil, Irma Guadalupe Moreno Martínez, Ana K. Wang, Julia Y. Roehrl, Michael H. A. Barrera Saldaña, Hugo Alberto |
| author_facet | Domínguez Vigil, Irma Guadalupe Moreno Martínez, Ana K. Wang, Julia Y. Roehrl, Michael H. A. Barrera Saldaña, Hugo Alberto |
| author_sort | Domínguez Vigil, Irma Guadalupe |
| collection | Repositorio Institucional |
| description | ABSTRACT Cancer is a molecular disease associated with alterations in the genome, which, thanks to the highly improved sensitivity of mutation detection techniques, can be identified in cell-free DNA (cfDNA) circulating in blood, a method also called liquid biopsy. This is a non-invasive alternative to surgical biopsy and has the potential of revealing the molecular signature of tumors to aid in the individualization of treatments. In this review, we focus on cfDNA analysis, its advantages, and clinical applications employing genomic tools (NGS and dPCR) particularly in the field of oncology, and highlight its valuable contributions to early detection, prognosis, and prediction of treatment response. |
| format | Article |
| id | eprints-17421 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-174212024-12-09T17:44:37Z http://eprints.uanl.mx/17421/ The dawn of the liquid biopsy in the fight against cancer Domínguez Vigil, Irma Guadalupe Moreno Martínez, Ana K. Wang, Julia Y. Roehrl, Michael H. A. Barrera Saldaña, Hugo Alberto ABSTRACT Cancer is a molecular disease associated with alterations in the genome, which, thanks to the highly improved sensitivity of mutation detection techniques, can be identified in cell-free DNA (cfDNA) circulating in blood, a method also called liquid biopsy. This is a non-invasive alternative to surgical biopsy and has the potential of revealing the molecular signature of tumors to aid in the individualization of treatments. In this review, we focus on cfDNA analysis, its advantages, and clinical applications employing genomic tools (NGS and dPCR) particularly in the field of oncology, and highlight its valuable contributions to early detection, prognosis, and prediction of treatment response. 2017-12-08 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/17421/1/280.pdf http://eprints.uanl.mx/17421/1.haspreviewThumbnailVersion/280.pdf Domínguez Vigil, Irma Guadalupe y Moreno Martínez, Ana K. y Wang, Julia Y. y Roehrl, Michael H. A. y Barrera Saldaña, Hugo Alberto (2017) The dawn of the liquid biopsy in the fight against cancer. Oncotarget, 9 (2). pp. 2912-2922. ISSN 1949-2553 http://doi.org/10.18632/oncotarget.23131 doi:10.18632/oncotarget.23131 |
| spellingShingle | Domínguez Vigil, Irma Guadalupe Moreno Martínez, Ana K. Wang, Julia Y. Roehrl, Michael H. A. Barrera Saldaña, Hugo Alberto The dawn of the liquid biopsy in the fight against cancer |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | The dawn of the liquid biopsy in the fight against cancer |
| title_full | The dawn of the liquid biopsy in the fight against cancer |
| title_fullStr | The dawn of the liquid biopsy in the fight against cancer |
| title_full_unstemmed | The dawn of the liquid biopsy in the fight against cancer |
| title_short | The dawn of the liquid biopsy in the fight against cancer |
| title_sort | dawn of the liquid biopsy in the fight against cancer |
| url | http://eprints.uanl.mx/17421/1/280.pdf |
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