Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring
Obesity or maternal overnutrition during pregnancy and lactation might have long-term consequences in offspring health. Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages. Programming alters gene expression through epigenetic modif...
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/17417/1/276.pdf |
| _version_ | 1838550998231023616 |
|---|---|
| author | Montalvo Martínez, Larisa Jajaira Maldonado Ruiz, Roger Alexis Cárdenas Tueme, Marcela Reséndez Pérez, Diana Camacho Morales, Alberto |
| author_facet | Montalvo Martínez, Larisa Jajaira Maldonado Ruiz, Roger Alexis Cárdenas Tueme, Marcela Reséndez Pérez, Diana Camacho Morales, Alberto |
| author_sort | Montalvo Martínez, Larisa Jajaira |
| collection | Repositorio Institucional |
| description | Obesity or maternal overnutrition during pregnancy and lactation might have long-term consequences in offspring health. Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages. Programming
alters gene expression through epigenetic modifications leading to a transgenerational effect of behavioral phenotypes in the
offspring. Maternal intake of hypercaloric diets during fetal development programs aberrant behaviors resembling addiction in
offspring. Programming by hypercaloric surplus sets a gene expression pattern modulating axonal pruning, synaptic signaling, and
synaptic plasticity in selective regions of the reward system. Likewise, fetal programming can promote an inflammatory phenotype
in peripheral and central sites through different cell types such as microglia and T and B cells, which contribute to disrupted energy
sensing and behavioral pathways. Te molecular mechanism that regulates the central and peripheral immune cross-talk during
fetal programming and its relevance on offspring’s addictive behavior susceptibility is still unclear. Here, we review the most relevant
scientific reports about the impact of hypercaloric nutritional fetal programming on central and peripheral inflammation and its
effects on addictive behavior of the offspring. |
| format | Article |
| id | eprints-17417 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| record_format | eprints |
| spelling | eprints-174172025-07-18T17:19:05Z http://eprints.uanl.mx/17417/ Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring Montalvo Martínez, Larisa Jajaira Maldonado Ruiz, Roger Alexis Cárdenas Tueme, Marcela Reséndez Pérez, Diana Camacho Morales, Alberto R Medicina en General Obesity or maternal overnutrition during pregnancy and lactation might have long-term consequences in offspring health. Fetal programming is characterized by adaptive responses to specific environmental conditions during early life stages. Programming alters gene expression through epigenetic modifications leading to a transgenerational effect of behavioral phenotypes in the offspring. Maternal intake of hypercaloric diets during fetal development programs aberrant behaviors resembling addiction in offspring. Programming by hypercaloric surplus sets a gene expression pattern modulating axonal pruning, synaptic signaling, and synaptic plasticity in selective regions of the reward system. Likewise, fetal programming can promote an inflammatory phenotype in peripheral and central sites through different cell types such as microglia and T and B cells, which contribute to disrupted energy sensing and behavioral pathways. Te molecular mechanism that regulates the central and peripheral immune cross-talk during fetal programming and its relevance on offspring’s addictive behavior susceptibility is still unclear. Here, we review the most relevant scientific reports about the impact of hypercaloric nutritional fetal programming on central and peripheral inflammation and its effects on addictive behavior of the offspring. 2018-06-20 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/17417/1/276.pdf http://eprints.uanl.mx/17417/1.haspreviewThumbnailVersion/276.pdf Montalvo Martínez, Larisa Jajaira y Maldonado Ruiz, Roger Alexis y Cárdenas Tueme, Marcela y Reséndez Pérez, Diana y Camacho Morales, Alberto (2018) Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring. BioMed Research International, 2018. pp. 1-11. ISSN 2314-6133 http://doi.org/10.1155/2018/8061389 doi:10.1155/2018/8061389 |
| spellingShingle | R Medicina en General Montalvo Martínez, Larisa Jajaira Maldonado Ruiz, Roger Alexis Cárdenas Tueme, Marcela Reséndez Pérez, Diana Camacho Morales, Alberto Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring |
| title_full | Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring |
| title_fullStr | Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring |
| title_full_unstemmed | Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring |
| title_short | Maternal overnutrition programs central inflammation and addiction-like behavior in Offspring |
| title_sort | maternal overnutrition programs central inflammation and addiction like behavior in offspring |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/17417/1/276.pdf |
| work_keys_str_mv | AT montalvomartinezlarisajajaira maternalovernutritionprogramscentralinflammationandaddictionlikebehaviorinoffspring AT maldonadoruizrogeralexis maternalovernutritionprogramscentralinflammationandaddictionlikebehaviorinoffspring AT cardenastuememarcela maternalovernutritionprogramscentralinflammationandaddictionlikebehaviorinoffspring AT resendezperezdiana maternalovernutritionprogramscentralinflammationandaddictionlikebehaviorinoffspring AT camachomoralesalberto maternalovernutritionprogramscentralinflammationandaddictionlikebehaviorinoffspring |