The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis
Abstract Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could l...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Acceso en línea: | http://eprints.uanl.mx/17145/1/252.pdf |
| _version_ | 1824414805549645824 |
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| author | Garay Mendoza, Domingo Villarreal Martínez, Laura Garza Bedolla, Alejandra Pérez Garza, Daniela Michelle Acosta Olivo, Carlos Alberto Vílchez Cavazos, José Félix Diaz Hutchinson, Cesar Gómez Almaguer, David Jaime Pérez, José Carlos Mancías Guerra, Consuelo |
| author_facet | Garay Mendoza, Domingo Villarreal Martínez, Laura Garza Bedolla, Alejandra Pérez Garza, Daniela Michelle Acosta Olivo, Carlos Alberto Vílchez Cavazos, José Félix Diaz Hutchinson, Cesar Gómez Almaguer, David Jaime Pérez, José Carlos Mancías Guerra, Consuelo |
| author_sort | Garay Mendoza, Domingo |
| collection | Repositorio Institucional |
| description | Abstract Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA. Method: This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G-CSF). SC were obtained by BM aspiration and administered in a single intra-articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT01485198. Results: A total of 61 patients were included. Socio-demographic characteristics, OA grades and initial scores were similar in both groups. The BM-SC group showed significant improvement in knee pain and quality of life during the 6-month follow-up. Conclusion: The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA. Key words: bone marrow, knee osteoarthritis, stem cells. |
| format | Article |
| id | eprints-17145 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-171452023-05-25T18:58:19Z http://eprints.uanl.mx/17145/ The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis Garay Mendoza, Domingo Villarreal Martínez, Laura Garza Bedolla, Alejandra Pérez Garza, Daniela Michelle Acosta Olivo, Carlos Alberto Vílchez Cavazos, José Félix Diaz Hutchinson, Cesar Gómez Almaguer, David Jaime Pérez, José Carlos Mancías Guerra, Consuelo Abstract Aim: Management of osteoarthritis (OA) is basically symptomatic. Recently, stem cells (SC) have been used in the search for an optimum treatment. We decided to conduct a controlled clinical trial to determine if a single intra-articular injection of in vivo stimulated bone marrow SC could lead to an improvement in pain management and quality of life in patients with knee OA. Method: This was a prospective, open-label, phase I/II clinical trial to assess the safety and efficacy of a single intra-articular injection of autologous stimulated bone marrow stem cells (BM-SC) in patients with knee OA. Individuals of both genders older than 30 years with confirmed diagnosis of OA who signed informed consent were included in two groups: SC group received in vivo BM stimulation with subcutaneous administration of granulocyte colony stimulating factor (G-CSF). SC were obtained by BM aspiration and administered in a single intra-articular injection. The control group received exclusively oral acetaminophen. Visual analogue scale and Western Ontario and McMaster Universities Osteoarthritis Index scores were performed at 1 week, 1 month and 6 months in both groups. This trial was registered in ClinialTrials.gov NCT01485198. Results: A total of 61 patients were included. Socio-demographic characteristics, OA grades and initial scores were similar in both groups. The BM-SC group showed significant improvement in knee pain and quality of life during the 6-month follow-up. Conclusion: The study demonstrates feasibility and supports efficacy of a completely ambulatory procedure in treatment of knee OA. Key words: bone marrow, knee osteoarthritis, stem cells. 2017 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/17145/1/252.pdf http://eprints.uanl.mx/17145/1.haspreviewThumbnailVersion/252.pdf Garay Mendoza, Domingo y Villarreal Martínez, Laura y Garza Bedolla, Alejandra y Pérez Garza, Daniela Michelle y Acosta Olivo, Carlos Alberto y Vílchez Cavazos, José Félix y Diaz Hutchinson, Cesar y Gómez Almaguer, David y Jaime Pérez, José Carlos y Mancías Guerra, Consuelo (2017) The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis. International Journal of Rheumatic Diseases, 21 (1). pp. 140-147. ISSN 17561841 http://doi.org/10.1111/1756-185X.13139 doi:10.1111/1756-185X.13139 |
| spellingShingle | Garay Mendoza, Domingo Villarreal Martínez, Laura Garza Bedolla, Alejandra Pérez Garza, Daniela Michelle Acosta Olivo, Carlos Alberto Vílchez Cavazos, José Félix Diaz Hutchinson, Cesar Gómez Almaguer, David Jaime Pérez, José Carlos Mancías Guerra, Consuelo The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| title_full | The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| title_fullStr | The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| title_full_unstemmed | The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| title_short | The effect of intra-articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| title_sort | effect of intra articular injection of autologous bone marrow stem cells on pain and knee function in patients with osteoarthritis |
| url | http://eprints.uanl.mx/17145/1/252.pdf |
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