Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico
Abstract Background and Objective: Marine environment represents countless and diverse resource for new drugs to combat major diseases. Extracts from four Laurencia species ( L. johnstonii, L. pacifica, L. gardneri and L. papillosa) from Baja California Sur, México were evaluated for their anti...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Asian Network for Scientific Information
2018
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/17125/1/241.pdf |
| _version_ | 1824414798986608640 |
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| author | García Davis, Sara Murillo Álvarez, Iván Muñoz Ochoa, Mauricio Carranza Torres, Edith Garza Padrón, Ruth Amelia Morales Rubio, María Eufemia Viveros Valdez, José Ezequiel |
| author_facet | García Davis, Sara Murillo Álvarez, Iván Muñoz Ochoa, Mauricio Carranza Torres, Edith Garza Padrón, Ruth Amelia Morales Rubio, María Eufemia Viveros Valdez, José Ezequiel |
| author_sort | García Davis, Sara |
| collection | Repositorio Institucional |
| description | Abstract
Background and Objective: Marine environment represents countless and diverse resource for new drugs to combat major diseases. Extracts from four Laurencia species ( L. johnstonii, L. pacifica, L. gardneri and L. papillosa) from Baja California Sur, México were evaluated for their antioxidant, antibacterial and cytotoxic activity. Methodology: The antioxidants activity of Laurencia sp. were evaluated using the radical scavenging activity in three in vitro radicals: 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and nitric oxide (NO). The antibacterial activity was evaluated by the broth microdilution method to determinate the Minimum Inhibitory Concentrations (MIC) against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Micrococcus luteus, Pseudomonas aerugi nosa and Klebsiella pneumoniae . The cytotoxicity was analyzed on HeLa (cervix adenocarcinoma) and Vero (kidney epithelial) cells, using the reduction of tetrazolium salt WST-1. Results: The seaweed of genus Laurencia demonstrated an overall low activity, with half maximal effective concentration (EC50) values >1.5 mg mLG1. Laurencia pacifica showed the best biocide effects with MIC of 6.25 µg mLG1 against Gram positive bacterial and cytotoxic potential with half inhibitory concentration (IC50) <30 µg mLG1 against Vero and HeLa cells. Conclusion: Some Laurencia species have a great antibacterial and cytotoxic activity which could be considered for future studies. |
| format | Article |
| id | eprints-17125 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| publisher | Asian Network for Scientific Information |
| record_format | eprints |
| spelling | eprints-171252024-03-05T18:27:38Z http://eprints.uanl.mx/17125/ Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico García Davis, Sara Murillo Álvarez, Iván Muñoz Ochoa, Mauricio Carranza Torres, Edith Garza Padrón, Ruth Amelia Morales Rubio, María Eufemia Viveros Valdez, José Ezequiel QD Química RM Terapéutica, Farmacología Abstract Background and Objective: Marine environment represents countless and diverse resource for new drugs to combat major diseases. Extracts from four Laurencia species ( L. johnstonii, L. pacifica, L. gardneri and L. papillosa) from Baja California Sur, México were evaluated for their antioxidant, antibacterial and cytotoxic activity. Methodology: The antioxidants activity of Laurencia sp. were evaluated using the radical scavenging activity in three in vitro radicals: 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and nitric oxide (NO). The antibacterial activity was evaluated by the broth microdilution method to determinate the Minimum Inhibitory Concentrations (MIC) against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Micrococcus luteus, Pseudomonas aerugi nosa and Klebsiella pneumoniae . The cytotoxicity was analyzed on HeLa (cervix adenocarcinoma) and Vero (kidney epithelial) cells, using the reduction of tetrazolium salt WST-1. Results: The seaweed of genus Laurencia demonstrated an overall low activity, with half maximal effective concentration (EC50) values >1.5 mg mLG1. Laurencia pacifica showed the best biocide effects with MIC of 6.25 µg mLG1 against Gram positive bacterial and cytotoxic potential with half inhibitory concentration (IC50) <30 µg mLG1 against Vero and HeLa cells. Conclusion: Some Laurencia species have a great antibacterial and cytotoxic activity which could be considered for future studies. Asian Network for Scientific Information 2018-03-15 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/17125/1/241.pdf http://eprints.uanl.mx/17125/1.haspreviewThumbnailVersion/241.pdf García Davis, Sara y Murillo Álvarez, Iván y Muñoz Ochoa, Mauricio y Carranza Torres, Edith y Garza Padrón, Ruth Amelia y Morales Rubio, María Eufemia y Viveros Valdez, José Ezequiel (2018) Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico. International Journal of Pharmacology, 14 (3). pp. 391-396. ISSN 18117775 http://doi.org/10.3923/ijp.2018.391.396 doi:10.3923/ijp.2018.391.396 |
| spellingShingle | QD Química RM Terapéutica, Farmacología García Davis, Sara Murillo Álvarez, Iván Muñoz Ochoa, Mauricio Carranza Torres, Edith Garza Padrón, Ruth Amelia Morales Rubio, María Eufemia Viveros Valdez, José Ezequiel Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico |
| title_full | Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico |
| title_fullStr | Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico |
| title_full_unstemmed | Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico |
| title_short | Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico |
| title_sort | bactericide antioxidant and cytotoxic activities from marine algae of genus laurencia collected in baja california sur mexico |
| topic | QD Química RM Terapéutica, Farmacología |
| url | http://eprints.uanl.mx/17125/1/241.pdf |
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