Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease
Background. Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease. Cerebral vasomotor reactivity could be an important biomarker for this pathology. Aims. The aim of this study was to investigate the alterations in cerebral vascular motorre activity in Alzheimer’...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/16623/1/223.pdf |
| _version_ | 1838550997122678784 |
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| author | Góngora Rivera, Juan Fernando Cordero Pérez, Adolfo González Aquines, Alejandro Anaya Escamilla, Antonio Villarreal Garza, Eduardo Espinosa Ortega, Meztli Salinas Carmona, Mario César Ortiz Jiménez, Xóchitl A. |
| author_facet | Góngora Rivera, Juan Fernando Cordero Pérez, Adolfo González Aquines, Alejandro Anaya Escamilla, Antonio Villarreal Garza, Eduardo Espinosa Ortega, Meztli Salinas Carmona, Mario César Ortiz Jiménez, Xóchitl A. |
| author_sort | Góngora Rivera, Juan Fernando |
| collection | Repositorio Institucional |
| description | Background. Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease. Cerebral vasomotor reactivity could be an important biomarker for this pathology. Aims. The aim of this study was to investigate the alterations in cerebral vascular motorre activity in Alzheimer’s disease subject sand to associate the sechanges with the ir cognitivescores. Methods. We recruited subjects with a diagnosis of Alzheimer’s disease and healthy controls. Demographic, clinical, imaging, and cognitive test were obtained. Then all participants performed a cerebral vascular motorre activity test with 7% CO2 and cerebral blood flow velocities (CBFV) were recorded with transcranial doppler ultrasound before and after the test. Results. Wer ecruited 45 subjects, 26 (21 female) Alzheimer’s disease participants and 19 (15 female) healthy controls. There were no differences in baseline cerebral blood flow velocities between the groups. After the cerebral vasomotor reactivity test, absolute mean difference in mean CBFV (ΔCBFV-m)was 8.70±4.14 versus4.81±6.96 (p<0.01), respectively. Calculated percentage of change (%CVMR) was lower in the ADgroup7.45±18.25versus23.29±17.48, and there was a positive but weak correlation with mini-mental scores. |
| format | Article |
| id | eprints-16623 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| record_format | eprints |
| spelling | eprints-166232025-07-16T15:59:01Z http://eprints.uanl.mx/16623/ Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease Góngora Rivera, Juan Fernando Cordero Pérez, Adolfo González Aquines, Alejandro Anaya Escamilla, Antonio Villarreal Garza, Eduardo Espinosa Ortega, Meztli Salinas Carmona, Mario César Ortiz Jiménez, Xóchitl A. RC Medicina Interna, Psiquiatría, Neurología Background. Recent studies have shown that cerebral vascularity may be impaired in Alzheimer’s disease. Cerebral vasomotor reactivity could be an important biomarker for this pathology. Aims. The aim of this study was to investigate the alterations in cerebral vascular motorre activity in Alzheimer’s disease subject sand to associate the sechanges with the ir cognitivescores. Methods. We recruited subjects with a diagnosis of Alzheimer’s disease and healthy controls. Demographic, clinical, imaging, and cognitive test were obtained. Then all participants performed a cerebral vascular motorre activity test with 7% CO2 and cerebral blood flow velocities (CBFV) were recorded with transcranial doppler ultrasound before and after the test. Results. Wer ecruited 45 subjects, 26 (21 female) Alzheimer’s disease participants and 19 (15 female) healthy controls. There were no differences in baseline cerebral blood flow velocities between the groups. After the cerebral vasomotor reactivity test, absolute mean difference in mean CBFV (ΔCBFV-m)was 8.70±4.14 versus4.81±6.96 (p<0.01), respectively. Calculated percentage of change (%CVMR) was lower in the ADgroup7.45±18.25versus23.29±17.48, and there was a positive but weak correlation with mini-mental scores. 2018-09-09 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/16623/1/223.pdf http://eprints.uanl.mx/16623/1.haspreviewThumbnailVersion/223.pdf Góngora Rivera, Juan Fernando y Cordero Pérez, Adolfo y González Aquines, Alejandro y Anaya Escamilla, Antonio y Villarreal Garza, Eduardo y Espinosa Ortega, Meztli y Salinas Carmona, Mario César y Ortiz Jiménez, Xóchitl A. (2018) Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease. International Journal of Alzheimer's Disease, 2018. pp. 1-5. ISSN 2090-8024 http://doi.org/10.1155/2018/9328293 doi:10.1155/2018/9328293 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Góngora Rivera, Juan Fernando Cordero Pérez, Adolfo González Aquines, Alejandro Anaya Escamilla, Antonio Villarreal Garza, Eduardo Espinosa Ortega, Meztli Salinas Carmona, Mario César Ortiz Jiménez, Xóchitl A. Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease |
| title_full | Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease |
| title_fullStr | Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease |
| title_full_unstemmed | Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease |
| title_short | Impaired Cerebral Vasomotor Reactivity in Alzheimer’s Disease |
| title_sort | impaired cerebral vasomotor reactivity in alzheimer s disease |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/16623/1/223.pdf |
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