Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review)
Abstract. Biotransformation is an enzyme-catalyzed process in which the body converts endogenous compounds, xenobiotics and toxic substances into harmless or easily excreted metabolites. The biotransformation reactions are classified as phase I and II reactions. Uridine 5'-diphospho (UDP)-glucu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2018
|
| Online Access: | http://eprints.uanl.mx/16193/1/110.pdf |
| _version_ | 1824414529996455936 |
|---|---|
| author | Sánchez Domínguez, Celia Nohemí Gallardo Blanco, Hugo Leonid Salinas Santander, Mauricio Andrés Ortiz López, Rocío |
| author_facet | Sánchez Domínguez, Celia Nohemí Gallardo Blanco, Hugo Leonid Salinas Santander, Mauricio Andrés Ortiz López, Rocío |
| author_sort | Sánchez Domínguez, Celia Nohemí |
| collection | Repositorio Institucional |
| description | Abstract. Biotransformation is an enzyme-catalyzed process in which the body converts endogenous compounds, xenobiotics and toxic substances into harmless or easily excreted metabolites. The biotransformation reactions are classified as phase I and II reactions. Uridine 5'-diphospho (UDP)-glucuronosyltransferases (UGTs) are a superfamily of phase II enzymes which have roles in the conjugation of xenobiotics or endogenous compounds, including drugs and bilirubin, with glucuronic acid to make them easier to excrete. The method the human body uses to achieve glucuronidation may be affected by a large interindividual variation due to changes in the sequences of the genes encoding these enzymes. In the last five years, the study of the genetic variants of the UGTs at a molecular level has become important due to its association with several diseases and the ability to predict adverse events due to drug metabolism. In the present review, the structure and the prominent genetic variants of the UGT1A subfamily and their metabolic and clinical implications are described. |
| format | Article |
| id | eprints-16193 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| record_format | eprints |
| spelling | eprints-161932020-06-09T20:58:38Z http://eprints.uanl.mx/16193/ Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) Sánchez Domínguez, Celia Nohemí Gallardo Blanco, Hugo Leonid Salinas Santander, Mauricio Andrés Ortiz López, Rocío Abstract. Biotransformation is an enzyme-catalyzed process in which the body converts endogenous compounds, xenobiotics and toxic substances into harmless or easily excreted metabolites. The biotransformation reactions are classified as phase I and II reactions. Uridine 5'-diphospho (UDP)-glucuronosyltransferases (UGTs) are a superfamily of phase II enzymes which have roles in the conjugation of xenobiotics or endogenous compounds, including drugs and bilirubin, with glucuronic acid to make them easier to excrete. The method the human body uses to achieve glucuronidation may be affected by a large interindividual variation due to changes in the sequences of the genes encoding these enzymes. In the last five years, the study of the genetic variants of the UGTs at a molecular level has become important due to its association with several diseases and the ability to predict adverse events due to drug metabolism. In the present review, the structure and the prominent genetic variants of the UGT1A subfamily and their metabolic and clinical implications are described. 2018-11-17 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/16193/1/110.pdf http://eprints.uanl.mx/16193/1.haspreviewThumbnailVersion/110.pdf Sánchez Domínguez, Celia Nohemí y Gallardo Blanco, Hugo Leonid y Salinas Santander, Mauricio Andrés y Ortiz López, Rocío (2018) Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review). Experimental and Therapeutic Medicine. pp. 3-11. ISSN 1792-0981 http://doi.org/10.3892/etm.2018.6184 doi:10.3892/etm.2018.6184 |
| spellingShingle | Sánchez Domínguez, Celia Nohemí Gallardo Blanco, Hugo Leonid Salinas Santander, Mauricio Andrés Ortiz López, Rocío Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) |
| title_full | Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) |
| title_fullStr | Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) |
| title_full_unstemmed | Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) |
| title_short | Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review) |
| title_sort | uridine 5 diphospho glucronosyltrasferase its role in pharmacogenomics and human disease review |
| url | http://eprints.uanl.mx/16193/1/110.pdf |
| work_keys_str_mv | AT sanchezdominguezcelianohemi uridine5diphosphoglucronosyltrasferaseitsroleinpharmacogenomicsandhumandiseasereview AT gallardoblancohugoleonid uridine5diphosphoglucronosyltrasferaseitsroleinpharmacogenomicsandhumandiseasereview AT salinassantandermauricioandres uridine5diphosphoglucronosyltrasferaseitsroleinpharmacogenomicsandhumandiseasereview AT ortizlopezrocio uridine5diphosphoglucronosyltrasferaseitsroleinpharmacogenomicsandhumandiseasereview |