Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq
Abstract Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the a...
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| Format: | Article |
| Language: | English |
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2017
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| Online Access: | http://eprints.uanl.mx/16088/1/66.pdf |
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| author | Martínez Jacobo, Lizeth Alejandra Ancer Arellano, Claudia I. Ortiz López, Rocío Salinas Santander, Mauricio Andrés Villarreal Villarreal, César Daniel Ancer Rodríguez, Jesús Camacho Zamora, Bianka Dianey Zomosa Signoret, Viviana Chantal Medina de la Garza, Carlos Eduardo Ocampo Candiani, Jorge Rojas Martínez, Augusto |
| author_facet | Martínez Jacobo, Lizeth Alejandra Ancer Arellano, Claudia I. Ortiz López, Rocío Salinas Santander, Mauricio Andrés Villarreal Villarreal, César Daniel Ancer Rodríguez, Jesús Camacho Zamora, Bianka Dianey Zomosa Signoret, Viviana Chantal Medina de la Garza, Carlos Eduardo Ocampo Candiani, Jorge Rojas Martínez, Augusto |
| author_sort | Martínez Jacobo, Lizeth Alejandra |
| collection | Repositorio Institucional |
| description | Abstract Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder. |
| format | Article |
| id | eprints-16088 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-160882025-07-23T16:53:50Z http://eprints.uanl.mx/16088/ Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq Martínez Jacobo, Lizeth Alejandra Ancer Arellano, Claudia I. Ortiz López, Rocío Salinas Santander, Mauricio Andrés Villarreal Villarreal, César Daniel Ancer Rodríguez, Jesús Camacho Zamora, Bianka Dianey Zomosa Signoret, Viviana Chantal Medina de la Garza, Carlos Eduardo Ocampo Candiani, Jorge Rojas Martínez, Augusto RC Medicina Interna, Psiquiatría, Neurología RL Dermatología RM Terapéutica, Farmacología Abstract Androgenetic alopecia (AGA) or male pattern baldness is the most common form of hair loss in humans. Despite being a very frequent dermatological entity, molecular pathophysiology remains unclear. Several authors relate the presentation of AGA with a premature apoptotic process during the anagen phase and with an inflammatory microenvironment in the hair follicle. We evaluated a panel of 30 genes associated with inflammation and apoptosis in 5 AGA patients by targeted RNA-Seq. WNT7A gene was highly expressed in patients in stages 3V to 5 on the Hamilton-Norwood scale compared to patients with 5A stage. CASP7 and TNF genes were overexpressed in stages 3V and 4 compared to stages 5 and 5A. Overexpression of these genes detected only at early stages of AGA proves the role of WNT pathway, apoptosis, and inflammation in the development of this disorder. 2017-12-07 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/16088/1/66.pdf http://eprints.uanl.mx/16088/1.haspreviewThumbnailVersion/66.pdf Martínez Jacobo, Lizeth Alejandra y Ancer Arellano, Claudia I. y Ortiz López, Rocío y Salinas Santander, Mauricio Andrés y Villarreal Villarreal, César Daniel y Ancer Rodríguez, Jesús y Camacho Zamora, Bianka Dianey y Zomosa Signoret, Viviana Chantal y Medina de la Garza, Carlos Eduardo y Ocampo Candiani, Jorge y Rojas Martínez, Augusto (2017) Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq. Skin Appendage Disorders, 4 (4). pp. 268-273. ISSN 2296-9195 http://doi.org/10.1159/000484530 doi:10.1159/000484530 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología RL Dermatología RM Terapéutica, Farmacología Martínez Jacobo, Lizeth Alejandra Ancer Arellano, Claudia I. Ortiz López, Rocío Salinas Santander, Mauricio Andrés Villarreal Villarreal, César Daniel Ancer Rodríguez, Jesús Camacho Zamora, Bianka Dianey Zomosa Signoret, Viviana Chantal Medina de la Garza, Carlos Eduardo Ocampo Candiani, Jorge Rojas Martínez, Augusto Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq |
| title_full | Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq |
| title_fullStr | Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq |
| title_full_unstemmed | Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq |
| title_short | Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq |
| title_sort | evaluation of the expression of genes associated with inflammation and apoptosis in androgenetic alopecia by targeted rna seq |
| topic | RC Medicina Interna, Psiquiatría, Neurología RL Dermatología RM Terapéutica, Farmacología |
| url | http://eprints.uanl.mx/16088/1/66.pdf |
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