Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii
Focusedonourinteresttodevelopnovelantiparasisticagents,thepresentstudywasaimed to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja California Sur, Mexico, against an Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us to identify the...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Molecular Diversity Preservation International
2018
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/15976/1/48.pdf |
| _version_ | 1824414450996740096 |
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| author | García Davis, Sara Sifaoui, Ines Reyes Batlle, María Viveros Valdez, José Ezequiel Piñero, José Lorenzo Morales, Jacob Fernández, José J. Díaz Marrero, Ana R. |
| author_facet | García Davis, Sara Sifaoui, Ines Reyes Batlle, María Viveros Valdez, José Ezequiel Piñero, José Lorenzo Morales, Jacob Fernández, José J. Díaz Marrero, Ana R. |
| author_sort | García Davis, Sara |
| collection | Repositorio Institucional |
| description | Focusedonourinteresttodevelopnovelantiparasisticagents,thepresentstudywasaimed to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja California Sur, Mexico, against an Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us to identify the amoebicidal diastereoisomers α-bromocuparane (4) and α-isobromocuparane (5). Furthermore, bromination of the inactive laurinterol (1) and isolaurinterol (2) yielded four halogenated derivatives, (6)–(9), which improved the activity of the natural sesquiterpenes. Among them, the most active compound was 3α-bromojohnstane (7), a sesquiterpene derivative which possesses a novel carbon skeleton johnstane. |
| format | Article |
| id | eprints-15976 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| publisher | Molecular Diversity Preservation International |
| record_format | eprints |
| spelling | eprints-159762024-12-09T17:44:27Z http://eprints.uanl.mx/15976/ Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii García Davis, Sara Sifaoui, Ines Reyes Batlle, María Viveros Valdez, José Ezequiel Piñero, José Lorenzo Morales, Jacob Fernández, José J. Díaz Marrero, Ana R. RS Farmacia y Materia Médica Focusedonourinteresttodevelopnovelantiparasisticagents,thepresentstudywasaimed to evaluate the biological activity of an extract of Laurencia johnstonii collected in Baja California Sur, Mexico, against an Acantamoeba castellanii Neff strain. Bioassay-guided fractionation allowed us to identify the amoebicidal diastereoisomers α-bromocuparane (4) and α-isobromocuparane (5). Furthermore, bromination of the inactive laurinterol (1) and isolaurinterol (2) yielded four halogenated derivatives, (6)–(9), which improved the activity of the natural sesquiterpenes. Among them, the most active compound was 3α-bromojohnstane (7), a sesquiterpene derivative which possesses a novel carbon skeleton johnstane. Molecular Diversity Preservation International 2018-11-11 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15976/1/48.pdf http://eprints.uanl.mx/15976/1.haspreviewThumbnailVersion/48.pdf García Davis, Sara y Sifaoui, Ines y Reyes Batlle, María y Viveros Valdez, José Ezequiel y Piñero, José y Lorenzo Morales, Jacob y Fernández, José J. y Díaz Marrero, Ana R. (2018) Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii. Marine drugs, 16 (11). pp. 1-12. ISSN 1660-3397 http://doi.org/10.3390/md16110443 doi:10.3390/md16110443 |
| spellingShingle | RS Farmacia y Materia Médica García Davis, Sara Sifaoui, Ines Reyes Batlle, María Viveros Valdez, José Ezequiel Piñero, José Lorenzo Morales, Jacob Fernández, José J. Díaz Marrero, Ana R. Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii |
| title_full | Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii |
| title_fullStr | Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii |
| title_full_unstemmed | Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii |
| title_short | Anti-Acanthamoeba Activity of Brominated Sesquiterpenes from Laurencia johnstonii |
| title_sort | anti acanthamoeba activity of brominated sesquiterpenes from laurencia johnstonii |
| topic | RS Farmacia y Materia Médica |
| url | http://eprints.uanl.mx/15976/1/48.pdf |
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