Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico
Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and efective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larva...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/15966/1/39.pdf |
| _version_ | 1824414447672754176 |
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| author | Saavedra Rodríguez, Karla Lizet Maloof, Farah Vera Campbell, Corey L. García Rejón, Julián Everardo Lenhart, Audrey Penilla, Patricia Rodriguez, Americo Sandoval, Arturo Acero Flores, Adriana E. Ponce García, Gustavo Lozano, Saul Black, William C. |
| author_facet | Saavedra Rodríguez, Karla Lizet Maloof, Farah Vera Campbell, Corey L. García Rejón, Julián Everardo Lenhart, Audrey Penilla, Patricia Rodriguez, Americo Sandoval, Arturo Acero Flores, Adriana E. Ponce García, Gustavo Lozano, Saul Black, William C. |
| author_sort | Saavedra Rodríguez, Karla Lizet |
| collection | Repositorio Institucional |
| description | Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and efective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid spacesprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identifed in Brazil and its efect on vgsc was confrmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the frst heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specifc vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management. |
| format | Article |
| id | eprints-15966 |
| institution | UANL |
| language | English |
| publishDate | 2018 |
| record_format | eprints |
| spelling | eprints-159662021-08-24T20:32:29Z http://eprints.uanl.mx/15966/ Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico Saavedra Rodríguez, Karla Lizet Maloof, Farah Vera Campbell, Corey L. García Rejón, Julián Everardo Lenhart, Audrey Penilla, Patricia Rodriguez, Americo Sandoval, Arturo Acero Flores, Adriana E. Ponce García, Gustavo Lozano, Saul Black, William C. QR Microbiología Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and efective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid spacesprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identifed in Brazil and its efect on vgsc was confrmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the frst heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specifc vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management. 2018 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15966/1/39.pdf http://eprints.uanl.mx/15966/1.haspreviewThumbnailVersion/39.pdf Saavedra Rodríguez, Karla Lizet y Maloof, Farah Vera y Campbell, Corey L. y García Rejón, Julián Everardo y Lenhart, Audrey y Penilla, Patricia y Rodriguez, Americo y Sandoval, Arturo Acero y Flores, Adriana E. y Ponce García, Gustavo y Lozano, Saul y Black, William C. (2018) Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico. Scientific Reports, 8 (1). pp. 1-9. ISSN 2045-2322 http://doi.org/10.1038/s41598-018-25222-0 doi:10.1038/s41598-018-25222-0 |
| spellingShingle | QR Microbiología Saavedra Rodríguez, Karla Lizet Maloof, Farah Vera Campbell, Corey L. García Rejón, Julián Everardo Lenhart, Audrey Penilla, Patricia Rodriguez, Americo Sandoval, Arturo Acero Flores, Adriana E. Ponce García, Gustavo Lozano, Saul Black, William C. Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico |
| title_full | Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico |
| title_fullStr | Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico |
| title_full_unstemmed | Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico |
| title_short | Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico |
| title_sort | parallel evolution of vgsc mutations at domains is6 iis6 and iiis6 in pyrethroid resistant aedes aegypti from mexico |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/15966/1/39.pdf |
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