Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge
Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in so...
| Autores principales: | , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2014
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| Acceso en línea: | http://eprints.uanl.mx/15235/1/337.pdf |
| _version_ | 1824414294622601216 |
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| author | Ocampo Garza, Jorge Herz Ruelas, Maira Elizabeth González Lopez, Elias Eugenio Mendoza Oviedo, Eric Eduardo Garza Chapa, Juana Irma Ocampo Garza, Sonia Sofía Vázquez Herrera, Norma Elizabeth Miranda Maldonado, Ivett C. Ocampo Candiani, Jorge |
| author_facet | Ocampo Garza, Jorge Herz Ruelas, Maira Elizabeth González Lopez, Elias Eugenio Mendoza Oviedo, Eric Eduardo Garza Chapa, Juana Irma Ocampo Garza, Sonia Sofía Vázquez Herrera, Norma Elizabeth Miranda Maldonado, Ivett C. Ocampo Candiani, Jorge |
| author_sort | Ocampo Garza, Jorge |
| collection | Repositorio Institucional |
| description | Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules,
papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of
AITL was confirmed by an axillary lymph node biopsy, which was also positive for EpsteinBarr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles. |
| format | Article |
| id | eprints-15235 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| record_format | eprints |
| spelling | eprints-152352022-04-07T22:00:09Z http://eprints.uanl.mx/15235/ Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge Ocampo Garza, Jorge Herz Ruelas, Maira Elizabeth González Lopez, Elias Eugenio Mendoza Oviedo, Eric Eduardo Garza Chapa, Juana Irma Ocampo Garza, Sonia Sofía Vázquez Herrera, Norma Elizabeth Miranda Maldonado, Ivett C. Ocampo Candiani, Jorge RL Dermatología Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for EpsteinBarr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles. 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15235/1/337.pdf http://eprints.uanl.mx/15235/1.haspreviewThumbnailVersion/337.pdf Ocampo Garza, Jorge y Herz Ruelas, Maira Elizabeth y González Lopez, Elias Eugenio y Mendoza Oviedo, Eric Eduardo y Garza Chapa, Juana Irma y Ocampo Garza, Sonia Sofía y Vázquez Herrera, Norma Elizabeth y Miranda Maldonado, Ivett C. y Ocampo Candiani, Jorge (2014) Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge. Case reports in dermatology, 6 (3). pp. 291-295. ISSN 1662-6567 http://doi.org/10.1159/000370302 doi:10.1159/000370302 |
| spellingShingle | RL Dermatología Ocampo Garza, Jorge Herz Ruelas, Maira Elizabeth González Lopez, Elias Eugenio Mendoza Oviedo, Eric Eduardo Garza Chapa, Juana Irma Ocampo Garza, Sonia Sofía Vázquez Herrera, Norma Elizabeth Miranda Maldonado, Ivett C. Ocampo Candiani, Jorge Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge |
| title_full | Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge |
| title_fullStr | Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge |
| title_full_unstemmed | Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge |
| title_short | Angioimmunoblastic T-Cell lymphoma: a diagnostic challenge |
| title_sort | angioimmunoblastic t cell lymphoma a diagnostic challenge |
| topic | RL Dermatología |
| url | http://eprints.uanl.mx/15235/1/337.pdf |
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